Tag

Y Chromosome

All articles tagged with #y chromosome

science1 month ago•5 min saved

The Aging Y: How Losing the Y Chromosome Could Impact Men’s Health

As men age, some cells can lose the Y chromosome, a change linked to higher risks of cancer, kidney and heart disease, Alzheimer's, and earlier death. Evidence from human studies and mouse models shows Y loss may impair immune function and cancer defense, and a sizable share of older men harbor Y-loss in tissues such as blood and tumors (e.g., bladder cancer). Ongoing debate asks how essential Y genes are and whether other chromosomes can compensate, though the chromosome has shrunk to roughly 3% of its ancestral genes and may not be doomed to vanish.

via ScienceAlert|

#aging #cancer #genetics

science2 months ago•6 min saved

Y Chromosome on the Clock: Extinction Fears Meet Scientific Debate

The fate of the human Y chromosome is still debated: it has shed most of its ancestral genes, but scientists disagree on whether it will disappear. Some argue key Y genes are essential and loss is limited, while others say remaining sequences are repeats and degradation could continue. Animal studies showing sex-determination relocating to other chromosomes suggest humans might compensate if needed; even if the Y vanishes, males would likely persist, and extinction is not imminent.

via Indian Defence Review|

#chromosomes #evolution #genetics

science2 months ago•8 min saved

Is the Y Chromosome Doomed—or Here to Stay?

ScienceAlert covers a heated debate: Jenny Graves argues the Y chromosome is degrading and could vanish in millions of years, but this forecast is contested and uncertain. Other researchers, notably MIT’s Jenn Hughes, contend core Y genes are deeply conserved in primates and the chromosome is more likely to persist, even as some species have shed or replaced its sex-determining role. The evidence shows sex-determination systems can evolve rapidly, and while the Y’s fate remains unresolved with wide error margins, males would likely persist if alternative mechanisms arise.

via ScienceAlert|

#evolution #genetics #primates

science4 months ago•6 min saved

Y Chromosome Fades, Yet Males Persist: Amami Spiny Rat Reveals a New Route to Maleness

New research shows the Y chromosome is decaying in mammals, but the Amami spiny rat demonstrates that maleness can be controlled by an autosomal SOX9 enhancer—driven by a 17,000-base-pair duplication on chromosome 3—allowing male development without the SRY gene. This turnover indicates that the Y’s loss does not doom a species and suggests other mammals may use alternative genetic switches, though the exact mechanisms vary and require further study.

via The Daily Galaxy|

#amami-spiny-rat #evolution #science

science5 months ago•7 min saved

Aging Men Lose the Y Chromosome—and Health Risks Rise

As men age, many cells lose the Y chromosome, creating a mosaic of Y-bearing and Y-less cells. Loss frequency climbs with age (roughly 40% at age 60 and 57% by age 90) and is linked to higher risks of cardiovascular and neurodegenerative diseases, cancer, and even mortality in some studies, though causation isn’t proven. Environmental factors like smoking and genetic susceptibility influence Y loss. Some animal studies suggest Y deficiency can accelerate age-related pathology, and the Y’s regulatory and non-coding genes may impact gene expression and immune function, indicating the Y chromosome has functional roles beyond sex determination that merit further investigation.

via ScienceAlert|

#aging #cancer #cardiovascular-disease

health5 months ago•67 min saved

Aging Men Lose Y Chromosome, Linked to Health Risks

New research shows that the Y chromosome is frequently lost in aging men’s cells, with about 40% of 60-year-olds and 57% of 90-year-olds showing Y loss. This mosaic loss is linked to higher risks of cardiovascular disease, neurodegenerative conditions, and cancer, prompting speculation that Y loss could contribute to shorter lifespans. However, causality is not established, and scientists are still unraveling the mechanisms and whether the Y loss is a cause or a consequence of disease.

via Live Science|

#aging #cardiovascular-disease #genetics

archaeology5 months ago•62 min saved

Southern Greek 'genetic island' preserves Bronze Age paternal roots

A genetic study of the Deep Maniots, a small, isolated community in southern Greece, finds an unusually strong paternal lineage dating back to a Caucasus origin about 28,000 years ago and little evidence of Migration Period Germanic/Slavic input. Maternal lineages are more diverse, with several Bronze/Iron Age connections; both paternal and maternal lineages show founder effects around AD 380–670 and 540–866, respectively, highlighting long-term isolation and a patriarchal clan structure that preserved ancient Greek ancestry in the Deep Mani region.

via Live Science|

#archaeology #deep-maniots #founder-effect

health1 year ago•5 min saved

Y Chromosome Loss and Its Impact on Men's Health and Aging

A new study reveals that loss of the Y chromosome (LOY) in men is directly linked to increased cancer risk, immune system impairment, and reduced lifespan, with LOY becoming more common with age and potentially serving as a biomarker for cancer and other age-related diseases.

via Earth.com|

#cancer-risk #genetics #health

science1 year ago•5 min saved

Disappearing Y Chromosome Threatens Men's Health and Cancer Outcomes

The Y chromosome is gradually disappearing over millions of years, which could impact male development and health, but some species have evolved alternative mechanisms. In humans, Y chromosome loss already affects a significant portion of men, linked to health risks like cancer and heart disease. Lifestyle choices and medical interventions may help mitigate these effects, while evolutionary biology explores potential future adaptations.

via Earth.com|

#chromosome-loss #evolution #genetics

science-and-technology2 years ago•8 min saved

"First Complete Primate Chromosome Maps Illuminate Human Evolution"

Researchers have created the first complete chromosome sequences from non-human primates, revealing significant variations in Y chromosomes among species. This study provides new insights into the rapid evolution of these chromosomes and previously unexplored regions of great ape genomes, offering valuable information for understanding human evolution and primate genetic diversity.

via Neuroscience News|

#genetic-diversity #human-evolution #nih-research

science2 years ago•2 min saved

"The Future of Men: Debating the Disappearing Y Chromosome"

Scientists are divided over the implications of the disappearing Y chromosome, with some speculating potential fertility problems and the emergence of a new species, while others believe that the SRY gene may move to another chromosome or that genetic engineering could replace the Y chromosome altogether. The Y chromosome has been degrading over the estimated 3.5 million years of human existence and may have roughly 4.6 million years left before it disappears from our DNA, but there is no immediate cause for alarm.

via UNILAD|

#evolution #future #genetics

science2 years ago•6 min saved

"The Vanishing Y Chromosome: Implications for the Future of Men"

The Y chromosome, responsible for determining male sex, has been degenerating for millions of years and may disappear, potentially leading to the extinction of men. However, other species have lost the Y chromosome and survived by evolving new sex determining genes. If the Y chromosome disappears in humans, it could lead to the evolution of new sex determining genes, potentially resulting in the separation of different human species.

via indy100|

#evolution #genetics #human-extinction

science2 years ago•4 min saved

"The Vanishing Y Chromosome: Implications for the Future of Men"

The Y chromosome is degrading at a concerning rate, with the potential to vanish in about 4.5 million years due to gene loss and difficulty in eliminating mutations. Some animal species have already witnessed the disappearance of the Y chromosome, but there are potential mechanisms for genes to relocate and maintain male sex determination. While there are advocates for the Y chromosome's lasting, its changes could impact disease risks in men, potentially affecting cancer and Alzheimer's disease. However, with various potential extinction scenarios, there's no immediate need for concern about the Y chromosome disappearing.

via Yahoo Life|

#evolution #genetics #health-risks

science2 years ago•4 min saved

"The Mystery of the Disappearing Y Chromosome"

The Y chromosome is degrading at a concerning rate, with the potential to vanish in about 4.5 million years due to gene loss and difficulty in eliminating mutations. Some animal species have already witnessed the disappearance of the Y chromosome and SRY gene, impacting sex determination. While some scientists believe in the Y chromosome's lasting, others warn of potential health risks such as cancer and Alzheimer's disease if it continues to change. However, given the long timeline and potential extinction scenarios, immediate concern may not be necessary.

via Deseret News|

#evolution #genetics #human-health

science2 years ago•4 min saved

The Uncertain Future of Men: The Vanishing Y Chromosome

The Y chromosome is degrading at a concerning rate, with the human Y chromosome expected to vanish in about 4.5 million years due to the loss of genes and difficulty in eliminating mutations. Some animal species have already witnessed the disappearance of the Y chromosome, but there is hope as scientists have identified DNA sequences that can compensate for the loss of the SRY gene. While some researchers advocate for the Y chromosome's lasting, others warn of potential health risks associated with its loss, including an increased risk of developing Alzheimer’s disease, cancer, and cardiovascular disease. However, given the long timeline and potential extinction scenarios, there is no immediate cause for concern.

via Deseret News|

#biology #evolution #genetics