Tag

Nejm

All articles tagged with #nejm

politics11 days ago•16 min saved

Cruz's 82% miscarriage claim about COVID vaccines debunked by experts

Sen. Ted Cruz amplified a debunked claim that the second COVID-19 vaccine dose carries an 82% miscarriage risk for women in the first trimester. Health experts and major medical groups say there is no increased miscarriage risk from vaccination during pregnancy, and the 82% figure stems from a misinterpretation of NEJM data. CDC follow-up analyses show miscarriage rates among vaccinated pregnant people are within the expected range, while organizations like ACOG continue to endorse vaccination during pregnancy. Cruz has faced backlash for repeating this misinformation.

via HuffPost|

#covidvaccine #misinformation #nejm

health1 month ago•4 min saved

MenB vaccine falls short against gonorrhoea, study finds

An Australian GoGoVax trial with 587 men over two years found no difference in gonorrhoea infections between those who received the MenB vaccine and those who received a placebo, indicating the vaccine does not protect against gonorrhoea; UK Health Security Agency says they will wait for more robust data before changing vaccination policy.

via BBC|

#gogovax #gonorrhoea #health

health2 months ago•7 min saved

Finerenone Extends Kidney Disease Benefits to Non-Diabetic Patients

A NEJM-identified FIND-CKD trial shows finerenone, previously used for diabetic CKD, also slows kidney function decline in adults with CKD who do not have diabetes. In 1,584 non-diabetic participants, finerenone added to standard therapy (ACE inhibitors/ARBs) significantly slowed eGFR loss over about 2.5 years and reduced the risk of major kidney events, heart failure hospitalization, and cardiovascular death by roughly 23%, while also lowering urinary protein by over 40%. The drug was well tolerated, suggesting it could broaden treatment to the roughly 800 million non-diabetic CKD patients worldwide.

via SciTechDaily|

#chronic-kidney-disease #find-ckd #finerenone

science3 months ago•1 min saved

AAV Gene Therapy Linked to Brain Tumor in Hurler Syndrome Case

A NEJM case report documents a young Hurler syndrome patient who received adeno-associated virus–delivered gene therapy and later developed a walnut-sized brain tumor believed to be caused by an unintended gene mutation; the tumor was removed, cognitive development progressed, highlighting rare but serious risks associated with gene therapies.

via Futurism|

#aav #brain-tumor #gene-therapy

health3 months ago•58 min saved

Antiviral pill cuts COVID risk after exposure, NEJM trial finds

A five‑day course of ensitrelvir (Xocova) significantly reduced the risk of developing COVID-19 after household exposure in a double‑blind NEJM phase 3 trial of about 2,000 participants: 9% in the placebo group developed symptoms within 72 hours versus 2.9% in the drug group; by day 10, 14% vs 21.5% tested positive. Side effects were similar between groups. The drug is already approved in Japan for treatment and is being considered for post‑exposure prevention by US/EU regulators; pregnancy safety was not studied.

via Live Science|

#antiviral #covid-19 #ensitrelvir

health3 months ago•4 min saved

Paxlovid speeds up recovery but doesn’t cut hospitalizations for the vaccinated, NEJM study finds

A New England Journal of Medicine analysis of Canadian and UK trials (about 4,200 participants) found Paxlovid does not reduce hospitalizations or death in a largely vaccinated population, though users recovered about three days faster; the results could influence how public funding and prescriptions are targeted for antivirals.

via CTV News|

#clinical-trial #covid-19 #health

science5 months ago•4 min saved

Ice-Age Mother-Daughter Skeletons Reveal Earliest AMDM Case

Ancient DNA analysis of two closely related Ice Age skeletons from Romito Cave in Italy identifies a mother–daughter pair, with the younger diagnosed with acromesomelic dysplasia, Maroteaux type (AMDM) caused by NPR2 mutations—the earliest known AMDM case. The study highlights how a family carried a gene variant affecting bone growth and shows care within the group; findings were published in The New England Journal of Medicine.

via ScienceAlert|

#acromesomelic-dysplasia-maroteaux #ancientdna #nejm

health6 months ago•2 min saved

One-pivotal-trial rule aims to redefine drug approvals

FDA officials say a single pivotal trial will be the default standard for drug approvals, a policy shift outlined in an NEJM perspective by Marty Makary and Vinay Prasad.

via Endpoints News|

#drug-approvals #fda #health

science-and-medicine10 months ago•3 min saved

NEJM Launches MMWR Rival Amidst Scientific and Ethical Concerns

The article summarizes recent developments in scientific publishing, including NEJM launching a new public health report rival, a former NIH official's paper receiving an expression of concern, and a study revealing that 1 in 5 chemists have intentionally added errors during peer review, highlighting ongoing issues of misconduct and integrity in research.

via Retraction Watch|

#academic-publishing #nejm #research-integrity

public-health10 months ago•3 min saved

NEJM and Public Health Group Launch Rival to CDC's MMWR

The NEJM and CIDRAP are launching a new, free publication of public health alerts as an alternative to the CDC's MMWR, aiming to improve timely dissemination of outbreak data amid declining trust and operational challenges faced by the CDC's traditional publication.

via statnews.com|

#cdc #cidrap #mmwr

health-and-science2 years ago•5 min saved

"NIH's Policy Evolution: Embracing Open Science and Transforming Clinical Research"

The National Institutes of Health (NIH) has implemented a new data sharing policy to increase transparency in biomedical research, a move praised in a recent New England Journal of Medicine (NEJM) op-ed. This policy shift marks a significant reversal from NEJM's previous stance, which had controversially criticized data sharing by coining the term "research parasites." The change reflects the growing Open Science movement, advocating for public access to data from government-funded research to accelerate scientific progress. The NEJM now supports the idea of a government repository for scientific data to ensure compliance with sharing policies and facilitate broader research collaboration.

via Forbes|

##datasharing #health-and-science