Tag

Neural Development

All articles tagged with #neural development

science7 days ago•48 min saved

Five-Year Lab Brain Organoids Push the Boundaries of Maturation

Scientists grew human brain organoids in the lab for five years, finding that their biological age tracks closely with time in culture and mirrors the developmental sequence of a human brain from gestation onward. The study, which sequenced RNA every six months across 34 organoids, showed these “clumps of brain cells” can remember developmental steps and record elapsed time, a finding scientists call a time warp. While the results are unsettling, long-lived organoids offer insights for drug testing, viral effects on neurodevelopment, and brain evolution, and researchers aim to accelerate maturation even further.

via Yahoo|

#brain-maturation #brain-organoids #in-vitro

science2 months ago•82 min saved

Neuronal migration causes non-lethal DNA breaks via mechanical stress

During brain development, migrating neurons experience mechanical stress as they squeeze through narrow spaces, triggering widespread DNA double-strand breaks without nuclear envelope rupture. Breaks arise from TOP2β–DNA cleavage complexes and are repaired mainly by non-homologous end joining; damage concentrates in transcriptionally inactive chromatin and retrotransposons. In mice with early Lig4 loss in migrating neurons, DSBs persist with mild transcriptional changes and age‑related motor deficits, suggesting developmental DNA damage can subtly affect brain function and disease risk.

via Nature|

#cerebellum #dna-damage #neural-development

science4 months ago•5 min saved

Glowing Quail Embryos Reveal How Neural Tubes Form

Researchers used genetically modified fluorescent quail embryos to watch neural tube formation in real time, discovering that PRICKLE1 governs up-down cell movements rather than left-right cues—an insight that could guide genetic screening and therapies for neural tube defects affecting hundreds of thousands of pregnancies annually.

via The Conversation|

#fluorescence-imaging #neural-development #neural-tube-defects

science10 months ago•28 min saved

Neuroscientist Dale Purves Explains Brain Function

Dale Purves, a renowned neuroscientist, explores how the brain constructs our perception of reality through associations and experiences, emphasizing that sensory information is inherently inaccurate and that our understanding of the world is shaped by learned patterns rather than direct, objective data. His work spans neural development, perception, and the relationship between brain structure and function, challenging traditional views and highlighting the importance of experience in shaping our mental and perceptual worlds.

via Aeon|

#brain-perception #neural-development #neuroscience