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Nasal Spray

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Antihistamine Nasal Spray May Lower COVID Risk, New Study Finds
health27 days ago

Antihistamine Nasal Spray May Lower COVID Risk, New Study Finds

A phase 2 JAMA trial with 450 vaccinated adults in Germany found that using azelastine nasal spray (3–5 times daily for ~56 days) reduced COVID-19 infection risk to 2.2% vs 6.7% for placebo, shortened illness duration (3.4 vs 5.14 days), and lowered overall viral infections (8.4% vs 18.8%). Side effects were usually mild (e.g., bitter taste, nosebleeds, fatigue). Experts say it could be complementary to vaccines but not a substitute, and more research is needed before recommending it as a preventive measure.

via Prevention|
#azelastine#covid-19#health
Nine science-backed tips to beat pollen season
health29 days ago

Nine science-backed tips to beat pollen season

A BBC guide outlines nine science-based strategies to reduce hay fever symptoms: use nasal corticosteroid or combined sprays (not pills) as first-line treatment, avoid prolonged use of nasal decongestants, if using pills choose second-generation antihistamines, start treatment weeks before pollen season and take it regularly and correctly, ensure proper nasal-eye drop technique, reduce exposure to triggers (keep windows closed, wear sunglasses or a mask, shower after outdoors), and seek medical help if symptoms persist (allergen immunotherapy may offer longer-term relief).

via BBC|
#allergies#antihistamines#hay-fever
Experts name the OTC allergy meds that truly relieve spring symptoms
health1 month ago

Experts name the OTC allergy meds that truly relieve spring symptoms

Allergists say several OTC meds—particularly second-generation antihistamines like Zyrtec, Allegra, and Claritin, plus nasal steroids like Flonase—provide strong relief for runny noses, watery eyes, and sneezing, and can be as effective as prescription options. They caution that the best choice depends on symptoms and health conditions, including kids (Claritin Children’s Chewables). Start with a consult with a doctor or pharmacist to tailor your plan, and be aware that pollen counts are higher and springs are starting earlier due to climate change, so consider starting treatment earlier in the season.

via AOL.com|
#allergy#antihistamines#health
Two-Dose Nasal Spray Reverses Brain Aging in Weeks, Texas A&M Finds
science1 month ago

Two-Dose Nasal Spray Reverses Brain Aging in Weeks, Texas A&M Finds

Texas A&M researchers report a two-dose nasal spray that uses microRNA-loaded extracellular vesicles to bypass the blood-brain barrier, reduce neuroinflammation, and restore cognitive function in aging animal models within weeks — with effects lasting months and observed in both sexes. Human trials are years away; the team has filed a patent and has backing from the National Institute on Aging, though safety details remain undisclosed.

via Yahoo|
#brain-aging#extracellular-vesicles#microrna
Nasal spray reverses brain aging markers in mice, study finds
science1 month ago

Nasal spray reverses brain aging markers in mice, study finds

A preclinical mouse study reports a nasal spray that delivers extracellular vesicles containing microRNAs to the brain can reverse signs of brain ageing within weeks, lowering inflammation and boosting cognitive processing. Two doses showed benefits, suggesting the brain’s repair systems can be reactivated, but more research and human trials are needed.

via HuffPost UK|
#brain-aging#extracellular-vesicles#micrornas
Researchers chase a universal respiratory vaccine, but it's still years away
health1 month ago

Researchers chase a universal respiratory vaccine, but it's still years away

A nasal-spray vaccine tested in mice stimulates the lungs’ innate immune system to mount broad protection against multiple respiratory pathogens, including viruses, bacteria and even allergens. While the approach shows proof-of-concept for wider protection, experts caution it is far from a universal vaccine for humans and will require extensive clinical trials to assess safety, durability and effectiveness across diverse populations.

via Live Science|
#health#innate-immunity#nasal-spray
Nasal universal vaccine shields mice from viruses, bacteria, and allergies
science2 months ago

Nasal universal vaccine shields mice from viruses, bacteria, and allergies

A nasal spray vaccine, GLA-3M-052-LS+OVA, protected mice against SARS-CoV-2 and other coronaviruses, guarded against certain bacteria, and reduced allergy-related lung symptoms, by engaging both innate and adaptive immunity; with three doses, it lowered lung viral loads and sped up immune responses, and human trials could begin with a target availability in 5–7 years if results translate to people.

via ScienceAlert|
#adaptive-immunity#innate-immunity#nasal-spray
Nasal universal vaccine shows cross-protection against cold, flu, and COVID in mice
science3 months ago

Nasal universal vaccine shows cross-protection against cold, flu, and COVID in mice

A nasal vaccine candidate that trains frontline lung immunity shows promise in mice for broad protection against multiple respiratory infections (cold viruses, flu, and COVID) by boosting alveolar macrophages and T cells rather than targeting a single pathogen; it may also dampen allergic reactions. Human safety and efficacy remain unproven, and the best-case path to a human-ready vaccine is five to seven years, with protection in mice lasting up to about three months and many unknowns, including effects in older adults and on DNA viruses.

via The Conversation|
#alveolar-macrophages#mucosal-immunity#nasal-spray
Researchers Unveil Universal Nasal Spray Vaccine Targeting Viruses, Bacteria, and Allergens
health-and-medicine3 months ago

Researchers Unveil Universal Nasal Spray Vaccine Targeting Viruses, Bacteria, and Allergens

Stanford Medicine researchers have developed a nasal spray vaccine that activates the lungs’ innate immune system to provide months-long protection against a broad range of respiratory threats—including SARS-CoV-2, other coronaviruses, bacterial pneumonia pathogens, and even house dust mite allergens—in mice. If safety and efficacy are shown in humans, the approach could reduce the need for multiple yearly vaccines and idea of rapid protection during outbreaks, with Phase I trials moving forward and an estimated 5–7 years before potential availability.

via ScienceDaily|
#health-and-medicine#innate-immunity#nasal-spray
Nationwide Recall of Nasal Spray Over Mold, Yeast, and Microbial Contamination Risks
health5 months ago

Nationwide Recall of Nasal Spray Over Mold, Yeast, and Microbial Contamination Risks

A nationwide recall has been issued for ReBoost Nasal Spray due to contamination with yeast, mold, and microbes, posing health risks especially to immunocompromised individuals. Consumers are advised to stop using the product and return it for a refund, and those experiencing symptoms should consult a healthcare provider. The FDA is collecting reports of reactions, but none have been reported yet.

via CNET|
#contamination#fda#health