Ancient Mammalian Peptides Show Superior Bacteria-Killing Power Over Modern Antibiotics
University of Oregon researchers reconstructed antimicrobial peptides from mammalian ancestors dating back 160 million years, finding that some ancient versions kill drug-resistant bacteria more effectively than modern human counterparts. The study, published in PLOS Biology, suggests that minor evolutionary mutations significantly enhanced these proteins' ability to puncture bacterial membranes. While these peptides offer a potential alternative to failing antibiotics, they remain unstable in the human body, requiring further engineering for therapeutic use.













