Tag

Preclinical Trials

All articles tagged with #preclinical trials

Nanotherapy Delivers Tapeworm Drug to Endometriosis Cells in Mouse Trial
medical-research9 days ago

Nanotherapy Delivers Tapeworm Drug to Endometriosis Cells in Mouse Trial

Researchers at Washington State University have developed a nanotherapy that delivers the anti-parasitic drug niclosamide directly to immune cells associated with endometriosis. In mouse models, this approach reduced lesion growth and pain symptoms after a single dose, offering a potential non-hormonal alternative to current treatments. The study addresses the limitations of oral niclosamide, which has poor solubility and causes side effects, by using a dendrimer nanocarrier to target specific macrophages. While promising, the therapy remains in the preclinical stage, with human trials and FDA approval potentially taking five years or more.

Engineered Bacteria Poised to Infiltrate and Eat Tumors From Inside
science6 months ago

Engineered Bacteria Poised to Infiltrate and Eat Tumors From Inside

Researchers at the University of Waterloo are developing engineered Clostridium sporogenes that can colonize the oxygen-poor core of solid tumors and survive near the tumor’s outer layers by a quorum-sensing–controlled oxygen-tolerance gene, enabling tumor consumption from inside with GFP-based validation and plans for preclinical tumor testing.

Engineered Bacteria Eat Tumors from the Inside
science7 months ago

Engineered Bacteria Eat Tumors from the Inside

Researchers at the University of Waterloo engineered the soil bacterium Clostridium sporogenes to colonize oxygen-poor solid tumors and consume nutrients, effectively attacking tumors from within. They added oxygen-tolerance tweaks and quorum-sensing controls, plus a fluorescent signal, to signal successful tumor disruption. While promising, the approach is still in preclinical stages with the goal of combining traits into a single bacterium for upcoming preclinical testing in humans.