Tag

Pharmacology

All articles tagged with #pharmacology

health21 hours ago•51 min saved

Mind-Blowing Medical Facts Med Students Still Talk About

A BuzzFeed health roundup collects 19 astonishing medical facts that med students say blew their minds, covering everything from direct outside-to-peritoneal pathways and pregnancies occurring with only one ovary and one fallopian tube on opposite sides, to neutrophil extracellular traps (NETs), real-time cerebellar motor plan updates, and bone-marrow transplants as stem-cell reinfusions. The list also highlights the body’s cancer surveillance, amniotic-fluid origins, and other surprising bits of anatomy, physiology, and pharmacology, drawing on sources like StatPearls, PubMed, ASH, and WHO to showcase the awe-inspiring complexity of the human body.

via Yahoo|

#anatomy #health #immunology

science2 months ago•18 min saved

Designer miniproteins target GPCRs with high precision

Nature reports computational de novo design of miniproteins that bind G protein-coupled receptors (GPCRs) with high affinity, enabling both agonists for itch/pain receptors and antagonists for cancer, metabolic disorders, and migraine. Cryo-EM structures of five receptor–miniprotein complexes closely match the design models, validating the approach, and a designed chemokine receptor antagonist mobilizes hematopoietic stem and progenitor cells in vivo with fewer adverse effects than a clinically used drug.

via Nature|

#cryo-em #de-novo-design #gpcr

health8 months ago•14 min saved

Evolution of Anxiety Treatments Over the Past 70 Years

Over the past 70 years, anxiety treatments have evolved from tranquilizers like Miltown in the 1950s to benzodiazepines in the 1960s-70s, and then to SSRIs and SNRIs from the 1980s-2000s, with no new medications approved since 2004. Despite slowed innovation, existing treatments have been refined, and new approaches are in development, but effective, long-term solutions for everyone remain a challenge.

via Our World in Data|

#anxiety #health #medication-evolution

health11 months ago•11 min saved

How Foods Interfere with Your Medications

Foods can significantly interfere with medications, either enhancing or inhibiting their effects, as seen with grapefruit, cranberry juice, and herbs like turmeric. While some interactions pose risks of toxicity or reduced efficacy, researchers are exploring ways to harness these effects to improve treatment outcomes, emphasizing the importance of understanding individual food-drug interactions for safer and more effective therapies.

via BBC|

#food-drug-interactions #gastrointestinal #health

science11 months ago•1 min saved

Flatworms Offer Hope for Schizophrenia Treatment

Research at the University of Reading suggests that flatworms called planaria could be used to study mental health treatments like schizophrenia, potentially replacing rodents in experiments and reducing ethical concerns, as they react to brain medicines similarly to rodents.

via BBC|

#animal-welfare #flatworms #mental-health

history1 year ago•6 min saved

Caligula: Madman or Medical Expert?

A Yale study suggests that Caligula, often seen as a mad and cruel Roman emperor, was actually knowledgeable about medicine, particularly hellebore treatments used in ancient Greece, indicating a more nuanced understanding of his character and medical practices of the time.

via Phys.org|

#ancient-medicine #caligula #history

health1 year ago•5 min saved

Eolo Pharma's New Obesity Drug Promotes Fat Burn Without Appetite Suppression

A new experimental obesity drug called SANA, derived from salicylate, may promote weight loss by increasing energy expenditure through creatine-dependent thermogenesis without suppressing appetite, showing promising results in a small human trial and offering a potential alternative to current GLP-1 based treatments.

via WIRED|

#creatine-thermogenesis #health #obesity

science2 years ago•3 min saved

"Surprising Genetic Abundance Found in Poisonous Invasive Plant"

Scientists have studied the genome of Sosnowsky's hogweed, an invasive plant known for its poisonous juice that causes skin burns. They discovered that the plant has nearly twice as many genes as most other plants, with 55,000 genes compared to the usual 25,000-35,000. The researchers found that gene duplications are responsible for this phenomenon. The unique bioactive molecules found in hogweed could have practical applications in medicine and pharmacology, potentially leading to the development of new drugs. Understanding the plant's genome could also aid in the development of control and monitoring methods for this invasive species.

via Phys.org|

#bioactive-molecules #genome #invasive-plant

medical-research2 years ago•5 min saved

The Potential Risks of Lorazepam in Pancreatic Cancer Treatment

A study conducted by researchers at the Roswell Park Comprehensive Cancer Center has found that the use of lorazepam, a commonly prescribed anti-anxiety medication, stimulates the production of IL6, a pro-inflammatory cytokine, in pancreatic cancer cells. The study also revealed that higher levels of IL6 were associated with poorer survival outcomes in patients with pancreatic cancer. These findings suggest a potential link between lorazepam use, IL6 production, and disease progression in pancreatic cancer, highlighting the need for further research in this area.

via Cancer Discovery|

#il6-production #lorazepam #medical-research