
Scratch Less: Research Links Itching to Increased Inflammation in Eczema
University of Pittsburgh researchers show that scratching an itch activates mast cells to release histamine and substance P, boosting inflammation and prolonging the itch-scratch cycle in an eczema-like mouse model; mice prevented from scratching or lacking itch-sensing neurons had less inflammation, while scratching altered the skin microbiome, suggesting itching evolved partly to defend against infection but worsens chronic dermatitis. Cold compresses and 1% hydrocortisone cream can help relieve itching.










