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Sglt2 Inhibitors

All articles tagged with #sglt2 inhibitors

CKD in Diabetes: Diet, Meds, and Safer Bladder Treatments
health3 days ago

CKD in Diabetes: Diet, Meds, and Safer Bladder Treatments

Dr. Roach says CKD management hinges on solid diabetes care and lifestyle, not supplements: keep sodium under 2,000 mg daily, favor plant-based protein, and tightly control blood pressure with ACE inhibitors/ARBs (target ~130 mm Hg, possibly lower). Medications like finerenone may help when BP goals aren’t reached; SGLT2 inhibitors (e.g., empagliflozin) slow kidney decline, and GLP-1 drugs can offer heart/kidney protection with weight loss. An A1C goal of about 6.5–7.5% is typical but individualized. For bladder symptoms, long-term anticholinergics such as oxybutynin carry a small dementia risk; trospium has lower risk, and beta-3 agonists (mirabegron, vibegron) are often preferred when possible.

CKM Syndrome: The New Guideline Turns Heart, Kidney, and Metabolic Health Into a Single Risk Score
health10 days ago

CKM Syndrome: The New Guideline Turns Heart, Kidney, and Metabolic Health Into a Single Risk Score

The new CKM guideline officially unites heart, kidney, and metabolic health, introducing a stage system from 0 to 4, expanded screening with eGFR/UACR and a PREVENT risk calculator, and consideration of social factors like food stability. It also endorses GLP-1 and SGLT2 medications for eligible patients, emphasizing early lifestyle changes to reverse risk, so know your numbers and discuss your stage with your doctor.

Second-Line BP Drug May Harm Kidneys in Diabetics, Real-World Study Finds
health1 month ago

Second-Line BP Drug May Harm Kidneys in Diabetics, Real-World Study Finds

A real-world analysis of 31,031 adults with type 2 diabetes on RAS and SGLT2 inhibitors found that those also taking dihydropyridine calcium-channel blockers had a 33% higher risk of major kidney events (≥40% decline in eGFR or progression to dialysis/kidney transplant) over a median follow-up of 3.5 years. The observational study suggests potential kidney risk with this drug class even in patients on modern kidney-protective therapies, possibly due to how DCCBs affect intraglomerular pressure. Causation can’t be established; randomized trials are needed to guide BP management in diabetic kidney disease.

Tiny fish, big clue: diabetes drug slows kidney aging
science5 months ago

Tiny fish, big clue: diabetes drug slows kidney aging

Researchers used the ultra-fast-aging African turquoise killifish to model kidney aging and found that SGLT2 inhibitors slow age-related kidney damage by preserving capillaries, filtration barriers, energy metabolism, and reducing inflammation, helping explain the kidney and heart protection these drugs provide in humans and establishing the fish as a rapid aging model for testing therapies.

Diabetes Drug Shows Promise in Reducing Gout Medication Use
health1 year ago

Diabetes Drug Shows Promise in Reducing Gout Medication Use

New research indicates that sodium-glucose cotransporter-2 inhibitors (SGLT2i), a class of diabetes drugs, may reduce the need for urate-lowering therapy and gout flare treatments in patients with both type 2 diabetes and gout. The study, presented at the American College of Rheumatology 2024 Annual Meeting, found a 31% lower rate of initiation of urate-lowering therapy among SGLT2i users. While not yet altering standard gout management, these findings suggest potential benefits of SGLT2i as an adjunct therapy, possibly reducing the burden of polypharmacy and disease complications.

Promising Results in Phase III Trial of Novel Kidney Disease Drug
health2 years ago

Promising Results in Phase III Trial of Novel Kidney Disease Drug

An experimental drug, BI 690517, has shown significant benefits in reducing albuminuria, a sign of kidney damage, in patients with chronic kidney disease. When combined with a standard-care medication, 70% of participants experienced a significant reduction in albuminuria. The drug is designed to inhibit the production of aldosterone, a hormone that accelerates kidney disease progression. The trial also utilized an SGLT2 inhibitor, empagliflozin, which has shown kidney-protective effects. The findings will inform a Phase III clinical trial with 11,000 patient-participants worldwide, potentially revolutionizing the treatment of kidney disease.

"Promising Weight Loss Drugs Show Potential Cardiorenal Benefits in Kidney Disease Patients"
health2 years ago

"Promising Weight Loss Drugs Show Potential Cardiorenal Benefits in Kidney Disease Patients"

New weight loss drugs, such as glycogen-like peptide-1 receptor antagonists (GLP-1 RAs) and sodium glucose contransporter-2 (SGLT2) inhibitors, may have cardiorenal benefits for patients with chronic kidney disease (CKD), according to a nephrology specialist. These drugs have shown potential cardioprotective effects and metabolic improvements in patients with CKD, who often have obesity and metabolic syndrome. However, there is limited safety data for these drugs in CKD patients, and further research is needed to determine their efficacy and potential risks for advanced and end-stage CKD.

"New Guidelines Released for Chronic Coronary Disease by AHA/ACC"
healthcare2 years ago

"New Guidelines Released for Chronic Coronary Disease by AHA/ACC"

The American Heart Association (AHA) and the American College of Cardiology (ACC) have issued updated guidelines for managing patients with chronic coronary disease (CCD). The guidelines recommend changes in the use of beta-blockers, the inclusion of SGLT2 inhibitors and GLP-1 receptor agonists for select patients, and the use of statins as first-line therapy for lipid lowering. They also suggest shorter durations of dual antiplatelet therapy and discourage the use of nonprescription or dietary supplements. Revascularization is recommended in specific scenarios, and routine periodic testing is not recommended. The guidelines emphasize the importance of patient-centered care and shared decision-making.

Revolutionizing Type 2 Diabetes Care in Primary Settings.
healthcare3 years ago

Revolutionizing Type 2 Diabetes Care in Primary Settings.

Primary care providers (PCPs) manage over 75% of patients with type 2 diabetes (T2D) in the United States. Recent updates to the American Diabetes Association's Standards of Care in Diabetes guideline require PCPs to reframe approaches to diabetes pharmacotherapy and educate patients on the importance of managing cardiorenal and metabolic risk in addition to glucose levels. SGLT2 inhibitors and GLP-1 receptor agonists are recommended first-line medications for T2D patients with heart failure and chronic kidney disease. The new paradigm of diabetes management emphasizes cardiorenal risk reduction and weight management in addition to focusing on glucose control and the prevention and management of microvascular and macrovascular complications with non–glucose lowering agents.