Tag

Small Cell Lung Cancer

All articles tagged with #small cell lung cancer

healthcare1 month ago•15 min saved

LAGOON Trial: Zepzelca Fails to Improve Survival in Second-Line SCLC

Jazz Pharmaceuticals reported top-line Phase 3 LAGOON results in relapsed (second-line) small cell lung cancer showing Zepzelca (lurbinectedin) as monotherapy or with irinotecan did not improve overall survival vs investigators' choice (topotecan or irinotecan). Safety was consistent with known profiles. The findings do not affect Zepzelca's first-line maintenance approval from IMforte and Jazz will discuss next steps with the FDA for the second-line indication; results varied by CNS involvement with no OS benefit in the overall population.

via Jazz Pharmaceuticals|

#healthcare #lagoon-trial #lurbinectedin

health10 months ago•1 min saved

Duke Researchers Uncover New Origins of Lung Cancer, Opening Doors for Innovative Treatments

Duke researchers have discovered that small cell lung cancer likely originates from basal stem cells rather than neuroendocrine cells, which could lead to earlier detection and improved treatment strategies, including immune system involvement.

via ABC11|

#cancer-origin #duke-university #health

cancer-research10 months ago•99 min saved

Small Cell Lung Cancer Exploits Brain Neuronal Synapses to Promote Growth

The article explores how neuronal activity and innervation, particularly via the vagus nerve, influence the initiation, progression, and metastasis of small cell lung cancer (SCLC), highlighting the role of neuron-tumor interactions, synaptic communication, and membrane depolarization in tumor growth within the lung and brain.

via Nature|

#brain-metastasis #cancer-research #neuronal-activity

cancer-research10 months ago•115 min saved

Small Cell Lung Cancer Exploits Neuronal Synapses to Promote Tumor Growth

The study reveals that small cell lung cancer (SCLC) forms functional synapses with neurons, particularly glutamatergic ones, which promote tumor growth. These synaptic interactions are characterized by structural and functional evidence of bona fide synapses, including electrophysiological activity and ultrastructural features. Targeting glutamate signaling with drugs like riluzole and DCPG shows promise in reducing tumor growth and improving survival in preclinical models, highlighting a novel neuro-oncological mechanism and potential therapeutic avenue.

via Nature|

#cancer-research #glutamate-signaling #neuron-cancer-interactions

healthcare10 months ago•12 min saved

Ifinatamab Deruxtecan Shows Promising Results in Small Cell Lung Cancer Trial

The Phase 2 IDeate-Lung01 trial showed that the drug ifinatamab deruxtecan achieved a 48.2% objective response rate in previously treated extensive-stage small cell lung cancer patients, with promising safety and efficacy data supporting further regulatory discussions.

via Merck.com|

#clinical-trial #daiichi-sankyo #healthcare

healthcare11 months ago•10 min saved

FDA Grants Breakthrough Status to Ifinatamab Deruxtecan for Small Cell Lung Cancer

Daiichi Sankyo and Merck's investigational drug ifinatamab deruxtecan has received FDA Breakthrough Therapy Designation for treating pretreated extensive-stage small cell lung cancer, based on promising clinical trial data, aiming to accelerate its development and approval.

via Merck.com|

#breakthrough-therapy #daiichi-sankyo #healthcare

health3 years ago•2 min saved

Unveiling the Global Fight Against Lung Cancer

Lung cancer is a common and often fatal disease, with smoking being a major risk factor. There are two main types of lung cancer: non-small cell and small cell. Common symptoms include a persistent cough, chest pain, and shortness of breath. Early detection is crucial for better survival rates. Imaging tools such as X-rays and CT scans are used to diagnose lung cancer, and treatment options include surgery, chemotherapy, radiation therapy, and targeted therapy.

via Fox News|

#health #lung-cancer #non-small-cell-lung-cancer