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Liraglutide

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GLP-1 Diabetes Drugs Target Alzheimer’s Pathology in Animal Studies
science1 month ago

GLP-1 Diabetes Drugs Target Alzheimer’s Pathology in Animal Studies

A systematic review of 30 preclinical studies finds GLP-1 receptor agonists (liraglutide, semaglutide, exenatide, dulaglutide) consistently reduce Alzheimer's hallmarks amyloid-beta plaques and tau tangles in animal and cell models, with liraglutide showing the strongest and most consistent effects; human data are limited and mixed so far, though some trials show preserved brain glucose metabolism and inflammatory marker changes, suggesting these drugs may help prevent dementia if used earlier rather than cure established disease.

via Neuroscience News|
#alzheimers-disease#amyloid-beta#glp-1-receptor-agonists
GLP-1 diabetes meds may curb worsening anxiety and depression, study finds
health2 months ago

GLP-1 diabetes meds may curb worsening anxiety and depression, study finds

A large Swedish study of about 95,000 people with depression or anxiety who were taking diabetes medications found that GLP-1 receptor agonists—especially semaglutide and liraglutide—were associated with a lower risk of worsening mental health outcomes such as hospitalizations, sick leave, self-harm, or death, while other GLP-1 drugs did not show the same benefit; experts caution about drawing causality from observational data. A separate Danish study linked first-trimester exposure to semaglutide or liraglutide for diabetes with a higher risk of preterm birth.

via The Guardian|
#anxiety#depression#glp-1-receptor-agonists
"Maintaining Weight Loss After Ozempic: The Role of Exercise and Post-Treatment Analysis"
health-and-medicine2 years ago

"Maintaining Weight Loss After Ozempic: The Role of Exercise and Post-Treatment Analysis"

A study from the University of Copenhagen suggests that combining liraglutide injections with a supervised exercise program helps patients maintain weight loss better after stopping the drugs. The study compared body weight changes after exercise, pharmaceutical interventions, or both treatments combined. It found that while liraglutide can result in weight loss comparable to exercise on its own, exercise is more effective at maintaining weight loss in the long run. Participants who combined liraglutide with supervised exercise were able to sustain a weight loss of at least 10 percent of their initial weight a year after stopping treatment, showing better outcomes than those in the exercise-only group. The study highlights the importance of exercise in maintaining weight loss and suggests that more research is needed to explore how weight-loss drugs like liraglutide can be used most effectively for long-term weight maintenance.

via ScienceAlert|
#exercise#health-and-medicine#liraglutide
"Weight-Loss Drug Reduces Opioid Cravings: A Surprising Connection"
health2 years ago

"Weight-Loss Drug Reduces Opioid Cravings: A Surprising Connection"

A small study presented at the American Association for the Advancement of Science conference found that the anti-obesity drug liraglutide significantly reduced opioid cravings in patients with opioid use disorder. The study, funded by the National Institute of Drug Abuse and pharma company Novo Nordisk, showed a 30% reduction in cravings over a three-week period, with potential for an additive effect when combined with buprenorphine. While the drug was found to be safe, gastrointestinal distress led to a high drop-out rate, suggesting the need for further investigation. Despite limitations, the findings suggest liraglutide could be a promising adjunct to existing treatments for opioid addiction.

via STAT|
#anti-obesity-drug#clinical-trial#health
GLP-1 Drugs Aid Weight Loss Post-Bariatric Surgery
health2 years ago

GLP-1 Drugs Aid Weight Loss Post-Bariatric Surgery

A new study has found that GLP-1 drugs, such as liraglutide, can help people who have undergone bariatric surgery but did not achieve their weight loss goals. These drugs suppress appetite and improve glucose, cholesterol, and blood pressure levels, contributing to weight loss. The study showed that taking liraglutide led to significant reductions in body fat and weight, as well as positive changes in other health markers. GLP-1 drugs act on the same mechanisms as bariatric surgery and can be used to optimize surgery outcomes.

via Healthline|
#bariatric-surgery#glp-1-drugs#health
"WHO to Evaluate Inclusion of Obesity Medication in Essential Medicines List"
health3 years ago

"WHO to Evaluate Inclusion of Obesity Medication in Essential Medicines List"

Advisers to the World Health Organization will consider adding liraglutide, the active ingredient in certain diabetes and obesity medications, to its list of essential medicines. The drug mimics the effects of an appetite-regulating hormone and stimulates the release of insulin, helping to lower blood sugar and slow the passage of food through the gut. The request to add GLP-1 receptor agonists such as liraglutide came from four researchers at US institutions. WHO’s advisers will make recommendations on which drugs should be included in this year’s list, expected to come in September.

via CNN|
#essential-medicines-list#health#liraglutide