Tag

Piezo1

All articles tagged with #piezo1

science7 days ago•5 min saved

Shinbone Compression Triggers Brain Repair via Blood-Borne Signals

Researchers at Southern Medical University in China found that applying rhythmic pressure to the shinbone of mice and pigs with brain injuries significantly improved survival and neurological recovery. The study, published in Nature Neuroscience, demonstrates a bidirectional 'bone-brain axis' where mechanical stimulation of bone cells releases protective chemicals into the bloodstream that reduce inflammation and promote neuron repair in the brain.

via ScienceAlert|

#bone-biology #neuroscience #osteocytes

science7 days ago

Shin Tapping May Heal Brain Injuries via Bone Protein Signal

Researchers at Southern Medical University discovered that rhythmic tapping on the shin bones of mice and pigs with brain injuries can accelerate neural recovery. The study, published in Nature Neuroscience, shows that this mechanical stimulation reduces cell loss, promotes neuron growth, and improves motor function. The healing effect relies on the PIEZO1 protein in bone cells, which opens ion channels in response to pressure, sending signals to the brain. Animals lacking this protein showed no benefits, confirming the bone-to-brain communication pathway.

via Nautilus | Science Connected|

#bone-biology #neuroscience #piezo1

science7 months ago•7 min saved

Brain wiring revealed: tissue stiffness steers neural signals through Piezo1

New findings show brain tissue stiffness triggers production of chemical guidance cues via the mechanosensitive Piezo1, linking mechanical forces to neuronal wiring; Piezo1 also helps maintain tissue structure by regulating cell adhesion proteins, suggesting mechanical cues actively shape brain development and may influence disease.

via ScienceDaily|

#axon-guidance #brain-development #mechanical-signaling

science7 months ago•4 min saved

Piezo1 Identified as Exercise Sensor Linking Movement to Bone Strength

Scientists at the University of Hong Kong identify Piezo1 as an exercise-sensing protein in bone marrow stem cells that shifts fate toward bone-forming osteoblasts and away from fat cells; mice lacking Piezo1 show weaker bones and reduced exercise benefits, while activating its pathway could mimic exercise to combat osteoporosis—though findings are preclinical and demand cautious development for human therapies.

via ScienceAlert|

#bone-marrow-mesenchymal-stem-cells #exercise #osteoblasts

health8 months ago•8 min saved

Piezo1: the bone exercise sensor that could shield bones without movement

Researchers have identified Piezo1 on bone marrow mesenchymal stem cells as the body’s mechanical sensor that links physical activity to reduced marrow fat and new bone formation; activating this pathway could yield drugs that mimic exercise to slow osteoporosis for patients who cannot move.

via ScienceDaily|

#bone-marrow-adipogenesis #exercise-mimetics #health

science8 months ago•4 min saved

Lipid brake on brain blood flow opens new path for dementia therapy

Researchers found that PIP2 acts as a brake on Piezo1, a pressure sensor in brain vessels. In Alzheimer’s-model mice, low PIP2 led to Piezo1 overactivation and disrupted brain blood flow, but restoring PIP2 largely normalized flow, suggesting a potential new therapeutic target for dementia—though findings are early and based on mouse studies.

via ScienceAlert|

#alzheimers-disease #cerebral-blood-flow #dementia

health8 months ago•5 min saved

New Bone Discovery Paves Way for Exercise-Free Osteoporosis Treatment

Scientists from HKUMed discovered that the Piezo1 protein acts as an 'exercise sensor' in bones, translating physical activity into signals that strengthen bones and reduce fat accumulation in bone marrow. This breakthrough could lead to the development of drugs that mimic exercise effects, offering new treatments for osteoporosis, especially for those unable to exercise.

via SciTechDaily|

#bone-health #drug-development #exercise-sensor

health9 months ago•3 min saved

New Brain Discovery Offers Hope for Dementia Treatment

Scientists at the University of Vermont have discovered that increasing levels of the phospholipid PIP2 in brain cell membranes may help regulate blood flow in the brain by inhibiting the Piezo1 protein, potentially offering a new approach to treat dementia and related neurovascular diseases.

via SciTechDaily|

#brain-blood-flow #dementia #health

health9 months ago•2 min saved

Restoring Brain Blood Flow and Phospholipids as Potential Treatments for Vascular Dementia

Scientists at the University of Vermont have discovered that restoring levels of the phospholipid PIP2 can reduce overactivity of the Piezo1 protein in brain blood vessels, potentially improving blood flow and alleviating symptoms of dementia, offering a promising new avenue for treatment.

via ScienceDaily|

#brain-blood-flow #dementia #health

science11 months ago•2 min saved

Human Hybrids Could Explain Neanderthal Extinction

A new study suggests that interbreeding between Neanderthals and Homo sapiens introduced a gene variant in Neanderthals that may have caused reproductive issues, potentially contributing to their eventual extinction by creating a genetic mismatch that reduced their survival over generations.

via IFLScience|

#extinction #genetics #homo-sapiens

science-and-technology3 years ago•4 min saved

"Groundbreaking Footage: Nobel-winning 'Pressure Sensors' Capture Microscopic Pressure Changes"

Researchers at Imperial College London have successfully filmed the activity of Piezo1 and Piezo2, bodily "pressure sensors" that won the 2021 Nobel Prize in Physiology or Medicine. These ion channels are found throughout the body and play a crucial role in regulating blood pressure, respiration, bladder control, and the immune system. By developing a specific biosensor called GenEPi, the researchers were able to visualize the activity of Piezo1 channels in various cells and organisms. This non-invasive method could lead to new drug targets for diseases such as cancer and provide insights into fundamental physiological processes.

via Phys.org|

#drug-targets #nobel-prize #physiological-processes