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Urolithin A

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King's College Study Links Pomegranate Metabolite to 80% Improvement in Heart Failure Models
health12 days ago

King's College Study Links Pomegranate Metabolite to 80% Improvement in Heart Failure Models

Researchers at King's College London have identified urolithin A, a compound produced in the body after consuming pomegranates, walnuts, and certain berries, as a potential treatment for heart failure with preserved ejection fraction (HFpEF). Published in Science Advances, the study shows that urolithin A activates the PKGIα protein, improving heart relaxation by up to 80% in animal models and engineered human heart tissue. This condition, which affects nearly half a million people in the UK, involves a stiff heart that cannot fill properly between beats, leading to fatigue and breathlessness. While current treatments are limited due to the complex nature of HFpEF, this new mechanism offers a promising therapeutic target. However, experts caution that these results are preliminary, as they are based on experimental models rather than human clinical trials. Although urolithin A has a favorable safety profile in previous human studies, further research is required to confirm its efficacy as a treatment for patients.

via sciencedaily.com|
#cardiovascular-health#clinical-trials#health
science1 month ago

Urolithin A from Pomegranates Boosts Heart Relaxation in Lab HFpEF Models

Lab studies from King’s College London show that urolithin A, a compound produced after eating pomegranates, activates PKGIα to improve heart relaxation, reduce scar tissue, and limit heart-muscle enlargement in models of heart failure with preserved ejection fraction, with functional gains up to 80%. While promising, findings are in animals and engineered human tissue; human trials are needed and dietary strategies to raise urolithin A levels are being explored, not yet a proven treatment.

via SciTechDaily|
#heart-failure#hfpef#pkgia
health1 month ago

Berry-Derived UroA Triggers Targeted Gut Repair Pathway for IBD Therapies

Researchers at the University of Louisville found that urolithin A (UroA), a microbe-produced metabolite from ellagitannins in berries, pomegranates, and walnuts, activates the aryl hydrocarbon receptor specifically in intestinal epithelial cells, engaging a controlled NLRP6 inflammasome–driven repair program that strengthens the gut barrier and mucus defenses. Demonstrated in cell models, organoids, and human IBD tissue, the work suggests a path to more targeted therapies that restore intestinal balance rather than broadly suppressing immunity. However, UroA production varies among individuals based on gut microbiota, so future approaches may need to tailor diets or microbiome interventions rather than simply advising berry-rich foods.

via SciTechDaily|
#aryl-hydrocarbon-receptor#gut-barrier#gut-microbiome
Pomegranate metabolite urolithin A improves heart relaxation in HFpEF models
health1 month ago

Pomegranate metabolite urolithin A improves heart relaxation in HFpEF models

Researchers found that urolithin A, a metabolite produced after eating pomegranates, improves heart relaxation and reduces harmful heart changes in models of heart failure with preserved ejection fraction (HFpEF) by activating the PKGIα pathway; the results in animals and engineered human heart tissue suggest a new therapeutic target, but human trials are needed and dietary pomegranate intake should not be seen as a treatment.

via News-Medical|
#health#heart-relaxation#hfpef
Gut Bacteria Turn Pomegranate Into a Plaque-Stabilizing Heart Protector
science5 months ago

Gut Bacteria Turn Pomegranate Into a Plaque-Stabilizing Heart Protector

A metabolite called urolithin A, produced by gut bacteria from pomegranate polyphenols, reduces oxidative stress and inflammation and stabilizes arterial plaques, lowering plaque size in a mouse model without changing cholesterol levels, pointing to a microbiome-based approach to cardiovascular disease; human studies are needed since individual gut microbiomes vary in producing urolithin A.

via SciTechDaily|
#atherosclerosis#gut-microbiome#plaque-stability
Pomegranates Show Promise in Alzheimer's Treatment
health2 years ago

Pomegranates Show Promise in Alzheimer's Treatment

A study from the University of Copenhagen reveals that urolithin A, a compound found in pomegranates, strawberries, and walnuts, can improve memory and potentially treat Alzheimer's disease symptoms by removing damaged mitochondria from the brain. While the research has shown promising results in mouse models, human clinical trials are planned to determine the effective dosage and potential preventive benefits.

via SciTechDaily|
#alzheimers#health#memory-improvement
Pomegranates May Hold Key to Alzheimer's Prevention and Treatment
health-and-science2 years ago

Pomegranates May Hold Key to Alzheimer's Prevention and Treatment

Researchers have found that urolithin A, a substance in pomegranates, strawberries, and walnuts, can help the brain remove damaged cells in mice with Alzheimer's disease. This process, known as mitophagy, helps clear out cellular debris that contributes to neurodegenerative diseases. While promising, further studies are needed to confirm its effects on humans and determine the appropriate dosage.

via ScienceAlert|
#alzheimers#health-and-science#mitochondria