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Fecal Microbiota Transplantation

All articles tagged with #fecal microbiota transplantation

health13 days ago•4 min saved

Gut microbiome therapy shows early promise for peanut allergy

A small phase 1 trial suggests oral fecal microbiota transplantation from healthy donors may increase peanut tolerance in some adults with peanut allergy (6 of 15 participants across two stages). Safety was acceptable, and mouse studies supported a gut-bacteria–driven mechanism involving RORγt+ regulatory T cells and bile acid metabolites. While encouraging, results are preliminary and not ready for clinical use; researchers aim to develop purified microbiome therapies (MTT) and conduct larger trials over the coming years. In the meantime, standard care—strict avoidance and an emergency allergy plan—remains essential.

via Healthline|

#clinical-trial #fecal-microbiota-transplantation #gut-microbiome

health25 days ago•143 min saved

Gut bacteria transplant pills show early sleep gains in insomnia study

In a small Chinese trial, adults with chronic insomnia received antibiotics to clear gut bacteria and then 60 fecal microbiota transplantation capsules from healthy donors, followed by a booster 2 weeks later. The treated group showed a jump in sleep efficiency from about 79% to 93% at one month and fewer awakenings, while the placebo group changed little. Researchers consider the findings encouraging but note the study’s small size and the combination of antibiotics with FMT, so more research is needed before this approach could be considered routine treatment.

via livescience.com|

#clinical-trial #fecal-microbiota-transplantation #gut-microbiome

health7 months ago•2 min saved

Pill-Based Donor Microbes Show Early Promise in Boosting Cancer Immunotherapy

Two small Nature Medicine trials suggest oral fecal microbiota transplantation (FMT) pills may boost immunotherapy in advanced cancers: in metastatic kidney cancer, FMT reduced immunotherapy side effects and produced about a 50% response; in advanced lung cancer or melanoma, combining FMT with immunotherapy yielded response rates around 75–80%, higher than typical 39–45% rates. While promising, results are early and require larger trials.

via Gizmodo|

#cancer-immunotherapy #fecal-microbiota-transplantation #health

health7 months ago•11 min saved

Fecal Transplants Boost Immunotherapy Responses and Cut Side Effects in Cancer Trials

Two Nature Medicine studies show that fecal microbiota transplantation (FMT) capsules can both reduce immunotherapy-related toxicity in kidney cancer and improve response rates in lung cancer and melanoma—80% of lung cancer patients and 75% of melanoma patients responded to immunotherapy after FMT (significantly higher than immunotherapy alone) in multicenter Phase II trials using LND101 capsules.

via News-Medical|

#fecal-microbiota-transplantation #health #immunotherapy

health7 months ago•86 min saved

Healthy-donor fecal transplants boost frontline immunotherapy responses in NSCLC and melanoma

In the phase 2 FMT-LUMINate trial, healthy-donor fecal microbiota transplantation given before first-line anti-PD-1 therapy in NSCLC and anti-PD-1 plus anti-CTLA-4 in melanoma yielded high objective response rates (80% in NSCLC; 75% in melanoma) and was deemed safe overall, with no grade 3+ adverse events in NSCLC. Post-FMT microbiome shifts correlated with responses, including the loss of certain deleterious bacteria (e.g., Enterocloster and Clostridium species). Donor source did not predict efficacy, suggesting that remodeling the gut microbiome—specifically eliminating harmful taxa—drives the benefit. Preclinical mouse data supported this mechanism, showing that reintroducing the lost taxa abrogated the anti-tumor effects of immunotherapy. These findings support FMT as a strategy to overcome resistance to checkpoint inhibitors in NSCLC and melanoma.

via Nature|

#fecal-microbiota-transplantation #health #immunotherapy

health2 years ago•3 min saved

"Fecal Microbiota Transplant Improves Parkinson's Symptoms"

A groundbreaking clinical study conducted by researchers at Ghent University Hospital in Belgium has shown promising evidence that fecal microbiota transplantation (FMT) could improve symptoms in patients with Parkinson's disease. The study, named the GUT-PARFECT trial, demonstrated that participants who received healthy donor stool transplants showed significant improvement in motor symptoms and experienced less constipation after 12 months. The researchers believe that FMT could be a valuable new treatment for Parkinson's disease and are seeking funding for further research to determine which bacteria have a positive influence, potentially leading to the development of targeted therapies.

via The Jerusalem Post|

#fecal-microbiota-transplantation #ghent-university-hospital #health

health2 years ago•6 min saved

"Parkinson's Symptoms Improved with Fecal Bacteria Transplant"

A clinical trial has shown that fecal microbiota transplantation (FMT) may significantly improve motor symptoms in patients with Parkinson’s disease (PD) by transplanting healthy donor stool into patients with early-stage PD, leading to marked improvements in motor functions and reductions in constipation over 12 months. The study highlights the potential of FMT as a new treatment for PD and underscores the emerging link between the gut microbiome and neurodegenerative diseases, suggesting that gut bacteria play a crucial role in the development and symptomatology of PD.

via Neuroscience News|

#clinical-trial #fecal-microbiota-transplantation #gut-microbiome

health2 years ago•3 min saved

"Promising Results: Stool Transplant as Treatment for Parkinson's Disease"

A clinical study conducted by researchers at Ghent University Hospital, VIB, and Ghent University has shown promising results for using fecal microbiota transplantation (FMT) to improve symptoms in patients with Parkinson's disease. The study, named GUT-PARFECT, demonstrated that participants who received healthy donor stool transplants showed significant improvement in motor symptoms and reduced constipation over a 12-month period. This research suggests that FMT could be a valuable new treatment for Parkinson's disease, offering a potentially safe, effective, and cost-effective way to improve symptoms and quality of life for millions of people worldwide. Further research is needed to determine the long-term effects and potential development of targeted therapies.

via Medical Xpress|

#fecal-microbiota-transplantation #gut-microbiome #health

health2 years ago•6 min saved

Success Story: Woman Cures Ulcerative Colitis with Over 100 Stool Transplants

Saffron Cassaday, who had been suffering from ulcerative colitis for 15 years, successfully treated her condition by performing over 100 DIY fecal microbiota transplants (FMT) using her partner's stool. FMT involves transferring a screened donor's healthy microbes and bacteria to a patient via an enema. While FMT has been proven effective for treating C. diff infections, its efficacy for ulcerative colitis is lower, with only about 25% of patients experiencing improvement. FMT is currently being studied in over 200 clinical trials for various conditions, but caution is advised, and it should only be done in a clinical setting.

via Yahoo Life|

#autoimmune-disease #clinical-trials #diy-treatment

health3 years ago•3 min saved

FDA Approves Revolutionary Fecal Transplant Pill for Gut Infections.

The FDA has approved Vowst, an oral capsule containing beneficial bacteria derived from human fecal matter, to treat recurrent infections of Clostridioides difficile by balancing out the gut microbiome. Vowst was approved on the basis of two studies conducted in the U.S. and Canada, including a randomized, double-blinded placebo-controlled trial. The drug is intended to be used in conjunction with antibiotics to prevent recurrent C. difficile infections and is taken four capsules at a time daily for three days.

via Gizmodo|

#c-difficile #fda #fecal-microbiota-transplantation

health3 years ago•3 min saved

The Gut Microbiome's Role in Anorexia Nervosa.

A study published in Nature Microbiology has identified the mechanistic interplay between restricted eating habits and how the gut microbiota's natural response negatively accentuates the pathology of anorexia nervosa (AN). The study found that altered serum metabolite compounds could indicate the compounds are operating via blood circulation, affecting brain regulation of appetite, emotions, and behavior. Additionally, fecal microbiota transplantation from AN cases to germ-free mice under energy-restricted feeding mirrored AN eating behaviors. The gut virome was also altered in the AN group, as researchers noted a reduction in viral–bacterial interactions.

via Medical Xpress|

#anorexia-nervosa #fecal-microbiota-transplantation #gut-microbiome