Tag

Plasticity

All articles tagged with #plasticity

science14 days ago•29 min saved

Reactivating brain circuits reverses autism-like symptoms in mice by restoring neuron structure

A mouse model of autism with a 15q11-13 duplication showed shortened axon initial segments in prefrontal neurons, reducing excitability. Chemogenetic activation of a circuit from the medial prefrontal cortex to the dorsal raphe nucleus lengthened the AIS, normalized sodium-channel components, and markedly improved social interaction while reducing repetitive digging. The AIS changes appeared reversible, suggesting they are a flexible, circuit-level biomarker rather than permanent damage. While promising, the findings are limited to mice and one autism model, and researchers call for live-cell imaging and broader models before considering human translation.

via PsyPost|

#autism #axon-initial-segment #chemogenetics

science4 months ago•54 min saved

Tropical insects approach a thermal ceiling, signaling limited buffering against warming

A global study measured CTmax and CTmin for about 2,300 tropical insects across Afrotropical and Neotropical elevational gradients, finding that thermal limits do not track environmental temperatures and instead approach a tropical lowland ceiling. High-elevation species show plasticity to rising heat, while lowland species have limited plastic responses; heat tolerance also varies markedly among insect orders and aligns with protein stability via protein melting temperatures. Heat-shock tests indicate CTmax can increase at high elevations but may decrease tolerance in warm lowlands. Using field data and climate projections, the authors predict that up to ~52% of future surface temperatures and ~38% of future air temperatures in Amazonian lowlands could cause heat mortality for half the studied community, suggesting tropical insects have a limited capacity to buffer future warming.

via Nature|

#climate-change #plasticity #protein-melting-temperature

neuroscience7 months ago•109 min saved

Astrocyte CCN1 Enhances Stability of Adult Neural Circuits

The study identifies astrocyte-secreted CCN1 as a key factor in maintaining neural circuit stability in the adult brain, particularly in the visual cortex, by regulating synaptic maturation, inhibitory neuron development, and oligodendrocyte maturation, thereby restricting plasticity and preserving functional connectivity.

via Nature|

#astrocytes #ccn1 #neural-circuit-stability

neuroscience2 years ago•5 min saved

"Unpredictable Reactions: Neurons' Surprising Responses"

New research from the Netherlands Institute for Neuroscience reveals that chandelier cells, a unique type of brain cell, become active during unexpected events, playing a crucial role in signaling and adaptation in response to surprising stimuli. The study used a novel mouse model to observe and understand the behavior of chandelier cells, showing their sensitivity to unexpectedness, habituation, and structural changes in synaptic connections. This comprehensive study sheds light on the role of these inhibitory neurons in the cortex, crucial for processes such as learning from unexpected circumstances.

via Neuroscience News|

#brain-cells #chandelier-cells #learning

science2 years ago•3 min saved

Reevaluating Newborn Brain Development: Surprising Insights into Human Evolution

A study led by researchers at University College London challenges the belief that human newborns have less developed brains compared to other primates. The study found that humans are born at a typical development level for primates, but their brains undergo significant growth after birth, giving the impression of underdevelopment. This discovery alters the understanding of human brain evolution, suggesting that brain plasticity in humans is not due to being born less developed than other primates.

via SciTechDaily|

#brain-development #evolution #human-newborns

health2 years ago•2 min saved

"Caffeine's Impact on Brain Learning: Surprising Findings Unveiled"

Consuming high amounts of caffeine may hinder the brain's ability to rewire itself, according to a study analyzing brain signals associated with learning and memory. The study suggests that chronic caffeine use could limit learning and plasticity, challenging the assumption that caffeine promotes brain plasticity. The research, conducted on a small group of individuals, found that those who consumed fewer caffeinated drinks exhibited stronger effects of long-term potentiation (LTP), a process crucial for the brain to adapt and acquire new information. However, further well-controlled studies are needed to better understand the relationship between caffeine and its impact on learning and memory.

via ScienceAlert|

#brain #caffeine #health

health2 years ago•3 min saved

"Unlocking the Fountain of Youth: The Potential of a Protein to Reverse Brain Aging"

Researchers at Mount Sinai have discovered that the protein TIMP2 plays a crucial role in regulating brain plasticity, particularly in the hippocampus, a region important for memory and learning. Decreasing TIMP2 levels in mutant mouse models led to reduced plasticity and memory function. This finding could have implications for understanding and treating age-related disorders like Alzheimer's by targeting the brain's extracellular matrix. The study highlights the importance of studying pathways that regulate the extracellular matrix for designing novel therapies for diseases where plasticity is affected.

via SciTechDaily|

#alzheimers-disease #brain-aging #health

neuroscience3 years ago•5 min saved

Penn Medicine Study Reveals New Brain Development Sequence Through Adolescence

A new study from the University of Pennsylvania has found that brain development does not occur uniformly across the brain, but follows a newly identified developmental sequence. Brain regions that support cognitive, social, and emotional functions appear to remain malleable longer than other brain regions, rendering youth sensitive to socioeconomic environments through adolescence. The findings reveal that reductions in brain plasticity occur earliest in “sensory-motor” regions, such as visual and auditory regions, and occur later in “associative” regions, such as those involved in higher-order thinking (problem solving and social learning).

via Neuroscience News|

#adolescence #brain-development #mri

science3 years ago•3 min saved

Unusual Vaginal Abilities Found in Bomb-Sniffing Rats

Female giant African pouched rats, used for detecting landmines and tuberculosis, have the ability to open or close their vaginal entrance multiple times during their lifetime, even after giving birth. This unusual trait could have implications for breeding them more effectively and may even have broader implications for other mammals struggling to reproduce, including humans. The study's findings are a step toward understanding their reproductive biology and how traits once considered "fixed" in adult animals may become variable under specific pressures.

via SciTechDaily|

#landmines #plasticity #reproductive-biology

science3 years ago•2 min saved

The Fascinating Reproductive Habits of African Pouched Rats and Bomb Detector Rats

Female African pouched rats have been found to seal off their vaginas, preventing themselves from breeding. Researchers observed that some females had a smaller uterus and a fused vaginal opening, and their urine had a different chemical composition than their nestmates who were actively breeding. The phenomenon is speculated to be a result of one female manipulating others to stop reproducing, contributing to the care of the dominant reproducing female. This trait is unusual for mammals, and the hormones associated with breeding cycles in other rodents did not seem to determine which females were open for business in these giant African pouched rats.

via ScienceAlert|

#african-pouched-rats #hormones #olfactory-signals