Tag

Brown Fat

All articles tagged with #brown fat

science5 days ago•4 min saved

New Enzyme Pocket Regulates Brown Fat Heat and Bone Health

McGill researchers identified a glycerol pocket in the TNAP enzyme that activates the futile creatine cycle in brown fat, providing a separate heat-producing pathway from the classic UCP1 system in mice. The work links TNAP activity to bone mineralization, with genetic data suggesting glycerol-pocket mutations correlate with lower bone density. While promising for new therapies for skeletal disease and possibly obesity/diabetes, the findings are early and focus on enzyme activation and potential TNAP activators.

via ScienceAlert|

#bone-health #brown-fat #fat-burning

science9 days ago•7 min saved

Hidden Switch in Brown Fat Could Boost Heat and Strengthen Bones

Scientists have identified a molecular on-switch in brown fat that activates a hidden heat-producing pathway called the futile creatine cycle when glycerol binds to the TNAP enzyme in a glycerol pocket. In mice, this switch not only drives heat production but also influences bone mineralization, since TNAP is essential for calcification, suggesting new approaches to treat bone diseases such as hypophosphatasia by boosting TNAP activity. The findings, published in Nature, build on prior work and point to potential drug candidates for future testing.

via SciTechDaily|

#bone-mineralization #brown-fat #futile-creatine-cycle

health11 days ago•2 min saved

Cold wearables may trim fat: study finds modest weight loss with ice-vest use

In a six-week study of 47 adults with overweight/obesity, wearing an ice vest and waist wrap for two hours each morning led to a 0.9 kg loss of fat (while controls gained 0.6 kg), suggesting cold exposure activates brown fat and could aid weight loss alongside diet and exercise; researchers are also testing whether cold showers yield similar results, noting differences like cold shock between methods.

via The Guardian|

#brown-fat #cardiovascular-health #cold-exposure

science2 months ago•8 min saved

SLIT3 Wiring in Brown Fat Boosts Calorie Burning and Heat Production

A Nature Communications study reveals brown fat uses SLIT3 fragments, produced by BMP1, to drive blood vessel and nerve growth essential for thermogenesis. In mice, removing SLIT3 or its receptor PLXNA1 impairs nerve and vascular networks and lowers heat production, while human fat analyses suggest SLIT3 activity may influence obesity and insulin sensitivity, pointing to therapies that increase energy expenditure rather than curb appetite.

via SciTechDaily|

#brown-fat #neurovascular #obesity

science-tech2 months ago•12 min saved

From Storage to Heat: Harnessing Fat's Energy-Burning Power for Weight Loss

Fat is not just storage: brown fat burns calories to generate heat, beige fat can arise within white fat, and both offer targets for obesity therapies. The next generation of treatments may combine GLP-1–based appetite suppression with methods to boost energy expenditure across fat, muscle, and liver, aiming for more durable weight loss while avoiding hunger-driven compensation. This reframes fat as a dynamic metabolic organ and points to a multi-tissue, precision approach to energy balance.

via The Conversation|

#adipose-tissue #beige-fat #brown-fat

health3 months ago•56 min saved

Beige fat around arteries may help lower blood pressure, mouse study suggests

A mouse study shows beige fat around blood vessels helps keep blood pressure low by suppressing the enzyme QSOX1; when beige fat is converted to white fat, QSOX1 rises, leading to stiffer vessels and higher BP. Removing beige fat or blocking QSOX1 prevented hypertension in mice, suggesting beige fat has a local vascular role and that QSOX1 could be a target for future hypertension therapies.

via Live Science|

#beige-fat #blood-pressure #brown-fat

health-and-fitness4 months ago•4 min saved

Do Cold Temperatures Boost Calorie Burn? Experts Explain

Exposing your body to cold weather can increase calorie burn through shivering and non-shivering thermogenesis, especially below 60-66°F, but factors like wind chill, clothing, and body composition influence the effect. While outdoor cold workouts offer a slight metabolic boost, proper clothing and gradual acclimation are essential for safety and effectiveness.

via AOL.com|

#brown-fat #calorie-burn #cold-weather

health-and-wellness5 months ago•12 min saved

Harnessing Cold and Shivering for Easy Weight Loss

Brown fat, a type of fat that burns calories to generate heat, can be activated by cold exposure, spicy foods, and caffeine, potentially improving metabolic health and aiding in weight management, though its direct impact on weight loss is limited. Regular cold exposure may boost brown fat activity and insulin sensitivity, but lifestyle factors like diet and exercise remain crucial for overall health.

via BBC|

#brown-fat #cold-exposure #health-and-wellness

science10 months ago•3 min saved

Brown Fat: The Body's Hidden Weight Loss Secret

Scientists have discovered a protein switch that activates brown fat's calorie-burning heat production, especially in cold conditions, which could lead to new obesity and metabolic disease treatments, although practical applications are still in early stages.

via SciTechDaily|

#brown-fat #metabolism #protein-switch

health2 years ago•10 min saved

"Exploring the Link Between Obesity and Metabolic Health: Research Findings"

Obesity and metabolic health are complex issues influenced by various factors. Research suggests that conscious control over food intake and type is limited, as the body's metabolism and appetite regulation play significant roles. Ultra-processed foods may contribute to overeating, while sleep deprivation can lead to weight gain and impaired insulin sensitivity. Additionally, the type of fat in the body matters, with brown fat being associated with better metabolic health. Activating brown fat through cold exposure or drugs like mirabegron shows promise in improving metabolic health. However, there is still much to learn and understand about obesity and metabolic health.

via National Institutes of Health (.gov)|

#brown-fat #diet #health

science-and-technology2 years ago•2 min saved

"Breakthrough: Unveiling the Long-Awaited Structure of Human Protein UCP1"

The structure of the human protein UCP1, which plays a role in releasing energy as heat in brown fat, has been obtained, providing valuable insights into its mechanism of action. This breakthrough could potentially aid in the development of drugs for obesity and other metabolism-related disorders.

via Nature.com|

#brown-fat #drug-design #obesity

health-and-science2 years ago•2 min saved

Unveiling the Power of GDF15: A Breakthrough in Obesity and Diabetes Treatment

Scientists have used a cryogenic electron microscope to unveil the atomic structure of UCP1, a protein found in "good" brown fat that plays a key role in calorie burning and thermogenesis. This breakthrough offers insights into potential treatments for obesity and diabetes by harnessing the activity of UCP1 in brown fat cells to promote weight loss and regulate glucose levels. The research provides the first detailed understanding of UCP1 and its potential for combating obesity and controlling diabetes.

via SciTechDaily|

#brown-fat #diabetes #health-and-science

health2 years ago•4 min saved

"Protein Molecular Structure Discovery: A Game-Changer in Fat Burning Research"

Scientists have discovered the molecular structure of a protein called UCP1, which enables brown fat tissue to burn calories as heat. This breakthrough could lead to the development of treatments that activate UCP1 to burn off excess calories from fat and sugar, potentially combating obesity and diabetes. The research provides crucial details for the development of therapeutics that target UCP1 and could help increase brown fat activity to burn more calories and fight metabolic diseases.

via SciTechDaily|

#brown-fat #diabetes #fat-burning

health2 years ago•9 min saved

The Vagus Nerve's Response to Cold Water

Strengthening the vagus nerve, which regulates heart rate, digestion, and inflammation, can be as easy as splashing cold water on your face. Stress is a major cause of vagus nerve weakening, leading to exhaustion, brain fog, anxiety, and depression. Cold water therapy, such as sipping cold water, applying a cold pack to your face, or ending your shower with cold water, can activate the vagus nerve and counteract the negative effects of stress. Other methods to tone the vagus nerve include humming, drinking bergamot tea, and practicing heart-focused breathing. Cold water therapy can also activate brown fat, which increases metabolism and helps with weight loss.

via Woman's World|

#brown-fat #cold-water-therapy #health

health3 years ago•4 min saved

"Revolutionary Discovery Unlocks Potential for Obesity Treatment"

Researchers have discovered the molecular structure of Uncoupling protein 1 (UCP1), a protein instrumental in the burning of calories in brown fat tissue, often referred to as ‘good fat’. The essential molecular details discovered could aid in the development of therapeutics to activate UCP1 artificially, thus enabling the burning of excess calories and potentially combating obesity and diabetes.

via SciTechDaily|

#brown-fat #diabetes #health