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Fecal Microbiota Transplant

All articles tagged with #fecal microbiota transplant

health15 days ago•9 min saved

Young patient’s decade-long C. diff battle highlights shifting infection risks and the value of community support

Minnie Hatch, a 31-year-old from Ogden, Utah, spent a decade battling recurrent Clostridioides difficile (C. diff) infections before discovering she has a primary immunodeficiency disorder. Her journey illustrates how C. diff is increasingly affecting younger, community-dwelling patients rather than just the elderly in hospitals. After multiple recurrences and three fecal microbiota transplants (FMTs), Hatch found stability through intravenous immunoglobulin (IVIG) therapy. Her experience underscores the importance of patient advocacy and community resources like the Peggy Lillis Foundation in navigating complex, chronic infections.

via CIDRAP|

#antibiotics #c-diff #fecal-microbiota-transplant

health1 month ago•4 min saved

Gut Bacteria Transplants Offer Sleep Gains in Small Insomnia Trial

In a small study, adults with chronic insomnia received fecal microbiota transplant capsules after a two‑day course of antibiotics. Sleep efficiency rose from about 79% to 93% after one month, and time awake at night dropped from 79 to 17 minutes; self-reported sleep improvements persisted for months. The placebo group saw little change, but antibiotics and the small sample size mean it’s unclear how much of the effect is due to the transplants, underscoring the need for larger trials.

via New York Post|

#fecal-microbiota-transplant #gut-health #health

science1 month ago•7 min saved

Gut bacteria link to Parkinson's, sparking microbiome-based therapy hopes

New studies connect Parkinson's progression to gut microbiome disruptions, notably fewer bacteria that produce B vitamins riboflavin (B2) and biotin (B7), which may weaken the intestinal barrier and fuel brain inflammation via alpha-synuclein. Small fecal microbiota transplant trials in Belgium and China show motor and gastrointestinal improvements, with a larger Chinese trial confirming donor transplants can yield meaningful benefits. The findings point to riboflavin/biotin supplementation and gut microbiome modulation as potential therapies, but results require further validation in bigger trials.

via ScienceAlert|

#biotin #fecal-microbiota-transplant #gut-microbiome

health1 month ago•7 min saved

Gut microbiome transplant offers early hope for peanut allergy treatment

In a phase 1, open-label trial at Boston Children’s Hospital, 15 adults with peanut allergies received fecal microbiota transplants to reset the gut microbiome. Ten participants received FMT capsules and five later got a transplant after antibiotics; about 40% achieved meaningful, durable increases in peanut tolerance (up to 300–600 mg, with one participant tolerating 1,043 mg) lasting at least four months. Side effects were minor and no major adverse events occurred. While promising, larger randomized trials are needed and FMT is not yet ready for clinical use; mouse studies suggested two Bacteroides species may drive the protective effect.

via ScienceAlert|

#clinical-trial #fecal-microbiota-transplant #gut-microbiome

health3 months ago•5 min saved

Your Co-habitants May Tune Your Gut Microbiome More Than Your Diet

A study shows people who live together share about 26% of their oral microbes, with romantic partners sharing 44%, implying that household cohabitation shapes both oral and gut microbiomes beyond diet. The oral–gut microbiome axis means microbes can transfer via saliva and shared environments, potentially influencing health and the effectiveness of treatments like fecal microbiota transplantation, and microbial exchange can extend to broader communities albeit more weakly.

via New York Post|

#fecal-microbiota-transplant #gut-health #health

science4 months ago•16 min saved

Healthy Guts, Stronger Cancer Immunotherapy

New research shows gut bacteria profoundly influence cancer treatment outcomes, especially immunotherapies. Scientists are reducing broad-spectrum antibiotic use, optimizing diet, and testing probiotics and fecal microbiota transplants to preserve beneficial gut microbes, with early trials suggesting improved responses and fewer complications—though the microbiome’s role remains complex and more evidence is needed.

via CP24|

#antibiotics #cancer #fecal-microbiota-transplant

health4 months ago•4 min saved

Nova Scotia Man’s Gut Produces Alcohol, Unveiling a Rare Auto-Brewery Syndrome

In Nova Scotia, Eric Poulin has auto-brewery syndrome, a rare condition where gut microbes ferment alcohol, causing intoxication without drinking; diagnosis took nearly 10 years, with limited effective treatments and ongoing exploration of a fecal microbiota transplant, while his wife advocates via a symptom-tracking app and he has been out of work since 2023.

via CBC|

#auto-brewery-syndrome #fecal-microbiota-transplant #gut-microbiome

science6 months ago•6 min saved

Young Microbes Reboot Aging Gut by Reviving Stem Cells

Transferring gut microbes from young to aged mice rejuvenates the gut by reactivating intestinal stem cells, restoring crypt-villi structure and barrier function, and reducing inflammatory gene expression. The effects are mediated by microbial metabolites such as indole-3-aldehyde and butyrate, with Akkermansia muciniphila enrichment linked to the benefits.

via Indian Defence Review|

#aging #fecal-microbiota-transplant #gut-barrier

science6 months ago•5 min saved

Gut microbes may slow age-related cognitive decline, new review suggests

A review of 15 trials with about 4,275 adults suggests that modulating the gut microbiome through diet, probiotics/prebiotics, or fecal microbiota transplantation can modestly improve memory, executive function, and overall cognition in older adults—especially those with early cognitive impairment—though effects are limited in advanced Alzheimer's. Dietary approaches like the Mediterranean diet show promise, FMT shows rapid microbial shifts with some cognitive gains in small Alzheimer’s cases, but long-term safety and efficacy require more randomized trials.

via ScienceAlert|

#cognitive-decline #fecal-microbiota-transplant #gut-brain-axis

science8 months ago•6 min saved

Gut Microbes Brew Alcohol: Donor Stool Transplants Offer Hope for Auto-Brewery Syndrome

Researchers detail auto-brewery syndrome (ABS), a rare condition where gut microbes convert carbohydrates into ethanol, causing involuntary intoxication. A Nature Microbiology study identifies overabundant bacteria (notably E. coli and Klebsiella) and fermentation pathways that drive ethanol production during flares, while fungal overgrowth is less central than once thought. The work also documents a successful treatment: a donor stool–derived capsule fecal microbiota transplant that produced long-lasting remission in at least one patient, implying a diagnostic framework and the potential for microbiome-directed therapies to manage ABS.

via Indian Defence Review|

#auto-brewery-syndrome #ethanol-production #fecal-microbiota-transplant

health1 year ago•7 min saved

Reevaluating Fecal Transplants: Benefits, Risks, and Future Directions

New research warns that fecal microbiota transplants (FMT) can cause long-lasting mismatches in gut regions, leading to metabolic and behavioral changes, and proposes omni-microbial transplants to better match microbes with their native gut environments.

via Neuroscience News|

#fecal-microbiota-transplant #gut-microbiota #health

health2 years ago•6 min saved

"FDA Issues Warning on 'Gut-Boosting' Pills Containing Donor Fecal Matter"

The FDA has issued a warning against the use of at-home fecal microbiota transplant (FMT) products, such as those offered by Human Microbes, due to significant safety concerns and lack of regulation. While FMT has shown promise in treating certain infections, the use of unregulated products containing other people's fecal matter poses serious risks, including potentially deadly infections. Experts emphasize the importance of proper screening and regulation in FMT products to ensure safety and efficacy.

via Daily Mail|

#fda #fecal-microbiota-transplant #gut-health

health2 years ago•3 min saved

"Fecal Microbiota Transplant Shows Promise in Alleviating Parkinson's Symptoms"

A small clinical trial found that fecal microbiota transplant, a procedure that replaces a person’s gut bacteria with bacteria from a healthy donor, may help ease motor symptoms of Parkinson’s disease. The study showed that patients with mild to moderate Parkinson’s who underwent the transplant experienced improved motor symptoms and less severe constipation. While the findings are promising, larger studies are needed to confirm the results and explore the potential of this therapeutic approach in patients at various disease stages.

via Parkinson's News Today|

#clinical-trial #fecal-microbiota-transplant #gut-bacteria

health3 years ago•3 min saved

FDA approves groundbreaking fecal transplant pill for gut health.

The FDA has approved the first pill made from donated human feces, called Vowst, as a preventive treatment for recurrent infections with the bacterium Clostridioides difficile. The pill contains live bacteria and is taken orally, unlike the previously approved enema-based treatment. Antibiotics can disrupt the balance of bacteria in the gut, leading to C. diff infections. Fecal microbiota products offer a new way to prevent recurrent C. diff by replenishing the gut microbiome. The Vowst treatment regimen involves taking four capsules once a day for three days in a row, starting two to four days after finishing a course of antibiotics for C. diff.

via Livescience.com|

#antibiotics #clostridioides-difficile #fda