All articles tagged with #single cell
Chinese researchers have built the first 3D spatial single-cell atlas of the lamprey brain, enabling reconstruction of ancestral vertebrate brain features and revealing conserved gene expression and neurogenesis patterns with mammals; published as a Science cover article on June 19, 2026, the work suggests early vertebrate brains were already well-partitioned and provides a new resource for brain-evolution studies.
Researchers built IBDverse, the largest single-cell eQTL atlas for inflammatory bowel disease, mapping cis-eQTL effects across blood and gut tissues in about 400 individuals to link genetic risk to specific cell types. They find cell-type eQTLs are more distal, enhancer-rich, and far more likely to colocalize with IBD GWAS signals than bulk-tissue eQTLs, nominating effector genes such as MAML2 and ZMIZ1 in dendritic cells and MYC and RASGRP1 in colonocytes. Notch pathway regulators in dendritic cells and Wnt-driven epithelial renewal in colonocytes emerge as key mechanisms, tying regulatory variation to barrier dysfunction and inflammation. The study also highlights therapeutic angles—including PRKCB inhibitors and targets like ITGA4/JAK2—and provides a framework for interpreting GWAS loci via cell-type–resolved eQTL mapping in complex diseases.
Researchers used advanced scDVP to profile hundreds of hepatocytes from 18 people, building a high-resolution map of protein gradients along the liver's porto–central axis. They quantified ~2,500 proteins per cell, showed roughly half are zonated, and introduced gradient-based analysis to quantify zonation without binning. Cross-species comparison with mice revealed shared and human-specific zonation features; in tissues with disrupted architecture, zonation is broadly lost. The study delivers an open-access liver proteome resource and a framework applicable to spatial proteomics.