Tag

Cell Signaling

All articles tagged with #cell signaling

science8 hours ago•60 min saved

Arrestin condensates orchestrate GPCR signaling through liquid–liquid phase separation

New research shows beta-arrestins 1 and 2 form endogenous condensates near activated GPCRs via liquid–liquid phase separation, a process regulated by IP6-induced oligomerization and the arrestin intrinsically disordered region. These condensates influence GPCR desensitization, internalization, and downstream signaling, with arrestin orientation and specific mutations (IP6 sites and IDR) altering function, suggesting LLPS compartments are important regulators of GPCR signaling and could inform drug development.

via Nature|

#beta-arrestin #cell-signaling #condensates

science7 months ago•8 min saved

Scientists Uncover Plants' Hidden Language

Scientists are uncovering the complex, active communication system of plant cell walls, which play a crucial role in growth, defense, and adaptation. Advances in molecular biology reveal how cell wall components like pectin and cellulose send signals that influence plant shape and resilience, opening new possibilities for crop improvement and sustainable agriculture.

via Nature|

#agriculture #cell-signaling #pectin

science7 months ago•5 min saved

Memories Found to Be Stored Throughout the Body

Scientists discovered that memories are stored not only in the brain but also in other body cells, with spaced chemical signals enhancing and prolonging cellular responses, suggesting that learning principles like timing and pattern are fundamental to all cells, not just neurons.

via Earth.com|

#cell-signaling #learning #memory

science8 months ago•24 min saved

Enhanced Immunotherapy Through Proximity Labeling Techniques

The article discusses a study on enhancing antigen-induced cellular responses using proximity labelling techniques, with data available from various repositories and analysis code on GitHub, highlighting advances in immune signaling and proteomics methods.

via Nature|

#cell-signaling #immune-response #proteomics

health10 months ago•6 min saved

Enzyme Blockade Reverses Parkinson’s Cell Damage in New Study

Scientists discovered that inhibiting the overactive enzyme LRRK2 in mice with a Parkinson's-related mutation can restore damaged brain cells, regrow cellular antennae called cilia, and improve dopamine signaling, suggesting a potential approach to reverse early Parkinson’s damage.

via SciTechDaily|

#cell-signaling #enzyme-inhibition #health

science-and-technology2 years ago•3 min saved

"Groundbreaking Discovery: Unprecedented Brain Signal Detected"

Scientists have discovered a unique form of cell messaging in the human brain, involving a novel 'graded' signal produced by cortical cells using calcium ions, leading to the identification of calcium-mediated dendritic action potentials (dCaAPs). This finding suggests that individual neurons in the human brain may have more computational power than previously thought, potentially allowing for exclusive OR (XOR) intersections. Further research is needed to understand the implications of this discovery and its potential applications in both neuroscience and technology.

via ScienceAlert|

#brain-research #cell-signaling #human-brain

science2 years ago•4 min saved

Mitochondria's SOS: How They Signal for Help Under Stress

Researchers at Goethe University Frankfurt have discovered how mitochondria communicate with the cell when under stress. Mitochondria release reactive oxygen compounds and block the import of protein precursors, causing them to accumulate in the cell. This triggers a chemical change in a protein called DNAJA1, which then interacts with the folding assistant HSP70. HSP70 takes care of the misfolded protein precursors, reducing its interaction with its regular partner HSF1. HSF1 is then released and can trigger the cell's anti-stress mechanism for the mitochondria. The study sheds light on the intricate signaling pathways between mitochondria and cells during times of stress.

via Phys.org|

#cell-signaling #cellular-response #cellular-stress