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Cancer Drugs

All articles tagged with #cancer drugs

Pfizer inks $10B pact with Innovent to fast-track 12 cancer drugs
business1 day ago

Pfizer inks $10B pact with Innovent to fast-track 12 cancer drugs

Pfizer and Innovent announced a broad collaboration worth up to $10 billion to develop 12 cancer medicines, starting with a $650 million upfront and up to $9.85 billion in milestones. Pfizer will gain exclusive global licenses for four programs, ex-China rights to four, and co-develop four with Innovent, while Innovent handles eight programs through phase 1. The partners will co-commercialize jointly owned assets in the U.S. and Europe, illustrating how Western pharma is leveraging China’s rapid early development to boost productivity and global reach.

Exploring Cancer Drugs as Potential Alzheimer’s Therapies
health10 months ago

Exploring Cancer Drugs as Potential Alzheimer’s Therapies

Researchers are exploring the potential of repurposing cancer drugs, specifically letrozole and irinotecan, to treat Alzheimer's disease. A study identified these drugs as promising candidates that may slow or reverse symptoms in mice by altering gene expression related to the disease. While initial results are encouraging, further clinical trials are needed to assess safety and effectiveness in humans, considering the significant side effects of these drugs.

Scientists Discover Enzyme to Halt Herpes Virus's Impact on Human Genome
health11 months ago

Scientists Discover Enzyme to Halt Herpes Virus's Impact on Human Genome

Researchers in Spain have discovered that blocking the enzyme topoisomerase I can halt the replication and spread of herpes simplex virus 1 (HSV-1) by preventing it from reshaping human DNA, opening potential pathways for a cure using existing cancer drugs, which could significantly impact the treatment of this widespread and incurable virus.

"Study: Accelerated Approval Fails for Many Cancer Drugs"
healthcare2 years ago

"Study: Accelerated Approval Fails for Many Cancer Drugs"

A study found that most cancer drugs granted accelerated approval by the FDA do not demonstrate clinical benefits within five years, raising concerns about patient access to unproven medications. Despite the program's intention to speed access to promising drugs, only 43% of the drugs demonstrated a clinical benefit in confirmatory trials, yet 63% were converted to regular approval. The study highlights the need for better communication of uncertainty to patients and the importance of careful explanation by doctors. Recent updates to the program give the FDA more authority to withdraw drugs when companies don't meet their commitments, aiming to streamline the process for verifying drug efficacy.

"Study Reveals Lack of Evidence for Many Accelerated Approval Cancer Drugs"
health-medicine2 years ago

"Study Reveals Lack of Evidence for Many Accelerated Approval Cancer Drugs"

A study found that most cancer drugs granted accelerated approval by the FDA do not demonstrate clinical benefits within five years, despite the program being intended to give patients early access to promising drugs. Between 2013 and 2017, 63% of cancer drugs granted accelerated approval were converted to regular approval, even though only 43% demonstrated a clinical benefit in confirmatory trials. The study raises concerns about whether patients understand the uncertainty surrounding drugs with accelerated approval and emphasizes the importance of doctors carefully explaining the evidence to patients. Congress recently updated the program, giving the FDA more authority and streamlining the process for withdrawing drugs when companies don’t meet their commitments.

"Space-Made Cancer Drugs and Moonshot Progress: First Lady Unveils Expansion Plan"
healthtech2 years ago

"Space-Made Cancer Drugs and Moonshot Progress: First Lady Unveils Expansion Plan"

BioOrbit, founded by Katie King, plans to revolutionize cancer drug production by crystallizing proteins in microgravity in space, allowing for higher drug concentrations and easier administration. The company aims to commercialize this process after securing funding from the European Space Agency and plans to test it on the International Space Station. While there are challenges such as cost and regulation, King sees the potential for microgravity to significantly benefit drug development and hopes to establish a permanent facility in space for research and manufacturing.

"Pfizer's Strategic Shift: Prioritizing Cancer Drugs Over COVID Business Decline"
business2 years ago

"Pfizer's Strategic Shift: Prioritizing Cancer Drugs Over COVID Business Decline"

Pfizer is shifting focus to cancer drugs after a decline in its COVID-19 business, aiming to expand its oncology portfolio and increase blockbuster medicines from five to eight by 2030. The company acquired oncology biotech firm Seagen for $43 billion, doubling its cancer drug pipeline to 60 programs. Analysts foresee challenges due to competitive pressure and upcoming patent losses, but Pfizer aims to generate $10 billion in oncology sales by 2030. The move follows a turbulent year in 2023, with a 41% revenue decline attributed to the expected drop in COVID-19 revenues.