Tag

Tissue Engineering

All articles tagged with #tissue engineering

science24 days ago•13 min saved

Spider Silk Inspires Next-Gen Medical Materials for Drug Delivery and Wound Repair

Spider silk is guiding the development of new medical materials. Researchers extract silk genes and produce engineered silk proteins in microbes to create particles, gels, fibers, and 3D-printed scaffolds for drug delivery and tissue repair. These silk-based systems can biodegrade and release medicines over time, while providing biocompatible scaffolds that support cell growth and healing, with applications ranging from wound coverings to bone regeneration. The process leverages room‑temperature, water-based manufacturing that contrasts with traditional synthetic fibers.

via The Conversation|

#biomaterials #drug-delivery #science

science1 month ago•5 min saved

MIT magnets pattern lab-grown blood vessels

MIT researchers developed a magnetically controlled method to pattern and grow artificial blood vessels in a collagen gel, using a chip with an internal magnet actuated by external magnetic fields to tune vessel length and density. The approach offers a programmable way to create organized vascular networks for lab-grown tissues, though it remains early-stage and requires demonstration of perfusion and integration with organs.

via ScienceAlert|

#angiogenesis #bioengineering #magnetic-actuation

health1 month ago•41 min saved

Animal Study Signals Potential One-Dose Cure for Osteoarthritis

Colorado researchers report two regenerative approaches for osteoarthritis: a single, injectable therapy using a repurposed FDA-approved drug with a patented particle delivery system, and an engineered protein cocktail that patches cartilage by recruiting the body’s progenitor cells. In animal models, treated joints regained health within 4–8 weeks, and human cells from joint-replacement patients showed regenerative effects in vitro. Having completed Phase I, the team moves to Phase II under ARPA-H’s $30 million NITRO program, aiming for clinical trials in about 18 months and the potential for an affordable, single‑visit therapy to repair joints and avoid replacements.

via Good News Network|

#arthritis #clinical-trials #health

science3 months ago•5 min saved

Two-Step Growth Factor Therapy Sparks Regeneration in Mice

Texas A&M researchers showed that a two-step treatment—first applying FGF2 after wound closure, then BMP2—redirects local fibroblasts to form a blastema-like structure and triggers regrowth of bone, tendons, ligaments, and joints in mice after amputation. The regenerated tissues were not perfectly formed, but the main structures were restored, suggesting latent regenerative capacity in mammals and potential for reducing scarring. Because BMP2 is FDA-approved for some uses and FGF2 is in clinical trials, the approach could move toward clinical testing sooner rather than later.

via SciTechDaily|

#blastema #growth-factors #mammalian-healing

health4 months ago•70 min saved

Living knee implants could become your last knee replacement

Columbia University and the University of Missouri are developing NOVAKnee, a living knee implant made from a biodegradable scaffold seeded with stem‑cell–generated bone and cartilage. The scaffold is designed to degrade as new tissue forms, potentially offering longer‑lasting restoration with fewer revision surgeries than traditional metal/plastic implants. Backed by the NITRO program, the approach explores autologous and allogeneic cell options and will progress from small animals to large‑animal studies before first‑in‑human trials targeted for around 2028; if successful, it could become a platform technology for other joints.

via Live Science|

#health #knee-replacement #novaknee

technology4 months ago•7 min saved

Dino-Derived Luxury: World’s First Lab-Grown T. rex Leather Handbag Debuts

At the Art Zoo Museum in Amsterdam, the world’s first handbag crafted from lab-grown Tyrannosaurus rex leather debuted, created through AI-driven reconstruction of T. rex DNA and a proprietary tissue-engineering platform. The teal bag, designed by Enfin Levé, is biodegradable, cruelty-free, and will be auctioned with a starting price above $500,000; organizers envision expanding the material to luxury brands and other sectors.

via Dallas Express|

#ai-modeling #lab-grown-leather #luxury-fashion

science5 months ago•8 min saved

Lab Grows Functional Hair Follicles, Advancing Hair-Loss Treatments

Scientists have grown fully developed, functional hair follicles in the lab by adding a third cell type—accessory mesenchymal cells—alongside epithelial stem cells and dermal papilla cells. This three-cell recipe enables follicles to mature and cycle like natural hair, with potential implications for hair restoration and broader regenerative medicine, though translating the approach to humans remains a key challenge.

via Indian Defence Review|

#hair-follicles #hair-loss #in-vitro

science5 months ago•4 min saved

Lab-Grown Hair Follicles Reach Growth Milestone in Mice

Researchers created fully functional hair follicles in the lab using a three-cell recipe (epithelial stem cells, dermal papilla cells, and accessory mesenchymal cells), enabling growth cycles and tissue attachment in mice; this marks progress toward lab-grown hair restoration and organ regeneration, though human trials are not yet underway and scaling/transplantation remain challenges. OrganTech partly funded the work, and the findings were published in Biochemical and Biophysical Research Communications.

via ScienceAlert|

#hair #hair-follicle #organ-regeneration

science-and-technology1 year ago•4 min saved

Revolutionary 3D-Printed Device Enhances Tissue Engineering Precision

A tiny 3D-printed device called STOMP significantly enhances the precision and complexity of tissue engineering, enabling better modeling of human tissues and diseases by allowing precise cell patterning and interfaces, with potential applications in studying complex biological interactions.

via SciTechDaily|

#3d-printing #biomedical-research #microfluidic-device

science1 year ago•3 min saved

Revolutionary Bioprinter Produces Human Tissue in Record Time

Researchers at Penn State have developed a new 3D bioprinting technique called High-throughput Integrated Tissue Fabrication System for Bioprinting (HITS-Bio), which can rapidly produce complex biological tissues using cell clusters known as spheroids. This method is ten times faster than existing techniques and maintains high cell viability, enabling the creation of functional tissues and potentially accelerating organ replacement and disease modeling. The technique has shown promising results in rat models, significantly speeding up bone repair.

via Interesting Engineering|

#3d-bioprinting #medical-innovation #penn-state

science1 year ago•6 min saved

Breakthrough in Artificial Cells: Self-Sustained Protein Transport Achieved

Scientists have developed a method for artificial cells to autonomously modify their membranes, enabling protein transport and tissue assembly without complex external modifications. This breakthrough, using α-hemolysin, could advance tissue engineering and drug delivery by allowing artificial cells to interact with their environment and form tissue-like structures. The study highlights the potential for creating more complex artificial tissues and improving drug delivery systems.

via Phys.org|

#a-hemolysin #artificial-cells #membrane-functionalization

science-and-technology1 year ago•2 min saved

Blood Transformed into Bone-Healing Material for Personalized Implants

Researchers at the University of Nottingham have developed a 'biocooperative' material using blood and peptide molecules to enhance tissue regeneration, potentially leading to personalized, 3D-printed implants. This innovative approach leverages the natural healing processes of blood to create regenerative materials that can repair bones and other tissues. The method involves mixing synthetic peptides with a patient's blood to form a material that mimics and enhances the natural regenerative hematoma, offering a promising new avenue for regenerative medicine.

via Phys.org|

#3d-printing #biomaterials #blood

science-and-technology1 year ago•2 min saved

Scientists Engineer Photosynthetic Hamster Cells with Solar Power

Researchers in Japan have successfully created photosynthetic animal cells by injecting chloroplasts from red algae into hamster cells, enabling them to photosynthesize light. This breakthrough, detailed in the journal Proceedings of the Japan Academy, challenges previous assumptions about the incompatibility of chloroplasts and animal cells. The innovation could have practical applications in artificial tissue engineering, potentially solving oxygenation issues in lab-grown tissues. The study found that these "planimal" cells not only produce oxygen but also have a higher growth rate, suggesting additional benefits from the chloroplasts.

via Gizmodo|

#animal-cells #biotechnology #chloroplasts

science1 year ago•2 min saved

Scientists Engineer Photosynthetic Animal Cells with Chloroplasts

Japanese researchers have successfully transplanted photosynthetically active chloroplasts from algae into animal cells, specifically Chinese hamster ovary cells, marking the first time photosynthetic electron transport has been confirmed in animal cells. This breakthrough could lead to advancements in tissue engineering, such as creating artificial organs that can grow in low oxygen environments by incorporating chloroplasts to supply oxygen through light exposure. However, further research is needed to maintain chloroplast functionality in animal cells for extended periods.

via WIRED|

#animal-cells #biotechnology #chloroplasts

science-and-technology2 years ago•4 min saved

"Revolutionizing Biotechnology: 3D Ice Printing for Artificial Blood Vessels and Organs"

Scientists are using 3D-printed ice sculptures as temporary scaffolds to grow human cells into blood vessel-like structures, demonstrating the potential for creating realistic, lab-grown blood vessels from human cells. The ice printing technique, known as 3D-ICE, allows for the creation of smooth, free-flowing shapes at tiny scales, and could be used to engineer blood vessels that capture the complex geometries of real vascular networks in the body. This method may offer advantages over current artificial blood vessels and could also be helpful for crafting organ-on-a-chip devices. While it will be some time before this technique could be used for human patients, it shows promise for tissue engineering and biomedical applications.

via Livescience.com|

#3d-printing #biomedical-engineering #blood-vessels