
Genetics May Reveal Who Benefits From Vitamin D to Prevent Diabetes
A genetic-subgroup analysis of the D2d trial found high-dose vitamin D (4,000 IU/day) lowered progression to type 2 diabetes only for adults with AC or CC variants of the vitamin D receptor gene; those with the AA variant did not benefit. Of 2,098 participants with genetic data, about 30% had AA. This suggests a path toward personalized prevention for the roughly 115 million Americans with prediabetes, but healthcare guidance remains to avoid high-dose vitamin D without medical advice due to safety concerns and the need for more research.












