All articles tagged with #single cell rna seq
Researchers analyzed over 1.1 million tissue-resident lung immune cells from 128 donors using single-cell RNA-seq, revealing that genetic risk factors shape lung immune cell function and can drive autoimmune and inflammatory disease; thousands of risk-associated genes are active in tissue cells but not in blood, and about 1,700 genes show sex-specific expression, suggesting sex-based factors in disease susceptibility.
A multidimensional study integrating single-cell and spatial transcriptomics with live-cell imaging reveals two progenitor-like states—neuroepithelial-like and embryonic-like—and diverse spatial architectures in supratentorial ependymomas. Brain-resident cells can shift tumor cells toward neuronal-like, migratory phenotypes, highlighting developmental origins of heterogeneity and suggesting potential therapeutic angles.
This study uses dual single-cell RNA sequencing to map the development of P. falciparum in the mosquito midgut, revealing key stages, interactions with mosquito cells, and potential targets for malaria control, including validation of essential parasite genes and discovery of interactions with mosquito progenitor cells and muscles.