Tag

Pseudomonas Aeruginosa

All articles tagged with #pseudomonas aeruginosa

health1 month ago•2 min saved

Hypercalcemia mystery clarified and Cipro considerations for Pseudomonas

Dr. Roach reviews a 65-year-old with a very high calcium level (14 mg/dL). Although serious causes are possible, extensive testing and a good recovery years later make them unlikely; the most common cause is primary hyperparathyroidism, but pseudohypercalcemia from abnormal blood proteins or tourniquet artifact can mimic true hypercalcemia, and measuring ionized calcium can help confirm. In a second letter, he explains that treating Pseudomonas infections often requires ciprofloxacin, despite its risks, and that IV antibiotics may be needed if symptoms demand it; only treat when infection is likely (not just colonization), and monitor interactions with diuretics like hydrochlorothiazide.

via The Detroit News|

#ciprofloxacin #health #hypercalcemia

science1 month ago•66 min saved

In-host gene transfer sparks explosive antibiotic resistance in lung infections

A multicenter study of chronic lung infections in cystic fibrosis and bronchiectasis patients found that extreme tobramycin resistance emerged not by mutation but via in vivo transfer of resistance genes from transient environmental bacteria to already-established pathogens in the lungs. The transferred plasmids carried aac(3)-IIId on a transposon (TnCF1) and conferred MICs ≥1,024 µg/mL, producing roughly 10,000-fold resistance that persisted for years. Plasmids were stable with low fitness costs, aided by toxin–antitoxin systems, and several donor species (including Pseudomonas putida) likely carried the plasmids into patients before transferring them to pathogens, with transfer demonstrated ex vivo via conjugation or transformation. The findings imply that resistance can rapidly arise during therapy through within-host gene transfer, underscoring the need for environmental surveillance and strategies to limit in vivo gene exchange.

via Nature|

#antibiotic-resistance #horizontal-gene-transfer #plasmids

business7 months ago•4 min saved

Angry Orange Enzyme Stain Removers Recalled Over Bacteria Risk

Thrasio is recalling Angry Orange Enzyme Stain Removers after detecting potential bacterial contamination, including Pseudomonas aeruginosa. About 1.5 million units in the U.S. (roughly 43,700 in Canada) sold from 2019–2025 are affected. Consumers should stop using the recalled products and obtain a full refund by emailing a photo of the product marked with “recalled” and their initials; dispose of the product in household trash without emptying it. No injuries have been reported. The products were sold at major retailers and online. Recall date: January 22, 2026.

via U.S. Consumer Product Safety Commission (.gov)|

#angry-orange #bacteria #business

science7 months ago•20 min saved

Far-Red Light Triggers Tiny Protein to Silence Biofilms in Antibiotic-Resistant Bacteria

A Nature Communications study reports that far-red light activates the periplasmic microprotein DimA in antibiotic‑resistant Pseudomonas aeruginosa, triggering a cascade that represses biofilm formation and reduces virulence; virulence promoters are not activated under far-red light, and bacteria with disrupted photosensing showed higher virulence, suggesting a potential light‑based approach to complement antibiotics. The researchers also hint at overexpressing DimA to further prevent biofilm formation.

via Ground News|

#biofilm #dima #far-red-light

science1 year ago•3 min saved

Hospital Superbug Capable of Digesting Medical Plastic, Study Finds

Researchers discovered that the hospital pathogen Pseudomonas aeruginosa can produce an enzyme called Pap1 that allows it to break down and feed on plastic, potentially impacting the use of plastics in medical settings and highlighting the need for antimicrobial solutions in medical plastics.

via ScienceAlert|

#hospital-pathogens #medical-plastics #microbe

health1 year ago•3 min saved

CDC Warns of Rare Diseases Spread by Pet Dogs

The CDC has reported that pet dogs in New Jersey and Wisconsin have been linked to two rare diseases. In New Jersey, two dogs were infected with antibiotic-resistant Pseudomonas aeruginosa, similar to a strain that caused a human outbreak linked to artificial tears. In Wisconsin, a fungal outbreak of Blastomyces affected both humans and dogs, with spores likely inhaled from disturbed soil. While direct transmission from dogs to humans is rare, the environments where dogs are exposed may also pose risks to humans.

via Daily Mail|

#antibiotic-resistant #blastomycosis #cdc

health-and-science2 years ago•5 min saved

"Personalized Bacteriophage Therapy Saves Cat After Three-Story Fall"

A cat named Squeaks, suffering from a persistent infection after a severe leg injury, was successfully treated using personalized bacteriophage therapy. This groundbreaking approach, which targets specific bacteria with viruses, marks the first reported use of such treatment in academic veterinary medicine. The therapy, combined with antibiotics, healed the infection after other antibiotics had failed, highlighting the potential of phage therapy for treating antibiotic-resistant infections in pets.

via Haaretz|

#antibiotic-resistance #bacteriophage-therapy #health-and-science

veterinary-medicine2 years ago•3 min saved

"Phage Therapy Cures Resistant Wounds in Siamese Cat"

A study led by Prof. Ronen Hazan demonstrated the successful use of personalized phage therapy to treat a multidrug-resistant Pseudomonas aeruginosa infection in a Siamese cat named Squeaks. This marks the first documented application of such therapy in veterinary medicine, highlighting its potential to address antibiotic-resistant infections in animals. The treatment involved a combination of a specific anti-P. aeruginosa phage and ceftazidime, leading to the complete healing of the cat's surgical wound after fourteen weeks.

via Phys.org|

#antibiotic-resistance #phage-therapy #pseudomonas-aeruginosa

health-and-science2 years ago•2 min saved

"Engineering Viruses to Assassinate Superbugs: A Promising Solution"

Researchers have discovered a virus, named Paride, that can target and kill dormant bacteria, including the dangerous Pseudomonas aeruginosa, when combined with the antibiotic meropenem. This breakthrough could offer a new strategy in the fight against drug-resistant bacteria, or superbugs, which are increasingly resistant to existing drugs. The virus seems to unlock the bacteria's defenses, allowing the antibiotic to effectively destroy it. While this discovery holds promise, further research is needed to fully understand and harness the potential of using bacteriophages to combat superbugs.

via ScienceAlert|

#antibiotic-resistance #bacteriophages #health-and-science

science-and-technology2 years ago•59 min saved

Unveiling the Evolution and Mystery of Bacteria's Weaponry

Bacteria commonly evolve weapons to compete with other organisms. Pseudomonas aeruginosa, an opportunistic pathogen, produces multiple bacteriocins and toxic small molecules as long-range weapons, and can deploy contact-dependent inhibition (CDI) systems and type VI secretion systems (T6SSs) as short-range weapons. A study using an agent-based model and experiments with P. aeruginosa found that short- and long-range weapons serve different functions during competition. Contact weapons are effective even when attackers are outnumbered, facilitating invasion and establishment, while ranged weapons are most effective when attackers are abundant. These findings highlight the evolutionary basis for the prevalence of multiple weapons in bacteria.

via Nature.com|

#bacteria #competition #evolution

science3 years ago•4 min saved

Small RNA regulates transition between chronic and acute bacterial infections.

Researchers at the Georgia Institute of Technology have identified a small RNA, named SicX, that regulates the transition between chronic and acute Pseudomonas aeruginosa infections. The gene that drives the switch, PA1414, was found to be highly expressed in human tissue samples of chronic bacterial lung and wound infections. The researchers also found that low oxygen drives the high expression of the gene. SicX potentially serves as a biomarker for the chronic-to-acute switch, which could lead to better predictions of when an infection might become life-threatening and the development of targeted therapeutics.

via Phys.org|

#acute-infections #bacterial-infection #chronic-infections

health3 years ago•4 min saved

Fatalities Increase as Contaminated Eye Drops Outbreak Spreads

The death count from a bacterial infection linked to contaminated eyedrops has risen to four, with 13 more patients suffering vision loss, bringing the total infection count to 81. All patients had caught a rare strain of the bacteria Pseudomonas aeruginosa that is resistant to standard antibiotics and can 'melt' through the eyes to reach the bloodstream and vital organs in the body. Health authorities are urging people not to use EzriCare and Delsam Pharma-branded drops, which were made at an Indian factory with several infection control failings.

via Daily Mail|

#antibiotic-resistance #bacterial-infection #contaminated-eyedrops

health3 years ago•1 min saved

Contaminated eyedrops claim fourth victim in outbreak.

The death toll from contaminated eyedrops has reached four, with 81 people infected, according to the Centers for Disease Control and Prevention. The eyedrops were recalled in February after being linked to multiple infections from a rare strain of Pseudomonas aeruginosa, which is resistant to standard antibiotics. Patients who used the drops developed ulcers over their corneas, which leaked yellow-colored discharge before ultimately becoming blinded. Several people who have been infected from the drops are suing Global Pharma, the India-based manufacturer where the bacterial outbreak originated.

via New York Post |

#bacterial-outbreak #cdc #contaminated-eyedrops

health3 years ago•2 min saved

Tainted eye drops cause 4 deaths and vision loss outbreak.

The CDC has reported an additional death and six more cases of vision loss linked to infections from eye drops recalled due to bacterial contamination. Four deaths and 14 cases of vision loss in total have now been reported among more than 80 infections of a rare strain of drug-resistant Pseudomonas aeruginosa that had never been identified in the United States prior to this outbreak. The FDA and CDC have urged consumers to stop using the recalled products.

via KABC-TV|

#bacterial-contamination #cdc #eye-drops

health3 years ago•1 min saved

CDC Reports 4 Deaths and 81 Cases in Contaminated Eye Drops Outbreak.

A fourth person has died from an outbreak of Pseudomonas aeruginosa, an extensively drug-resistant bacteria linked to Global Pharma Healthcare's recalled eyedrops. As of May 15, 81 patients across 18 states have become infected, with 14 reporting vision loss, four having their eyeballs removed, and four others dying. The CDC has been investigating the outbreak, which has been tied to artificial tears manufactured by Global Pharma Healthcare earlier this year, and has issued a recall for all lots within the expiry of the EzriCare and Delsam Pharma’s artificial tears products due to possible contamination.

via Fox Business|

#cdc #drug-resistant-bacteria #global-pharma-healthcare