Tag

Masld

All articles tagged with #masld

Eggs and Liver Health: A Hepatologist Explains the Nuanced View
health8 days ago

Eggs and Liver Health: A Hepatologist Explains the Nuanced View

A hepatologist notes that eggs sit in a gray area for liver health: they provide satiating protein and choline that can support the liver, but their cholesterol content means effects vary with overall diet and metabolic health. Studies on egg intake and MASLD/NAFLD conflict—some show higher risk with limited eggs, others show no association and suggest choline may be protective. For healthy individuals, 1–2 eggs daily can fit in a balanced diet, but those with high cholesterol may want to eat them less often. Emphasize liver-friendly breakfasts with whole foods (Greek yogurt or plant proteins, fiber-rich toast with avocado) and beverages like coffee/tea, while avoiding sugar-heavy pastries and fruit juice and limiting processed meats.

Pantry Power: Spices and Teas That May Help Fatty Liver Health
health11 days ago

Pantry Power: Spices and Teas That May Help Fatty Liver Health

Fatty liver disease affects about a quarter of adults worldwide. The article highlights pantry staples—saffron (Crocin II), turmeric, ginger, green tea, and garlic—as potential natural aids to reduce liver fat and inflammation, especially when combined with weight loss, regular exercise, and a balanced diet; it also notes caution with high-dose saffron or supplements and recommends using these foods in food rather than relying on supplements.

Beyond Booze: 9 Everyday Habits That Could Harm Your Liver
health1 month ago

Beyond Booze: 9 Everyday Habits That Could Harm Your Liver

Nine everyday factors beyond alcohol can silently stress the liver, per Dr. Pramod Kumar D A: refined fructose in drinks and packaged foods that can contribute to MASLD (formerly NAFLD); risk from mixing acetaminophen-containing medicines; herbal supplements can still harm the liver; chronic sleep deprivation disrupts the liver’s circadian rhythm; excessive vitamin A from supplements; exposure to household chemicals; secondhand smoke; hidden trans fats in processed foods; and dehydration. Practical steps include reading labels, avoiding unnecessary supplements, choosing water over sugary drinks, maintaining a consistent 7–9 hour sleep schedule, ventilating spaces during cleaning or painting, staying hydrated, and keeping a healthy weight through activity.

Liver Health Fever Sparks Supplement Surge, Doctors Warn Against Quick Fixes
health1 month ago

Liver Health Fever Sparks Supplement Surge, Doctors Warn Against Quick Fixes

Rising interest in liver health is driving a surge in supplements and online content, but hepatologists warn that most products lack solid evidence and can be harmful; the liver’s role extends beyond detox, and the recommended approach is maintaining a healthy weight, a Mediterranean-style diet, regular exercise, limited alcohol, and routine liver-screening tests to monitor MASLD/NAFLD risk.

Black Coffee May Help the Liver, But It's Not a Cure
health1 month ago

Black Coffee May Help the Liver, But It's Not a Cure

Emerging research suggests regular black coffee is associated with healthier liver markers and a lower risk of progression to advanced fibrosis in fatty liver disease (MASLD), likely due to caffeine, chlorogenic acid, and antioxidants that reduce inflammation and oxidative stress. Benefits appear with moderate intake (about 2–3 cups daily) of black coffee; sugary or high-calorie coffee drinks can negate these effects. Coffee should complement, not replace, lifestyle measures like weight management, exercise, diet, and medical care.

Dual-agonist survodutide reduces liver fat and weight in phase 3 MASLD trial
health2 months ago

Dual-agonist survodutide reduces liver fat and weight in phase 3 MASLD trial

In the SYNCHRONIZE-MASLD phase 3 trial, 216 adults with obesity and metabolic dysfunction-associated steatotic liver disease received weekly survodutide 6.0 mg or placebo for 48 weeks. Survodutide met both co-primary endpoints, with 84.2% achieving ≥30% reduction in liver fat content (MRI-PDFF) versus 24.3% on placebo, and significant weight loss compared with placebo. About six in ten treated participants reached normalization of liver fat. The study used a dose-escalation period to 6.0 mg followed by a maintenance phase and included extensive safety monitoring. Secondary endpoints showed favorable changes in liver enzymes, liver stiffness/volume, insulin resistance, and other noninvasive liver tests. These results support survodutide as a potential therapy for obesity and MASLD, with data sharing and ongoing follow-up planned.

Sorbitol May Fuel Fatty Liver When Gut Bacteria Falter
health2 months ago

Sorbitol May Fuel Fatty Liver When Gut Bacteria Falter

A Washington University study shows sorbitol can be converted to fructose in the liver when gut bacteria that normally degrade it are depleted, leading to fat accumulation in the liver in zebrafish and suggesting higher MASLD risk with excessive sorbitol intake or disrupted gut microbiota; gut bacteria may mitigate this by metabolizing sorbitol to harmless byproducts under normal conditions.

Green Mediterranean Plan Reverses Fatty Liver and Boosts Weight Loss
wellness2 months ago

Green Mediterranean Plan Reverses Fatty Liver and Boosts Weight Loss

MASLD (formerly NAFLD) can improve with lifestyle changes and, for some patients, medications. The article recommends swapping refined carbs for leafy greens and liver-friendly foods like avocado, berries, apples, eggs, wild salmon, walnuts and flaxseed; adopting a Green Mediterranean pattern rich in polyphenols; sipping coffee or green tea and avoiding drinks with added sugar; moving about 30 minutes most days plus more daily steps; prioritizing 7–8 hours of sleep, finishing meals 2–3 hours before bed, and using a 10-hour eating window; and, for certain patients, prescription rezdiffera/resmetirom (FDA-approved for NASH). Ozempic is used off-label by some clinicians to address obesity/insulin resistance, and statins may lower cardiovascular risk in MASLD. Many readers report improved liver fat and weight loss with these strategies, but medical guidance is essential for personalized care.

Processed Fructose in Everyday Foods Linked to Metabolic Disease
nutrition4 months ago

Processed Fructose in Everyday Foods Linked to Metabolic Disease

A Healthline summary highlights a Nature Metabolism review suggesting that fructose—especially from ultra-processed foods and sugar-sweetened beverages—may drive obesity and metabolic diseases by promoting fat production in the liver and disrupting metabolic pathways, with cautions that whole fruit is fine and a focus on reducing added fructose in processed foods.

Old Drugs, New Hope: Combo Reverses Fatty Liver in Animal Models
health-and-medicine4 months ago

Old Drugs, New Hope: Combo Reverses Fatty Liver in Animal Models

University of Barcelona researchers found that pairing two approved drugs, pemafibrate and telmisartan, reversed liver fat in MASLD animal models and may reduce cardiovascular risk; the duo was effective at half-doses together, suggesting synergy and safer therapy. Telmisartan appears to upregulate PCK1, shifting metabolism away from lipid synthesis. Human trials are still needed.

Even 'Healthy' Drinks Can Damage Your Liver, Hepatologists Warn
health4 months ago

Even 'Healthy' Drinks Can Damage Your Liver, Hepatologists Warn

Hepatologists warn that the liver can be damaged not only by alcohol but also by everyday drinks—especially fruit juice—because MASLD (metabolic dysfunction-associated steatotic liver disease) can develop from metabolic syndrome. Excessive fruit juice can cause weight gain and insulin resistance, leading to fat buildup in the liver; fiber and whole fruit help protect the liver. Limit fruit juice, read sugar content, and consult a clinician or dietitian to tailor intake.

p21+TREM2+ Senescent Macrophages Drive Inflammaging and MASLD, Reversed by Senolytics
science4 months ago

p21+TREM2+ Senescent Macrophages Drive Inflammaging and MASLD, Reversed by Senolytics

A Nature Aging study identifies a distinct population of p21+ Trem2+ senescent macrophages as major drivers of inflammaging. These cells exhibit a SASP and type I interferon signaling driven in part by cytosolic mitochondrial DNA, accumulate in aging livers and in metabolic dysfunction-associated steatotic liver disease (MASLD), and are distinct from classic M1/M2 macrophages. In both mouse models and human tissue, senolytic treatment with ABT-263 reduces liver inflammation and steatosis, supporting macrophage senescence as a tractable target for aging-related liver disease.

CBD and CBG Reprogram Liver Energy to Reverse Fatty Liver in Mice
health4 months ago

CBD and CBG Reprogram Liver Energy to Reverse Fatty Liver in Mice

Israeli researchers found that non-psychoactive cannabis compounds CBD and CBG can reverse liver damage in obese mice with MASLD by reprogramming liver energy use, boosting phosphocreatine reserves and lysosomal activity, and improving insulin resistance and lipid profiles. The treated mice showed reduced fat accumulation and inflammation without dietary changes, suggesting a new metabolic pathway to target in MASLD. However, these results are preclinical, and human relevance requires careful dosing considerations and clinical trials, as consumer CBD/CBG products vary in purity and concentration.

CBD and CBG Reprogram Liver Energy to Reverse Fatty Liver in Mice
science5 months ago

CBD and CBG Reprogram Liver Energy to Reverse Fatty Liver in Mice

In obese mice fed a high-fat diet, CBD and CBG improved liver function, reduced hepatic fat, lowered blood lipids, and enhanced insulin sensitivity, with CBG generally more effective. The benefits appear to arise from reprogramming hepatic energy and lysosomal pathways rather than activating classic cannabinoid receptors, and were achieved via abdominal injections. While promising for MASLD, human relevance remains to be tested and CBD product quality is variable.