
Vitamin D May Lower Diabetes Risk for People with Certain Gene Variants
Tufts researchers analyzed over 2,000 adults with prediabetes who took 4,000 IU/day of vitamin D; those with AC or CC variants of the vitamin D receptor gene had a 19% lower risk of developing diabetes versus placebo, while AA variant showed no benefit. This was a secondary analysis, not a primary randomized trial, and benefits were limited to specific genetic groups—replication is needed before changing clinical practice. Do not start high-dose vitamin D broadly; current guidelines recommend about 600–800 IU daily for most adults, with medical supervision for high doses in older adults.






