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Universal Vaccine

All articles tagged with #universal vaccine

technology1 month ago•5 min saved

AI-designed universal coronavirus vaccine shows safety and immune response in first human trial

Researchers from Cambridge and Southampton used AI to design a ‘super-antigen’ vaccine intended to protect against multiple Sarbeco coronaviruses. In a Phase I trial, the vaccine was safe and elicited immune responses in 39 healthy volunteers when delivered via a needle-free micro-fluid jet, suggesting a potential future-proof solution against current and emerging coronaviruses, though larger and more diverse trials are needed and concerns about AI in medicine remain.

via Fox News|

#ai #clinical-trial #coronavirus

science1 month ago•47 min saved

AI-Designed Vaccine Targets Coronavirus Family, Early Trial Shows Promise

Researchers at the University of Cambridge used AI to design a DNA-based vaccine targeting immutable components of the sarbecovirus family (which includes SARS and SARS-CoV-2). In a small first-in-human trial with 39 participants, the AI-designed vaccine activated antibodies and was well tolerated across doses, suggesting potential for a universal coronavirus vaccine, though the durability and magnitude of protection require further study.

via Yahoo|

#ai-designed-vaccine #cambridge #coronaviruses

science1 month ago•3 min saved

AI-Designed DNA Vaccine Aims for Broad Coronavirus Protection

Cambridge researchers used a machine-learning model to design a DNA-based vaccine targeting the sarbecovirus family (SARS, COVID and related viruses), creating a “super-antigen” and conducting the first human trial of an AI-designed vaccine. In a 39-person study, the vaccine activated virus-fighting antibodies and was well tolerated across four doses, but the immune response was modest and durability is unknown. If successful, the approach could provide broad protection against current and future coronavirus mutations, with the benefits of stability and needle-free administration, though more research is needed.

via Futurism|

#artificial-intelligence #biotechnology #clinical-trial

science1 month ago•5 min saved

AI-crafted universal coronavirus vaccine clears first-in-human trial

Cambridge researchers and DIOSynVax report the first-in-human trial of an AI-designed 'super-antigen' universal coronavirus vaccine. The DNA vaccine, created entirely by computer simulations and delivered via a needle-free micro‑jet system, was safe in 39 volunteers and elicited immune responses against SARS-CoV-2, SARS, and related bat coronaviruses, suggesting broad protection beyond current strains. A Phase 2 study is planned to confirm wider protection, with the approach potentially adaptable to other virus families.

via ScienceDaily|

#ai #clinical-trial #coronavirus

science1 month ago•3 min saved

AI-Crafted Universal Coronavirus Vaccine Clears Phase I Trial

Researchers at Cambridge used AI to design a pan-coronavirus vaccine, pEVAC-PS, which in a Phase I trial in 39 healthy volunteers appeared safe and elicited cross-reactive immune responses to multiple sarbecoviruses; the team plans Phase II trials and has spun off DIOSynVax to commercialize the AI platform for universal vaccines against threats like flu and Ebola.

via Gizmodo|

#artificial-intelligence #coronaviruses #phase-i-trial

health3 months ago•71 min saved

Researchers chase a universal respiratory vaccine, but it's still years away

A nasal-spray vaccine tested in mice stimulates the lungs’ innate immune system to mount broad protection against multiple respiratory pathogens, including viruses, bacteria and even allergens. While the approach shows proof-of-concept for wider protection, experts caution it is far from a universal vaccine for humans and will require extensive clinical trials to assess safety, durability and effectiveness across diverse populations.

via Live Science|

#health #innate-immunity #nasal-spray

science4 months ago•4 min saved

Nasal universal vaccine shields mice from viruses, bacteria, and allergies

A nasal spray vaccine, GLA-3M-052-LS+OVA, protected mice against SARS-CoV-2 and other coronaviruses, guarded against certain bacteria, and reduced allergy-related lung symptoms, by engaging both innate and adaptive immunity; with three doses, it lowered lung viral loads and sped up immune responses, and human trials could begin with a target availability in 5–7 years if results translate to people.

via ScienceAlert|

#adaptive-immunity #innate-immunity #nasal-spray

health4 months ago•17 min saved

Chasing a universal flu vaccine: hitting the virus where it stays the same

Scientists are pursuing a universal flu vaccine that would protect against many influenza strains by targeting conserved parts of the virus; multiple candidates are in trials using approaches such as focusing the immune response on the virus's stable cone of haemagglutinin, exposing fixed regions by presenting thousands of HA variations, blocking neuraminidase, stimulating T cells, or nasal delivery, and some work also explores AI-assisted strain selection. While a true universal vaccine may take years, interim gains include more durable protection and higher-dose shots for older adults, with experts optimistic about improvements within about five to ten years.

via BBC|

#artificial-intelligence #haemagglutinin #health

science4 months ago•12 min saved

Nasal universal vaccine shows cross-protection against cold, flu, and COVID in mice

A nasal vaccine candidate that trains frontline lung immunity shows promise in mice for broad protection against multiple respiratory infections (cold viruses, flu, and COVID) by boosting alveolar macrophages and T cells rather than targeting a single pathogen; it may also dampen allergic reactions. Human safety and efficacy remain unproven, and the best-case path to a human-ready vaccine is five to seven years, with protection in mice lasting up to about three months and many unknowns, including effects in older adults and on DNA viruses.

via The Conversation|

#alveolar-macrophages #mucosal-immunity #nasal-spray

health-and-medicine4 months ago•10 min saved

Researchers Unveil Universal Nasal Spray Vaccine Targeting Viruses, Bacteria, and Allergens

Stanford Medicine researchers have developed a nasal spray vaccine that activates the lungs’ innate immune system to provide months-long protection against a broad range of respiratory threats—including SARS-CoV-2, other coronaviruses, bacterial pneumonia pathogens, and even house dust mite allergens—in mice. If safety and efficacy are shown in humans, the approach could reduce the need for multiple yearly vaccines and idea of rapid protection during outbreaks, with Phase I trials moving forward and an estimated 5–7 years before potential availability.

via ScienceDaily|

#health-and-medicine #innate-immunity #nasal-spray

science5 months ago•6 min saved

Nasal universal vaccine boosts innate immunity to shield mice from multiple respiratory pathogens

A Stanford-led study describes an intranasal “universal vaccine” that activates the innate immune system to provide at least three months of protection in mice against SARS-CoV-2, other coronaviruses, and bacteria causing respiratory infections, while also dampening allergic responses. If safe and effective in humans, it could become a winter-wide first line of defense against diverse respiratory diseases.

via Nature|

#innate-immunity #mucosal-vaccination #respiratory-allergies

science5 months ago•9 min saved

Mice study hints at nasal vaccine for universal respiratory protection

Stanford Medicine researchers report an intranasal vaccine that activates innate and adaptive immunity to provide months-long protection in mice against a broad spectrum of respiratory threats—SARS-CoV-2 and other coronaviruses, Staphylococcus aureus, Acinetobacter baumannii, and house dust mite allergen—suggesting a path toward a universal respiratory vaccine, with human safety trials planned next.

via Stanford Medicine|

#innate-immunity #intranasal-vaccine #mouse-model

health10 months ago•3 min saved

Universal Cancer Vaccine Effectively Eliminates Resistant Tumors in Mice

Researchers at the University of Florida have developed a promising universal cancer vaccine using mRNA technology that stimulates the immune system to attack various tumors, especially when combined with immune checkpoint inhibitors, showing strong results in mice and paving the way for future human trials.

via ScienceAlert|

#cancer-vaccine #clinical-trials #health

healthcare1 year ago•5 min saved

Advances in Cancer Vaccines and mRNA Therapeutics Show Promising Breakthroughs

Researchers at the University of Florida have developed a promising experimental mRNA-based vaccine that could lead to a universal cancer vaccine, boosting the immune system to fight various cancers and potentially replacing traditional treatments like surgery and chemotherapy. The vaccine works by stimulating immune responses, including increasing PD-L1 proteins on cancer cells, making tumors more vulnerable to immune attack. While still in early stages and tested in mice, this approach could revolutionize cancer treatment if successful in humans.

via CNBC|

#cancer-research #cancer-vaccine #healthcare

health1 year ago•4 min saved

UF Researchers Develop Revolutionary mRNA Vaccine for Universal Cancer Treatment

A study shows that a generalized mRNA vaccine can boost the immune response against various tumors in mice, especially when combined with immunotherapy drugs, suggesting a potential pathway toward a universal cancer vaccine that activates the immune system broadly rather than targeting specific cancer types.

via Medical Xpress|

#cancer #health #immunotherapy