Tag

Neoantigens

All articles tagged with #neoantigens

health4 days ago•35 min saved

Phase 1 Trial Shows Personalized Neoantigen Vaccines Safe and Biologically Active in Ovarian Cancer

A phase 1 trial published in Nature Medicine demonstrates that personalized neoantigen-targeting vaccines are safe and show signs of biological activity in patients with high-grade epithelial ovarian cancer. The study, involving ten patients, found no unexpected safety signals and indicated that the vaccine induced immune responses in a majority of participants, suggesting potential clinical efficacy.

via Nature|

#clinical-trials #health #immunotherapy

health5 months ago•11 min saved

Tailored DNA Vaccine Extends Survival in Aggressive Glioblastoma

A phase 1 trial of GNOS-PV01, a personalized DNA vaccine for unmethylated MGMT glioblastoma, is safe and elicits broad immune responses by targeting up to 40 patient-specific neoantigens, transforming the tumor microenvironment from cold to hot and reducing the likelihood of tumor escape; results show two-thirds progression-free at six months and two-thirds overall survival at one year, with one patient recurrence-free nearly five years post-diagnosis, supporting larger trials and expansion to all GBM types.

via Neuroscience News|

#dna-vaccine #glioblastoma #health

medical-research5 months ago•15 min saved

Tailored DNA vaccine sparks immune response against glioblastoma in early trial

A phase 1 trial at Siteman Cancer Center shows a personalized neoantigen DNA vaccine (GNOS-PV01) for glioblastoma is safe and elicits robust immune responses; among nine patients, about two-thirds had no progression at six months and two-thirds were alive at one year, including a long-term recurrence-free survivor, indicating potential benefit and the need for larger trials.

via WashU Medicine|

#dna-vaccine #glioblastoma #immunotherapy

cancer-research11 months ago•59 min saved

Key Genetic and Epigenetic Factors Drive Early Bowel Cancer Development

This study explores how epigenetic changes and immune microenvironment interactions drive early immune evasion in colorectal cancer, highlighting chromatin architecture's role in suppressing neoantigen expression and the importance of early immune escape mechanisms in tumor evolution.

via Nature|

#cancer-research #colorectal-cancer #epigenetics

health3 years ago•2 min saved

Advancements in Pancreatic Cancer Vaccines and Treatments.

A clinical trial has reported promising results from testing a personalized approach to boosting immune responses to pancreatic tumours. Pancreatic cancers generally don’t respond to immune-checkpoint inhibitors (ICIs) because they express lower levels of neoantigens than other types of tumours, and thus are less likely to activate a strong immune response from antitumour T cells. However, the trial found that a vaccine that boosts T cells that target neoantigens in pancreatic tumours could be effective in treating the disease.

via Nature.com|

#clinical-trial #health #immunotherapy