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Clinical Research

All articles tagged with #clinical research

New study finds serious statin muscle side effects are exceptionally rare
health19 days ago

New study finds serious statin muscle side effects are exceptionally rare

A Lancet Digital Health study using health records from nearly 6 million UK adults shows the 10-year risk of serious statin-related muscle disorders (myopathy, myalgia, rhabdomyolysis) is about 0.04%, far lower than prior estimates. Most reported muscle symptoms are mild or due to other causes, and risk is influenced by factors like kidney disease, other medications, and vitamin D deficiency. Clinicians can personalize risk with new tools; statins remain highly beneficial for lowering LDL and reducing heart attack or stroke risk, and patients should discuss risks with their doctor rather than fear rare side effects.

America’s Comeback as the Global Leader in Medical Research
politics22 days ago

America’s Comeback as the Global Leader in Medical Research

RFK Jr. argues the U.S. must reclaim its lead in clinical trials and medical innovation, warning that China is ahead in early-stage testing and that Chinese firms accounted for nearly half of global pharma licensing deals in 2025. He outlines Trump-era reforms across FDA, NIH, ONC and ARPA-H to accelerate development while preserving safety, and calls for broad collaboration among researchers, health systems, tech companies and regulators to restore America’s competitive edge and patient access to new therapies.

Daily multivitamins linked to slower biological aging in seniors, study finds
health4 months ago

Daily multivitamins linked to slower biological aging in seniors, study finds

A Nature Medicine study of 958 older adults (average age 70) found that taking a daily Centrum Silver multivitamin–mineral for two years slowed biological aging by about four months across five epigenetic clocks; cocoa extract had no effect. Researchers caution that these early biomarker findings have not yet shown impacts on clinical outcomes and do not prove reduced disease risk.

Diabetes Drug Shows Promise in Reducing Gout Medication Use
health1 year ago

Diabetes Drug Shows Promise in Reducing Gout Medication Use

New research indicates that sodium-glucose cotransporter-2 inhibitors (SGLT2i), a class of diabetes drugs, may reduce the need for urate-lowering therapy and gout flare treatments in patients with both type 2 diabetes and gout. The study, presented at the American College of Rheumatology 2024 Annual Meeting, found a 31% lower rate of initiation of urate-lowering therapy among SGLT2i users. While not yet altering standard gout management, these findings suggest potential benefits of SGLT2i as an adjunct therapy, possibly reducing the burden of polypharmacy and disease complications.

"Unlocking the Secrets of Healthy Aging: Metformin's Genetic Influence"
health3 years ago

"Unlocking the Secrets of Healthy Aging: Metformin's Genetic Influence"

A study conducted by researchers from the University of Hong Kong suggests that metformin, a medication commonly used to treat type 2 diabetes, may promote healthy aging based on genetic evidence. The study, which analyzed data from over 300,000 participants, found that certain genetic variants related to metformin were associated with younger phenotypic age and longer leukocyte telomere length, both markers of healthy aging. These findings support further clinical research into the potential of metformin for promoting healthy longevity.

"Revolutionizing Genetics: A New Era of Ethnic Diversity-Informed Healthcare"
science-and-technology3 years ago

"Revolutionizing Genetics: A New Era of Ethnic Diversity-Informed Healthcare"

The Human Pangenome Reference Consortium has created a more inclusive human reference genome by assembling genomic sequences of 47 individuals from around the world, revealing almost 120 million DNA base pairs previously unseen. By providing a more accurate representation of human genetic diversity, researchers can refine their understanding of the link between genes and diseases, accelerate clinical research, and ultimately help address health disparities. The pangenome is public and can be used by scientists around the world as a new standard human genome reference. The HPRC’s ultimate goal is to produce high-quality, nearly error-free genomes from at least 350 individuals from diverse populations by mid-2024.