Tag

Fibromyalgia

All articles tagged with #fibromyalgia

health27 days ago•84 min saved

Brain-focused genes emerge as key drivers of fibromyalgia in a 2.5 million-person study

A multi-ancestry GWAS meta-analysis of 2.56 million individuals (54,629 cases; 2,509,126 controls) identified 26 fibromyalgia risk loci, led by a coding HTT variant; neural genes such as DCC, DRD2/NCAM1, MDGA2 and CELF4 highlight brain pathways as central to fibromyalgia. Heritability is enriched in brain tissues and neurons, with dentate gyrus neurons showing the strongest signal, supporting a CNS basis and possible gut–brain interactions via enteric neurons. Genetic correlations show widespread pleiotropy with chronic pain, psychiatric and metabolic traits, notably pain syndromes and PTSD. The genetic architecture is nearly identical in males and females, despite prevalence differences. Polygenic risk scores have modest predictive value (highest AUC ~0.59 in Europeans) and can stratify risk. Therapeutic implications include HTT/GPR52 and CELF4 targets, arguing against a primary autoimmune etiology. Limitations include predominantly European ancestry and ICD-based phenotyping; replication in diverse groups is needed. Overall, findings map fibromyalgia to central nervous system biology and provide molecular entry points for future research.

via Nature|

#brain #fibromyalgia #genetics

health4 months ago•9 min saved

TENS Adds Pain and Fatigue Relief to Fibromyalgia Therapy in Real-World Study

A real-world trial across 28 clinics found that adding transcutaneous electrical nerve stimulation (TENS) to standard physical therapy significantly reduced movement-evoked pain and fatigue in fibromyalgia patients, with a dose-dependent effect lasting at least six months. About 80% of participants found TENS helpful and 70% felt better overall, and the benefits did not fade over time, making TENS a safe, inexpensive adjunct to PT and medications rather than a standalone cure.

via Neuroscience News|

#fatigue #fibromyalgia #health

health8 months ago•4 min saved

Federal Court Rules Social Security Must Address Fibromyalgia Complaints

A U.S. circuit court ruled that in cases like fibromyalgia, where no objective medical tests exist, subjective patient testimony must be given significant weight in disability benefit decisions, reversing a previous denial for a woman suffering from the condition and emphasizing the importance of recognizing such illnesses in the disability process.

via Maryland Matters|

#court-ruling #disability-benefits #fibromyalgia

health9 months ago•5 min saved

Scientists May Have Unraveled the Mystery of Fibromyalgia Pain

A large genetic study has identified 26 genetic regions linked to fibromyalgia, revealing that the condition primarily originates in the brain's neural circuits that control pain sensitivity, rather than in muscles or joints. The findings suggest fibromyalgia is related to nervous system hypersensitivity and shares genetic links with other disorders like chronic fatigue and PTSD, offering new avenues for early detection and targeted treatments.

via Earth.com|

#brain #fibromyalgia #genetics

health10 months ago•7 min saved

Effective Off-Label Treatment for Fibromyalgia Relief

Low-dose naltrexone (LDN), an old generic drug, is gaining attention as a promising off-label treatment for fibromyalgia, showing potential to reduce pain, fatigue, and brain fog, despite limited large-scale studies. Many patients and some doctors report significant benefits, and ongoing research suggests it may help manage symptoms by reducing nerve inflammation, though more rigorous trials are needed. It is often used as a last resort but could be considered earlier, with minimal side effects and low cost.

via Medscape|

#alternative-medicine #chronic-pain #fibromyalgia

health1 year ago•2 min saved

FDA Approves Tonix's Innovative Fibromyalgia and Chronic Pain Treatment

Tonix Pharmaceuticals' drug Tonmya has received FDA approval for treating fibromyalgia in adults, marking the first new therapy in over 15 years for this condition. The medication, a non-opioid, once-daily sublingual tablet, demonstrated significant pain reduction in clinical trials and is expected to be available in the US by late 2025.

via Yahoo Finance|

#chronic-pain #fda-approval #fibromyalgia

health1 year ago•2 min saved

FDA Approves First New Fibromyalgia Treatment in Over 16 Years

The FDA has approved Tonmya, a new treatment for fibromyalgia developed by Tonix Pharmaceuticals, marking the first new FDA-approved fibromyalgia drug in over 15 years. The drug is a once-daily sublingual tablet shown to significantly reduce pain in clinical trials. Following the announcement, Tonix's stock initially surged but then declined, reflecting market volatility and investor reactions.

via Investor's Business Daily|

#fda-approval #fibromyalgia #health

health1 year ago•19 min saved

Tonix's New Fibromyalgia Drug Gains FDA Approval Amid Strong Trials

Tonix Pharmaceuticals received FDA approval for Tonmya™, a non-opioid, sublingual tablet for fibromyalgia in adults, marking the first new treatment in over 15 years. The drug demonstrated significant pain reduction in Phase 3 trials and is expected to launch in Q4 2025, targeting over 10 million affected U.S. adults.

via Stock Titan|

#clinical-trials #fda-approval #fibromyalgia

health1 year ago•2 min saved

Weight Regain Common After Discontinuing GLP-1 Weight Loss Drugs

A woman with fibromyalgia experienced increased pain and inflammation after stopping Mounjaro, a medication she used for weight loss that also appeared to reduce her fibromyalgia symptoms, highlighting its potential anti-inflammatory effects beyond weight management.

via LADbible|

#fibromyalgia #health #inflammation

health1 year ago•5 min saved

New Brain Circuit Links Pain to Emotional Suffering and Fear

Researchers at the Salk Institute identified a new brain circuit involving CGRP neurons in the thalamus that mediates the emotional aspect of pain, challenging traditional views and offering potential new treatments for chronic pain and related psychiatric conditions like PTSD and migraines.

via ScienceDaily|

#brain-circuit #fibromyalgia #health

health-and-wellness2 years ago•6 min saved

"Utah Woman Shares Secrets to Losing 100 Pounds in a Year"

Angie Ehrenzweig lost 100 pounds in one year after addressing underlying health issues like fibromyalgia, insulin resistance, and metabolic syndrome with the help of Dr. Whit Roberts at Health Utah. Her journey highlights the importance of resolving health problems before effective weight loss can occur. Health Utah offers comprehensive evaluations and personalized protocols to tackle such issues, emphasizing the need for a holistic approach to weight loss.

via KSL.com|

#fibromyalgia #health-and-wellness #health-utah

health-and-wellness2 years ago•5 min saved

"Secrets to a 100-Pound Weight Loss Transformation Revealed by Local Woman"

Angie Ehrenzweig lost 100 pounds in a year with the help of Health Utah after struggling with fibromyalgia, extreme fatigue, insulin resistance, depression, systemic inflammation, and metabolic syndrome. Dr. Whit Roberts, D.C. ran a specialized scan and used a proprietary questionnaire to identify health problems contributing to her weight issues. The clinic's protocols addressed her conditions, including insulin resistance, through a combination of therapies, supplements, and dietary changes. Health Utah is offering a discounted weight loss package for two people to encourage support in weight loss journeys.

via KSL.com|

#fibromyalgia #health-and-wellness #health-utah

health2 years ago•3 min saved

"Unveiling the Mysteries of Long COVID: Key Insights and Potential Causes"

Two recent studies from UT Health Austin provide crucial insights into long COVID, helping to define its symptoms and differentiate it from other conditions. One study found that long COVID patients experienced complex and disabling symptoms, with fatigue, "brain fog," and difficulty concentrating being the most common. Another study introduced a blood test that can accurately differentiate between long COVID and fibromyalgia, offering hope for quicker and more accurate diagnoses and targeted interventions. These findings aim to improve care for the millions of individuals still grappling with the long-term effects of the pandemic.

via Medical Xpress|

#fibromyalgia #health #long-covid

health2 years ago•10 min saved

"Unraveling the Mystery of Chronic Fatigue: A Personal Journey"

A woman shares her decades-long struggle with chronic fatigue syndrome (CFS) and fibromyalgia, detailing the dismissive treatment she received from doctors and the challenges of managing her symptoms. After years of misdiagnoses, she finally received a proper diagnosis and treatment plan from a specialist, allowing her to regain some level of functioning. The article also discusses the stigma attached to CFS and the recent attention it has received due to the similarities with long-covid, shedding light on the struggles faced by those with post-viral illnesses.

via The Washington Post|

#chronic-fatigue-syndrome #diagnosis #fibromyalgia

health-and-wellness2 years ago•5 min saved

"Secrets to a 100-Pound Weight Loss Transformation Revealed by Local Woman"

Angie Ehrenzweig lost 100 pounds in a year with the help of Health Utah after struggling with fibromyalgia, extreme fatigue, insulin resistance, depression, systemic inflammation, and metabolic syndrome. Dr. Whit Roberts, D.C. used a specialized scan and questionnaire to identify her health issues and prescribed a personalized protocol for her care. The program addressed her conditions, including insulin resistance, through various methods such as herbal detoxification, supplements, infrared red light therapy, and dietary changes. Health Utah is offering a weight loss package for two people at a discounted rate to encourage support in health and weight loss journeys.

via KSL.com|

#fibromyalgia #health-and-wellness #health-utah