Tag

Immunomodulation

All articles tagged with #immunomodulation

health-and-medicine1 month ago•6 min saved

Plant-derived compound slows rheumatoid arthritis in rats by rebalancing fatty acid metabolism

A plant-derived compound called obakulactone (OL) alleviates arthritis symptoms and joint damage in a rat model of RA by promoting ACOT1 degradation via the ubiquitin–proteasome pathway, correcting disrupted unsaturated fatty acid metabolism, and modulating immune cells and inflammatory signals. The study identifies ACOT1 as a potential drug target and suggests a new preclinical strategy for RA, though its safety and efficacy in humans remain to be tested.

via ScienceDaily|

#acot1 #fatty-acid-metabolism #health-and-medicine

science4 months ago•38 min saved

Targeted immunosuppressive dendritic cells blunt cardiac fibrosis after injury

Engineered FAP-targeted immunosuppressive dendritic cells (iCDCs), carrying IL-10, CTLA4-Ig, and PD-L1, reprogram local immune responses to reduce inflammation and fibrosis after myocardial injury in mice and improve heart function, with additional benefit in a non-human primate MI model and no systemic toxicity; mechanism includes direct suppression of immune/stromal cell activation and indirect expansion of regulatory T cells. This lesion-targeted immune modulation presents a promising therapy for cardiac remodeling and heart failure. Data and code are publicly available.

via Nature|

#cardiac-fibrosis #cardiac-remodeling #dendritic-cells

health1 year ago•4 min saved

Spleen as a Promising Site for Islet Transplantation in Diabetes Treatment

Researchers have developed a novel spleen-based method for islet transplantation that uses nanoparticle-driven remodeling to create an immune-friendly environment, enabling long-term glycemic control in diabetic animals without full immunosuppression, offering a promising alternative to traditional liver-based transplants.

via Medical Xpress|

#diabetes #health #immunomodulation

medical-science3 years ago•19 min saved

Enhancing Parkinson's stem-cell therapy with autologous Treg cells

Researchers have conducted a study on the co-transplantation of autologous regulatory T (Treg) cells in a cell therapy for Parkinson's disease. The study showed that the co-transplantation of Treg cells with induced pluripotent stem cell (iPSC)-derived dopaminergic progenitor cells improved motor function and reduced depressive behaviors in parkinsonian monkeys. Treg cells have immunomodulatory properties and can potentially enhance the survival and function of transplanted cells. This research highlights the potential of combining Treg cells with cell-based therapies for Parkinson's disease.

via Nature.com|

#autologous-transplant #cell-therapy #immunomodulation