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Jennifer Doudna

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Doudna’s AI-designed tiny nucleases promise on-demand gene editing
science3 days ago

Doudna’s AI-designed tiny nucleases promise on-demand gene editing

Nobel laureate Jennifer Doudna and colleagues report an AI-driven platform for designing non-natural nucleases, producing a tiny TnpB enzyme capable of binding and cutting DNA in human, plant, and bacterial cells. By using an inverse protein-model to tailor sequences to predefined backbones, the team envisions on-demand enzyme design with potential medical and agricultural applications and notes possible IP implications as the field advances.

via Fierce Biotech|
#artificial-intelligence#gene-editing#jennifer-doudna
CRISPR’s Next Act: From Bacterial Defense to One-Time Therapies and Global Ethics
science1 month ago

CRISPR’s Next Act: From Bacterial Defense to One-Time Therapies and Global Ethics

Jennifer Doudna describes how CRISPR-Cas9 evolved from a bacterial immune system into a programmable gene-editing tool, its rapid uptake across medicine and agriculture, and the ongoing delivery challenges to different tissues. The discussion covers a landmark 2024 liver-targeted therapy for Baby KJ, the prospect of one-time genetic treatments, and the ethical, regulatory, and accessibility questions raised by germline edits (notably the 2018 case), underscoring the need for cautious public engagement as the CRISPR toolbox expands.

via Quanta Magazine|
#crispr#delivery#ethics
"Unlocking the Potential: Jennifer Doudna's Insights on Gene Editing"
science-and-technology2 years ago

"Unlocking the Potential: Jennifer Doudna's Insights on Gene Editing"

Nobel laureate Jennifer Doudna, a pioneer of CRISPR-Cas9 gene editing, emphasizes the need for more efficient and affordable delivery methods for CRISPR-based therapies, following the recent FDA approval of a sickle-cell therapy. The current process, involving bone marrow extraction and genetic engineering, is physically challenging and costly, limiting its widespread use. Doudna advocates for in vivo genome editing to address this bottleneck, highlighting ongoing efforts to develop nanoparticle delivery systems. She remains confident that solving the delivery challenge will unlock the immense potential of gene editing to alleviate human suffering.

via Harvard Gazette|
#crispr#gene-editing#harvard-medical-school
"Trailblazing Women: Unveiling a World-Changing Scientific Breakthrough"
science-and-technology2 years ago

"Trailblazing Women: Unveiling a World-Changing Scientific Breakthrough"

"SaveGood Chemistry" is a documentary highlighting the work of Emmanuelle Charpentier and Jennifer Doudna, the first all-female team to win the Nobel Prize for chemistry in 2020 for their groundbreaking CRISPR gene-editing discovery. The film delves into the years of experimentation and collaboration that led to their landmark 2012 paper on the CRISPR system, offering insight into the biochemistry behind CRISPR and the experience of contributing to a world-changing scientific breakthrough.

via Aeon|
#crispr#emmanuelle-charpentier#gene-editing
"Advancing Targeted Gene Editing: CRISPR Delivery Breakthroughs"
science-and-technology2 years ago

"Advancing Targeted Gene Editing: CRISPR Delivery Breakthroughs"

Scientists have developed enveloped delivery vehicles (EDVs) that can transport CRISPR genome editing tools to specific cells for precise genome engineering within living organisms. These EDVs, created by Nobel Prize winner Jennifer Doudna's lab, have the potential for widespread therapeutic use and were shown to successfully target and edit the genomes of human cells in both in vitro and in vivo experiments. The research establishes a programmable delivery method for genome editing and highlights the potential for targeted in vivo engineering of tissue-resident stem cells.

via Genetic Engineering & Biotechnology News|
#crispr#genome-editing#in-vivo-engineering