Two APOE-e4 copies spark a brain-health overhaul
Elena Castellanos, who learned she carries two copies of the APOE e4 Alzheimer’s risk gene, has begun a proactive brain-health program with preventive neurologist Dr. Kellyann Niotis. She’s adopting a Mediterranean diet, increasing omega-3 intake, and combining strength training, HIIT, and cardio; improving sleep (including managing sleep apnea) and cutting alcohol; and keeping up with regular medical and biomarker testing. In just one year, her brain-inflammation marker GFAP dropped ~32%, amyloid declined ~20%, and tau dropped ~29%, with cholesterol and muscle gains as additional wins. While tests can be costly, Castellanos hopes these lifestyle changes can reduce her risk, underscoring that genetics aren’t destiny and that informed choices can matter for brain health.
