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Roche

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Trial drug aims to halt Alzheimer's before symptoms with monthly infusions
health4 days ago

Trial drug aims to halt Alzheimer's before symptoms with monthly infusions

A Roche-developed drug called trontinemab, a next-generation antibody given as monthly infusions, may remove brain plaques more effectively and could stop or prevent Alzheimer's before symptoms, with a landmark trial enrolling about 1,600 people aged 55+ at high risk and using blood biomarkers like p-tau217 to identify those most likely to benefit, while aiming to improve safety compared with earlier drugs such as lecanemab and donanemab.

via Daily Express|
#alzheimers#clinical-trial#dementia
Petrelintide Delivers Up to 10.7% Weight Loss in Zealand‑Roche Phase 2 Trial
biotech4 months ago

Petrelintide Delivers Up to 10.7% Weight Loss in Zealand‑Roche Phase 2 Trial

Zealand Pharma's Roche-partnered amylin analog petrelintide achieved statistically significant weight loss versus placebo in a 493-person phase 2 obesity trial (Zupreme-1), with up to 10.7% mean weight reduction at 42 weeks and a tolerable safety profile (no vomiting at the maximally effective dose; mild GI adverse events); the results support moving toward phase 3 (Zupreme-2) and related combination studies, though some analysts question its potential impact in a crowded obesity market, and the stock fell on the news.

via Fierce Biotech|
#biotech#obesity#petrelintide
AstraZeneca and Gilead Compete for Leadership in Triple-Negative Breast Cancer Treatments
healthcare9 months ago

AstraZeneca and Gilead Compete for Leadership in Triple-Negative Breast Cancer Treatments

Major pharmaceutical companies Gilead, AstraZeneca, and Roche reported promising new study results for cancer treatments, particularly in breast cancer, leading to stock price increases for Gilead and AstraZeneca, while Roche's shares declined slightly. The studies highlight advancements in drug efficacy and potential growth in the cancer drug market, with implications for future sales and industry competition.

via TipRanks|
#astrazeneca#breast-cancer#cancer
Roche Acquires Poseida for $1.5B, Boosting CAR-T Therapy Access
business1 year ago

Roche Acquires Poseida for $1.5B, Boosting CAR-T Therapy Access

Roche has agreed to acquire Poseida Therapeutics for $1.5 billion, integrating Poseida's CAR-T therapies and manufacturing capabilities into its Pharmaceuticals Division. The deal includes a tender offer for Poseida's shares at $9 each, with potential milestone payments. The acquisition, approved by both companies' boards, is expected to close in Q1 2025, enhancing Roche's cell therapy development in oncology, immunology, and neurology.

via Yahoo Finance|
#acquisition#business#car-t-therapies
Roche's Promising Weight Loss Pill Hits Eli Lilly, Novo Nordisk Shares
businesspharmaceuticals2 years ago

Roche's Promising Weight Loss Pill Hits Eli Lilly, Novo Nordisk Shares

Eli Lilly and Novo Nordisk stocks fell after Roche's Genentech unit reported positive early-stage data for its oral weight-loss drug, CT-996, which led to 6% weight loss in four weeks. This new development poses competition to Eli Lilly and Novo Nordisk's injectable treatments. Viking Therapeutics and Amgen, also developing oral weight-loss drugs, saw their stocks decline as well.

via Investor's Business Daily|
#businesspharmaceuticals#eli-lilly#novo-nordisk
"Roche's New Obesity Drug Shakes Up Market with Promising Trial Results"
business2 years ago

"Roche's New Obesity Drug Shakes Up Market with Promising Trial Results"

Shares of Novo Nordisk and Eli Lilly fell after Roche announced promising early-stage trial data for its new obesity drug candidate, CT-996, which showed significant weight loss in obese patients. Roche's shares rose, while other companies in the obesity treatment market, including Zealand Pharma, also saw declines. Roche's new drug could offer a competitive alternative to injectable treatments, though it may take years to become widely available.

via CNBC|
#business#eli-lilly#novo-nordisk
"FDA Advisory Committee Reviewing Alzheimer's Therapy Donanemab Amid Approval Delays and Treatment Battle"
health2 years ago

"FDA Advisory Committee Reviewing Alzheimer's Therapy Donanemab Amid Approval Delays and Treatment Battle"

Eli Lilly's Alzheimer's treatment, donanemab, faces setbacks as the FDA delays its approval decision and plans to hold an advisory committee meeting to discuss the drug. Competitors like Biogen and Roche are also making strides in Alzheimer's treatments, with a focus on under-the-skin shots and precision medicine. Despite the setbacks, experts believe it's an exciting time in the fight against Alzheimer's disease, with unprecedented diversity in Phase 3 clinical trials offering hope for more treatment options. However, challenges remain, including safety concerns and the need for more personalized approaches to treatment.

via Investor's Business Daily|
#alzheimers#biogen#eli-lilly
"Unveiling Final Fantasy 7 Rebirth: Characters, Features, and Updates"
gaming2 years ago

"Unveiling Final Fantasy 7 Rebirth: Characters, Features, and Updates"

The latest trailer for Final Fantasy 7 Rebirth confirms the return of Roche, a standout character from the Remake, hinting at a more expanded role for the elite SOLDIER forces and potentially adding new story elements for Rufus Shinra. The inclusion of Roche and other characters from the Remake trilogy in Rebirth reinforces the idea of a cohesive experience split into a trilogy, with the game set to release on February 29 for PlayStation 5.

via Inverse|
#final-fantasy-7#gaming#playstation-5
Roche's Acquisition of Carmot Signals Entry into Obesity Market, but Drugs Face Delay until 2030
pharmaceuticals2 years ago

Roche's Acquisition of Carmot Signals Entry into Obesity Market, but Drugs Face Delay until 2030

Swiss pharmaceutical company Roche is set to acquire anti-obesity drug developer Carmot Therapeutics for $2.7 billion in cash, with the potential for an additional $400 million based on milestones. Roche aims to challenge the dominance of Novo Nordisk and Eli Lilly in the global weight loss drugs market. However, the drugs developed by Carmot are still in the early stages, and Roche's CEO expects they may not be available until 2030 or later. The acquisition will provide Roche access to Carmot's research and development portfolio, including promising drug candidates such as CT-388, a once-weekly injection, and CT-996, a once-daily oral candidate. The obesity drugs market is estimated to be worth $200 billion in the next decade, attracting new entrants while established players struggle to meet demand.

via CNBC|
#carmot-therapeutics#drug-development#obesity-market
Roche's $3.1 Billion Acquisition of Carmot Positions It in the Obesity Drug Market
pharmaceuticals2 years ago

Roche's $3.1 Billion Acquisition of Carmot Positions It in the Obesity Drug Market

Swiss drugmaker Roche has agreed to acquire obesity drug developer Carmot Therapeutics for $2.7 billion upfront, joining the race to challenge weight-loss drug leaders Novo Nordisk and Eli Lilly. Carmot's lead drug candidate, a once-a-week injection called CT-388, is a dual GLP-1/GIP receptor agonist. Roche aims to develop CT-388 as the best obesity drug in the GLP-1 class, either alone or in combination with other compounds. The weight-loss market is estimated to reach $100 billion, and Roche's move signals its ambition to become a major player in this field.

via Reuters|
#carmot-therapeutics#glp-1-receptor-agonist#obesity-drugs
Roche's $3.1B Acquisition of Carmot Therapeutics Expands Obesity Drug Portfolio
business2 years ago

Roche's $3.1B Acquisition of Carmot Therapeutics Expands Obesity Drug Portfolio

Roche has agreed to acquire obesity-drug developer Carmot Therapeutics for up to $3.1 billion, gaining access to Carmot's portfolio of trial-stage GLP-1 agonists. The deal reflects the growing interest of top drugmakers in the booming market for weight-loss drugs, driven by the success of Novo Nordisk's Ozempic. Roche's acquisition aims to capitalize on the expanding market, which is projected to be worth $100 billion annually by 2030. The move comes as pharmaceutical companies race to develop GLP-1 agonists that can rival Novo Nordisk's blockbuster medicines. Roche's shares rose 2% following the announcement.

via MarketWatch|
#business#carmot-therapeutics#glp-1-agonists