Tag

Endometrial Cancer

All articles tagged with #endometrial cancer

health28 days ago•7 min saved

GLP-1 Weight-Loss Drugs Linked to Strong Reductions in Obesity-Related Cancer Risk

A large observational study of over 229,000 obese, non-diabetic adults found GLP-1 receptor agonists (including semaglutide and tirzepatide) associated with a 41% lower overall risk of obesity-related cancers, with especially large reductions for endometrial cancer (about 58%), and notable drops for pancreatic and colorectal cancers; the study cannot prove causation and longer-term research is needed to confirm these findings.

via Medical News Today|

#cancer #colorectal-cancer #endometrial-cancer

healthcare1 month ago•23 min saved

Merck’s Sac-TMT Phase 3 Trial Hits Dual Endpoints in Endometrial Cancer

Merck announced TroFuse-005, a global Phase 3 trial, met its dual primary endpoints of overall survival and progression-free survival for sacituzumab tirumotecan (sac-TMT) versus physician’s choice chemotherapy in advanced or recurrent endometrial cancer after platinum-based therapy and anti‑PD-1/L1 therapy; interim analysis showed statistically significant OS and PFS improvements and a positive objective response rate, with a safety profile consistent with prior studies. The TroFuse program spans 17 global Phase 3 trials across multiple tumor types, highlighting Merck’s leadership in TROP2-directed ADCs in women’s cancers.

via Merck.com|

#endometrial-cancer #healthcare #phase-3

clinical2 months ago•9 min saved

ACOG Advances PMB Evaluation with Combined Ultrasound and Tissue Sampling

ACOG released a Clinical Practice Update advising that most patients with postmenopausal bleeding should be evaluated with a combination of transvaginal ultrasound and endometrial tissue sampling at the initial visit to improve early detection of endometrial cancer, reduce missed diagnoses, and address disparities—emphasizing shared decision making and patient-centered counseling.

via ACOG|

#clinical #clinical-practice-update #endometrial-cancer

health5 months ago•7 min saved

Could ibuprofen lower some cancer risks? Early findings with caveats

Emerging studies link regular ibuprofen use with lower risks of endometrial and bowel (colorectal) cancers, possibly by dampening inflammation and affecting cancer-related genes, though evidence is not conclusive and high-dose or long-term NSAID use can cause serious side effects. Experts caution against self-prescribing ibuprofen for cancer prevention and emphasize proven prevention strategies like a healthy weight, exercise, and a balanced diet.

via ScienceDaily|

#cancer-risk #endometrial-cancer #health

health5 months ago•8 min saved

Ibuprofen and Cancer Risk: Early Signals, Cautious Outlook

New research links ibuprofen’s anti-inflammatory action to possible cancer-risk modulation, including a potential lower risk of endometrial cancer and hints of protection against other cancers, but the evidence is mixed and experts warn against using ibuprofen for cancer prevention due to side effects and drug interactions; maintaining a healthy lifestyle remains the best prevention strategy.

via SciTechDaily|

#cancer #endometrial-cancer #health

health9 months ago•3 min saved

Researchers Warn of New Reproductive Health Threats from Environmental and Biological Factors

New research indicates that microplastic particles are present in all examined endometrial tissues and are significantly higher in cancerous tissues, potentially disrupting metabolic pathways and contributing to the development of endometrial cancer, raising concerns about the broader impact of plastic pollution on women's reproductive health.

via yahoo.com|

#endometrial-cancer #health #microplastics

health9 months ago•2 min saved

Visceral Fat Activity Linked to Aggressive Endometrial Cancer in Women

A new study links metabolically active visceral fat around internal organs to more aggressive endometrial cancer in women, suggesting that the activity level of belly fat, not just its amount, influences cancer severity and could lead to new diagnostic and treatment strategies.

via Times of India|

#cancer #endometrial-cancer #health

health11 months ago•3 min saved

5 Hidden Signs of Endometrial Cancer Doctors Warn About

Endometrial cancer often presents with subtle signs such as unusual vaginal bleeding, abnormal discharge, constant pelvic pain, changes in bathroom habits, and unexplained weight loss. Recognizing these symptoms early and consulting a doctor is crucial for timely diagnosis and treatment, especially since there is no screening test for this cancer.

via Prevention|

#early-detection #endometrial-cancer #health

health1 year ago•7 min saved

NC Woman Shares Endometrial Cancer Battle at 32 to Raise Awareness

Wendy Maultsby, diagnosed with endometrial cancer at 32, highlights the rising trend of younger women being affected by this typically older-age cancer, emphasizing the importance of awareness, early detection, and research, especially among at-risk groups.

via WRAL.com|

#cancer-awareness #early-detection #endometrial-cancer

medical-research2 years ago•34 min saved

Advancements in Urine-Based Testing and Treatments Show Promise for Bladder Cancer Survival

A study published in BMC Women's Health utilized urine metabolomics to assess the efficacy of fertility-sparing treatment in endometrial cancer (EC) patients. The researchers analyzed urine samples using ultra-performance liquid chromatography mass spectrometry (UPLC-MS) and identified distinct metabolites and altered metabolic pathways. They developed a panel of biomarkers that demonstrated high predictive ability in identifying patients with complete remission (CR). The panel consisted of Baicalin, 5beta-1,3,7 (11)-Eudesmatrien-8-one, Indolylacryloylglycine, Edulitine, and Physapubenolide. This non-invasive approach offers a less invasive means of monitoring treatment efficacy and may aid in evaluating fertility-sparing treatments for EC patients. Further research is needed to validate the biomarker panel in larger populations.

via BioMed Central|

#biomarkers #endometrial-cancer #fertility-sparing-treatment

healthcare2 years ago•0 min saved

GSK's Checkpoint Inhibitor and Chemotherapy Combo Improves Survival in Endometrial Cancer

GSK's checkpoint inhibitor, Jemperli, when added to chemotherapy, has been found to prolong the survival of patients with advanced or recurrent endometrial cancer in a Phase III study. The study met its primary overall survival endpoint, with patients receiving Jemperli-chemo treatment living longer than those in the comparator arm.

via Endpoints News|

#checkpoint-inhibitor #chemotherapy #clinical-trial

health3 years ago•3 min saved

New drug combination shows promise in treating advanced endometrial cancer.

Two studies published in the New England Journal of Medicine found that adding immunotherapy drug pembrolizumab to the standard chemotherapy regimen of carboplatin and paclitaxel reduced the risk that patients' advanced or recurrent endometrial cancer would return by up to 70%. The impact was more dramatic in women with a mismatch repair-deficient tumor, a specific type of endometrial cancer. The Food and Drug Administration would need to amend its guidance on using immunotherapy in this way before it's widely implemented as the protocol for treating late-stage endometrial cancer.

via NBC News|

#chemotherapy #dostarlimab #endometrial-cancer