
Interacting Medications Drive Breakthrough Strokes in Anticoagulated Atrial Fibrillation
In 1,649 AF patients on anticoagulants who had a breakthrough ischemic stroke, about 44% had identifiable causes—primarily drug interactions (28.4%) or competing non-cardioembolic etiologies. Patients with a potential cause had roughly double the 90-day risk of a new ischemic stroke (HR ~2.04), and interacting drugs were linked to a ~3.3-fold higher 90-day risk of myocardial infarction; death rates did not differ significantly. The findings suggest a need for personalized secondary prevention beyond mere anticoagulation to address alternative stroke mechanisms.












