Tag

In Vitro

All articles tagged with #in vitro

science4 days ago•48 min saved

Five-Year Lab Brain Organoids Push the Boundaries of Maturation

Scientists grew human brain organoids in the lab for five years, finding that their biological age tracks closely with time in culture and mirrors the developmental sequence of a human brain from gestation onward. The study, which sequenced RNA every six months across 34 organoids, showed these “clumps of brain cells” can remember developmental steps and record elapsed time, a finding scientists call a time warp. While the results are unsettling, long-lived organoids offer insights for drug testing, viral effects on neurodevelopment, and brain evolution, and researchers aim to accelerate maturation even further.

via Yahoo|

#brain-maturation #brain-organoids #in-vitro

science1 month ago•6 min saved

KRAS-targeting PCAIs halt pancreatic cancer cell migration in lab study

Researchers at Florida A&M University tested polyisoprenylated cysteinyl amide inhibitors (PCAIs) against pancreatic cancer cells to disrupt mutant KRAS signaling. The leading compound NSL-YHJ-2-27 blocked more than 90% of cell migration at low concentrations, altered gene and protein markers related to movement, disrupted actin filaments, and dismantled 3D mini-tumor models; however, these findings are limited to lab studies and require animal testing and safety assessment before any human trials.

via ScienceAlert|

#in-vitro #kras #metastasis

science5 months ago•8 min saved

Lab Grows Functional Hair Follicles, Advancing Hair-Loss Treatments

Scientists have grown fully developed, functional hair follicles in the lab by adding a third cell type—accessory mesenchymal cells—alongside epithelial stem cells and dermal papilla cells. This three-cell recipe enables follicles to mature and cycle like natural hair, with potential implications for hair restoration and broader regenerative medicine, though translating the approach to humans remains a key challenge.

via Indian Defence Review|

#hair-follicles #hair-loss #in-vitro

biotechnology6 months ago•11 min saved

Lab-grown liver assembloids edge toward miniaturized human livers

Researchers combine multiple donor liver cell types to form in vitro liver assembloids that recapitulate periportal tissue, moving toward miniature human livers for faster drug testing and personalized therapies.

via Nature|

#bioengineering #biotechnology #in-vitro

science3 years ago•17 min saved

Unveiling Chikungunya Virus's Intercellular Transmission Mechanism and Potential for Vaccines

A study has found that the Chikungunya virus can be transmitted between cells through intercellular extensions, both in laboratory settings and in living organisms. These extensions, which physically connect infected and uninfected cells, facilitate the spread of the virus. The findings provide insights into the mechanisms of Chikungunya virus transmission and could potentially inform the development of intervention strategies.

via Nature.com|

#cell-to-cell-transmission #chikungunya-virus #in-vitro