Tag

Oral Medication

All articles tagged with #oral medication

health4 days ago•5 min saved

Personal Trial: An Endocrinologist Takes an Oral GLP-1 to Potentially Prevent Dementia

An endocrinologist shares a personal choice to start orforglipron, an oral GLP-1, at age 48 to potentially reduce dementia risk after watching her mother’s Alzheimer’s progression. She notes no proven dementia prevention data yet, but cites brain-related mechanisms, observational signals of lower dementia rates with GLP-1s, and mixed trial results. The decision is deeply personal, balancing evolving science with family history and broader health goals, while continuing other healthy aging practices.

via Medscape|

#alzheimers-disease #dementia-prevention #glp-1-receptor-agonists

health3 months ago•6 min saved

New Oral GLP-1 Pill Shifts the Weight-Loss Race Against Ozempic

A 52-week phase-3 trial in 1,698 adults with type 2 diabetes across six countries found orforglipron, a daily oral small-molecule GLP-1 drug, reduced HbA1c more and produced greater weight loss than oral semaglutide (1.71–1.91% vs 1.47% HbA1c and 6.1–8.2 kg vs 5.3 kg), but caused more gastrointestinal side effects and higher discontinuation (~10% vs 4–5%). It’s cheaper to manufacture and doesn’t require refrigeration, giving it logistical advantages, though long-term comparisons with injectable GLP-1 therapies and obesity trials without diabetes are still underway.

via ScienceAlert|

#diabetes #glp-1 #health

health10 months ago•3 min saved

Novo Nordisk's Oral Semaglutide Shows Promise for Weight Loss

A clinical trial shows that an oral form of semaglutide, a drug used for weight loss and diabetes management, is effective in significantly reducing body weight, offering a less invasive alternative to injections. The study involved 205 participants and found an average weight loss of 13.6%, with manageable side effects, paving the way for potential regulatory approval of oral Ozempic.

via ScienceAlert|

#clinical-trial #health #oral-medication

health-and-wellness10 months ago•3 min saved

Wegovy Pill Shows Promising Weight Loss Results in Trials

A clinical trial shows that an oral form of Wegovy is as effective as the injectable version in promoting weight loss, with patients losing around 16.6% of their body weight over 64 weeks, fueling optimism for expanding weight-loss treatments. Both Novo Nordisk and Eli Lilly are racing to bring their oral obesity drugs to market, with promising trial results and plans for FDA approval, despite side effects and adherence challenges.

via The Washington Post|

#clinical-trial #health-and-wellness #novo-nordisk

health10 months ago•4 min saved

Lilly's New GLP-1 Pill Outperforms Competitors in Weight Loss and Diabetes Trials

A new oral GLP-1 agonist, orforglipron, has shown promising results in a large trial, helping obese patients lose up to 11% of their body weight over 72 weeks, offering a potentially more accessible alternative to injectable treatments, with significant improvements in cardiometabolic health markers.

via SciTechDaily|

#glp-1 #health #obesity

health3 years ago•6 min saved

Oral GLP-1 Agonists: The Future of Weight Loss and Diabetes Treatment

Eli Lilly's investigational oral daily nonpeptide GLP-1 agonist, Orforglipron, appears comparable with other injectable and oral agents in the class for treating obesity and type 2 diabetes, according to two new phase 2 studies. Orforglipron is a small molecule that isn't a peptide, so it isn't degraded in the gastrointestinal tract, making it more convenient for patients to take. The drug showed promising results in reducing body weight and A1c levels in patients with obesity and type 2 diabetes, respectively, and could potentially improve access to care for people with obesity who don't have the means to afford effective treatments.

via Medscape|

#clinical-trials #glp-1-agonist #health

health3 years ago•3 min saved

Oral Insulin Made from Lettuce: A Game-Changer in Diabetes Treatment

Researchers at the University of Pennsylvania have developed a way to harvest insulin grown in lettuce, which can be taken orally and doesn't require painful injections. The plant-based insulin is cheaper, easier to distribute, and contains the missing C-peptide found in natural insulin, making it a better substitute for the real kind. The insulin is protected by the tough plant cell walls, allowing it to travel to the gut and eventually reach the liver. The next step is to trial the plant-based insulin in dogs and then people, potentially making insulin more affordable and accessible for the half a billion people with diabetes worldwide.

via Freethink|

#diabetes #health #insulin