Tag

Orexin

All articles tagged with #orexin

business11 days ago•12 min saved

Lilly to acquire Centessa to accelerate orexin-based sleep-wake therapies

Eli Lilly will acquire Centessa Pharmaceuticals for up to $47 per Centessa share (cash of $38 plus a non-transferable contingent value right) in a deal valued at about $6.3 billion upfront with up to $1.5 billion more via CVR milestones, expanding Lilly’s neuroscience portfolio into sleep medicine. Centessa’s lead orexin receptor 2 (OX2R) agonist program, led by cleminorexton (formerly ORX750), targets narcolepsy types 1 and 2 and idiopathic hypersomnia and is supported by additional assets across neurological indications. The transaction is subject to Centessa shareholder and regulatory approvals and is expected to close in Q3 2026.

via Eli Lilly|

#business #centessa #lilly

health10 months ago•8 min saved

Sleep Aids and Their Potential Role in Alzheimer’s Prevention

A study in Nature Neuroscience found that lemborexant, a sleep medication, can reduce brain inflammation and tau protein buildup in a mouse model of Alzheimer's, suggesting that targeting sleep-wake systems might help prevent or slow neurodegenerative diseases. The drug improved sleep patterns, decreased tau pathology, and protected brain structure, especially in male mice, highlighting potential for repurposing sleep drugs as disease-modifying therapies. However, further research is needed to confirm these effects in humans and understand sex differences.

via PsyPost|

#alzheimers #health #neurodegeneration

neuroscience2 years ago•6 min saved

Orexin's Influence on Pupil Size Revealed

Orexin, not the stress hormone noradrenaline, is responsible for regulating pupil size, challenging previous understanding. Orexin neurons affect pupil size in response to emotional states and mental strain, not just light exposure. This discovery has implications for neurological conditions such as narcolepsy and Alzheimer's, offering new diagnostic avenues. It also sheds light on our understanding of consciousness and attention regulation.

via Neuroscience News|

#consciousness-regulation #neurological-conditions #neuroscience