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Caenorhabditis Elegans

All articles tagged with #caenorhabditis elegans

Hidden Plant Compound May Extend Lifespan, Study Finds in Worms
science1 month ago

Hidden Plant Compound May Extend Lifespan, Study Finds in Worms

A colorless carotenoid called phytoene, found in common fruits and vegetables, extended lifespans by 10–18.6% and reduced amyloid-β toxicity in C. elegans, suggesting potential benefits for aging and brain health. The effects were observed with purified phytoene and microalgae extracts, and included improved resistance to oxidative stress without affecting growth, but human relevance remains unproven; microalgae are highlighted as a sustainable phytoene source and potential future applications in skin health and neurodegeneration.

via SciTechDaily|
#aging#alzheimers-disease#caenorhabditis-elegans
Neuron-type aging clocks map vulnerability and unveil neuroprotective drug candidates
science3 months ago

Neuron-type aging clocks map vulnerability and unveil neuroprotective drug candidates

Aging clocks applied to single neuron types in C. elegans reveal neuron-type–specific biological ages, with environmentally exposed ciliated amphid neurons aging fastest and degenerating earlier. Reducing translation slows degeneration in fast-aging neurons, and neuronal aging patterns correlate with human brain aging while anticorrelating with known geroprotective interventions. An in silico CMAP screen identifies potential neuroprotective compounds, notably syringic acid and vanoxerine, while some agents (e.g., WAY-100635, Bay K8644) can be neurotoxic. The study suggests neuron-type aging trajectories can guide protective interventions and risk-factor identification for neurodegeneration across species.

via Nature|
#aging-clocks#caenorhabditis-elegans#neurodegeneration
AI Revolutionizes Neuron Tracking in Moving Animals with Enhanced Precision
neuroscience2 years ago

AI Revolutionizes Neuron Tracking in Moving Animals with Enhanced Precision

Researchers have developed an AI-based method using a convolutional neural network (CNN) to track neurons in moving and deforming animals, such as the roundworm Caenorhabditis elegans. This innovative technique, which incorporates targeted augmentation, reduces the need for manual image annotation and significantly increases analysis efficiency. The CNN method has revealed complex interneuron behaviors and responses to stimuli, deepening insights into neuronal activities. This breakthrough has the potential to accelerate research in brain imaging and enhance our understanding of neural circuits and behaviors.

via Neuroscience News|
#ai#caenorhabditis-elegans#convolutional-neural-network
Unveiling the First Wireless Nerve Signal Map in Worms
neuroscience2 years ago

Unveiling the First Wireless Nerve Signal Map in Worms

Two recent studies have revealed the existence of a 'wireless' nerve network in the worm Caenorhabditis elegans, challenging the traditional understanding that nerve cells communicate only through synapses. The studies mapped out the entire network of neuropeptide communication in C. elegans, showing that neuropeptides can pass messages between cells over longer distances. This wireless communication, which involves the release and interception of neuropeptides by different neurons, was found to directly activate neurons and contribute significantly to the propagation of signals in the worm's nervous system. The findings suggest that neuropeptide communication is equally important and complex as synaptic signaling, and understanding this network could have implications for the development of drugs and our understanding of neural dynamics in other organisms, including humans.

via Nature.com|
#caenorhabditis-elegans#nervous-system#neurons