Tag

Single Cell Atlas

All articles tagged with #single cell atlas

science1 month ago•44 min saved

New Single-Cell Atlas Identifies Five Myeloma Archetypes and FCRL2 Target

Researchers published a large-scale single-cell atlas of multiple myeloma in Nature Genetics, identifying five distinct malignant transcriptional archetypes and a separate proliferative program. The study analyzed 341 individuals to link these biological states with genomic features, therapeutic resistance, and clinical outcomes. It also identified FCRL2 as a specific surface target on malignant plasma cells, which showed promise in CAR-T cell therapies.

via Nature|

#car-t #fcrl2 #multiple-myeloma

health6 months ago•69 min saved

Pregnancy-specific cell type found at maternal-fetal interface may regulate placental invasion

Live Science reports a Nature study that created a single-cell atlas of placental and uterine tissues from weeks 5–39 of pregnancy, analyzing about 1.2 million cells and identifying a previously undescribed pregnancy-only cell type, decidual stromal cell 4 (DSC4), at the maternal–fetal interface. DSC4 appears to help regulate fetal invasion into the uterus and arteries and carries cannabinoid receptors, a finding that could help explain cannabis-associated risks in pregnancy. By linking cell activity to genes tied to preeclampsia, preterm birth, and pregnancy loss, the atlas highlights which cells may drive complications and offers new targets for future research and therapies.

via Live Science|

#health #placenta #preeclampsia

science7 months ago•70 min saved

Skin’s cellular map reveals TNF-driven immune–fibroblast networks in SALT-like neighborhoods

Researchers generated an organ-wide, MERFISH-based single-cell spatial atlas of about 1.2 million cells from normal adult human skin, spanning 15 body sites and 22 donors, resolving 45 cell types and 10 multicellular neighborhoods. They highlight a perivascular neighborhood reminiscent of skin-associated lymphoid tissue (SALT) where TNF coordinates immune–fibroblast crosstalk, with CCL19+ fibroblasts proximal to vessels playing a central role. By integrating MERFISH with scRNA-seq and Visium data, they map site-specific cellular compositions, neighborhood dynamics, and ligand–receptor signaling, and show pan-disease immune alterations in the perivascular niche across skin conditions. An interactive web tool is provided to explore these data, underscoring spatial organization as a key driver of skin biology and disease.

via Nature|

#salt #science #single-cell-atlas

science7 months ago•7 min saved

Aging Decoded: 7-Million-Cell Atlas Maps Coordinated Decline Across 21 Organs

Researchers mapped nearly 7 million cells from 21 mouse organs at three ages to create the most detailed aging atlas yet, finding that aging proceeds in a synchronized, body-wide fashion with about a quarter of cell types changing in abundance and notable sex differences; the study also identified shared DNA-regulatory hotspots and cytokine-linked changes that could become targets for therapies aiming to slow aging across multiple organs.

via ScienceDaily|

#aging #anti-aging-therapy #epigenomics

health-and-science2 years ago•2 min saved

"Unveiling the Placental Microcosm: Single-Cell Atlas of Term Labor"

Researchers supported by the NIH have created a single-cell atlas of the placenta during term labor, offering insight into the communication between maternal and fetal cells during childbirth. The atlas, based on samples from 42 term pregnancies, reveals changes in gene expression patterns among different cell types and identifies cells most affected by labor in the chorioamniotic membranes. The study also suggests that placental biomarkers present in maternal blood may be used to identify pregnancies at risk for preterm birth, although further validation is needed.

via National Institutes of Health (.gov)|

#health-and-science #nih #placenta

science-and-technology2 years ago•3 min saved

Decoding the Intricacies of Human Limb Development: Unveiling Growth Processes and Birth Syndromes

Scientists have created the first human cell atlas of early limb development, revealing in exquisite detail how fingers and toes grow. By analyzing thousands of single cells from donated embryonic tissues, the researchers mapped gene expression patterns and identified distinct cell clusters involved in limb development. They found that the process is highly complex and precisely regulated, resembling a sculptor chiseling away at a block of marble. The study deepens our understanding of how anatomically complex structures form and has implications for research and healthcare. The researchers also showed that limb formation in humans and mice follows similar trajectories, with some differences in activated genes and cell types.

via ScienceAlert|

#embryonic-development #gene-expression #human-development