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Pharmacology

All articles tagged with #pharmacology

science9 days ago

Designer miniproteins target GPCRs with high precision

Nature reports computational de novo design of miniproteins that bind G protein-coupled receptors (GPCRs) with high affinity, enabling both agonists for itch/pain receptors and antagonists for cancer, metabolic disorders, and migraine. Cryo-EM structures of five receptor–miniprotein complexes closely match the design models, validating the approach, and a designed chemokine receptor antagonist mobilizes hematopoietic stem and progenitor cells in vivo with fewer adverse effects than a clinically used drug.

via Nature|
#cryo-em#de-novo-design#gpcr
Evolution of Anxiety Treatments Over the Past 70 Years
health6 months ago

Evolution of Anxiety Treatments Over the Past 70 Years

Over the past 70 years, anxiety treatments have evolved from tranquilizers like Miltown in the 1950s to benzodiazepines in the 1960s-70s, and then to SSRIs and SNRIs from the 1980s-2000s, with no new medications approved since 2004. Despite slowed innovation, existing treatments have been refined, and new approaches are in development, but effective, long-term solutions for everyone remain a challenge.

via Our World in Data|
#anxiety#health#medication-evolution
How Foods Interfere with Your Medications
health9 months ago

How Foods Interfere with Your Medications

Foods can significantly interfere with medications, either enhancing or inhibiting their effects, as seen with grapefruit, cranberry juice, and herbs like turmeric. While some interactions pose risks of toxicity or reduced efficacy, researchers are exploring ways to harness these effects to improve treatment outcomes, emphasizing the importance of understanding individual food-drug interactions for safer and more effective therapies.

via BBC|
#food-drug-interactions#gastrointestinal#health
"Surprising Genetic Abundance Found in Poisonous Invasive Plant"
science2 years ago

"Surprising Genetic Abundance Found in Poisonous Invasive Plant"

Scientists have studied the genome of Sosnowsky's hogweed, an invasive plant known for its poisonous juice that causes skin burns. They discovered that the plant has nearly twice as many genes as most other plants, with 55,000 genes compared to the usual 25,000-35,000. The researchers found that gene duplications are responsible for this phenomenon. The unique bioactive molecules found in hogweed could have practical applications in medicine and pharmacology, potentially leading to the development of new drugs. Understanding the plant's genome could also aid in the development of control and monitoring methods for this invasive species.

via Phys.org|
#bioactive-molecules#genome#invasive-plant
The Potential Risks of Lorazepam in Pancreatic Cancer Treatment
medical-research2 years ago

The Potential Risks of Lorazepam in Pancreatic Cancer Treatment

A study conducted by researchers at the Roswell Park Comprehensive Cancer Center has found that the use of lorazepam, a commonly prescribed anti-anxiety medication, stimulates the production of IL6, a pro-inflammatory cytokine, in pancreatic cancer cells. The study also revealed that higher levels of IL6 were associated with poorer survival outcomes in patients with pancreatic cancer. These findings suggest a potential link between lorazepam use, IL6 production, and disease progression in pancreatic cancer, highlighting the need for further research in this area.

via Cancer Discovery|
#il6-production#lorazepam#medical-research