All articles tagged with #proteomics
A Swiss study analyzing blood from centenarians (100–105) found 37 of 724 serum proteins resemble those of younger people, suggesting key aging mechanisms can slow rather than stop; centenarians show lower oxidative stress markers, more youthful extracellular-matrix proteins, and a metabolism that remains balanced, with lifestyle factors highlighted as a powerful longevity lever.
A proteomics study of 516 samples from 76 organ donors aged 14–68 finds an aging inflection around age 50, with vascular tissues like the aorta aging fastest. The team built tissue-specific aging clocks across seven body systems, mapped organ aging trajectories, and identified disease-related protein changes that rise with age. Notably, most remodeling occurs between ages 45–55. In a mouse experiment, a protein linked to vascular aging induced declines in physical performance, underscoring the aorta and blood vessels as early aging targets. The work aims to create a comprehensive multi-tissue aging atlas to guide interventions for age-related diseases.
Researchers combined multispectral imaging and proteomics to study two 1531 Renaissance medical manuals, uncovering faded text and protein traces from readers’ hands. The marginalia show extensive at‑home experimentation with vernacular remedies, including both common ingredients and exotic compounds like hippopotamus teeth; proteomics also detected immune-related proteins, illustrating how Renaissance knowledge blended practical tinkering with book knowledge. The work demonstrates a new way to contextualize historical recipes and could scale to more collections.
A study analyzing 516 tissue samples from 76 organ donors aged 14–68 shows rapid aging begins around age 50, with different organs aging at different rates. The findings support aging as a systemic, nonuniform process and highlight the need for further research. In the meantime, NIH/CDC guidance emphasizes regular exercise, a nutrient-rich diet, portion control, and social engagement to maintain health and quality of life into later years.
Researchers used advanced scDVP to profile hundreds of hepatocytes from 18 people, building a high-resolution map of protein gradients along the liver's porto–central axis. They quantified ~2,500 proteins per cell, showed roughly half are zonated, and introduced gradient-based analysis to quantify zonation without binning. Cross-species comparison with mice revealed shared and human-specific zonation features; in tissues with disrupted architecture, zonation is broadly lost. The study delivers an open-access liver proteome resource and a framework applicable to spatial proteomics.
A proteomics analysis of Bartholomäus Vogtherr’s 1531 medical manuals recovered 111 proteins from the pages, including traces that could match plants (beech, watercress, rosemary) and animals (lizard, tortoise shell, hippopotamus). Notably, protein near hair-growth recipes suggests readers experimented with lizard heads for hair loss and hippo-derived ingredients for dental/mouth issues, illustrating how Renaissance readers tested unconventional cures and shedding light on early modern household science, per a study in the American Historical Review.
The article discusses a study on enhancing antigen-induced cellular responses using proximity labelling techniques, with data available from various repositories and analysis code on GitHub, highlighting advances in immune signaling and proteomics methods.
This study explores the proteogenomic landscape of the human kidney and discusses its implications for cardio-kidney-metabolic health, providing data resources and analysis tools for further research.
A new study reveals that human aging accelerates around age 50, with organs aging at different rates, notably the aorta which may influence systemic aging through proteins like GAS6. The research highlights aging as a phased process with molecular upheavals, offering potential for targeted interventions and biomarkers to track organ-specific decline.
A groundbreaking study reveals that insulin resistance and type 2 diabetes are more complex than previously thought, with individual molecular signatures in muscle tissue influencing insulin sensitivity. This research paves the way for personalized diagnosis and treatment, moving beyond traditional blood tests to early detection through muscle protein analysis, potentially transforming diabetes management worldwide.
The GNPC identified a shared five-protein biomarker profile across Alzheimer's, Parkinson's, frontotemporal dementia, and ALS, which predicts APOE ε4 status with high accuracy, offering new avenues for understanding and potentially treating these diseases, though causality remains unproven.
Paleontologists have discovered preserved ancient proteins in a 24-million-year-old rhinoceros fossil, challenging previous timelines of rhino evolution and demonstrating the potential of protein analysis to study deep past species beyond the limits of ancient DNA, thereby opening new avenues for understanding evolutionary history.
Recent research has expanded the understanding of molecular glue degraders, revealing that they can target a much wider array of proteins than previously thought, including those with surface features beyond the beta-hairpin loop motif, opening new possibilities for drug development against previously 'untouchable' proteins.
Illumina is acquiring SomaLogic for $350 million to enhance its proteomics capabilities and advance its multiomics strategy, leveraging SomaLogic's data-driven proteomics technology to expand in a high-growth market and integrate with Illumina's sequencing ecosystem.
Researchers are developing an $800 blood test that measures proteins to assess real-time organ health and aging, potentially revolutionizing personalized medicine and early disease detection, with some clinics already using similar tests to guide health interventions.