Tag

Neurodevelopment

All articles tagged with #neurodevelopment

science5 days ago•9 min saved

Early-Development ZNF804A Linked to Hyper-Excitable Neurons in Schizophrenia

A precision functional genomics study shows the schizophrenia risk gene ZNF804A is most active in glutamatergic neurons during the second trimester. Using CRISPR-Cas9 to suppress ZNF804A in developing neurons increased local protein translation at dendritic tips, raised synapse density, and heightened electrical excitability, linking this genetic risk factor to a specific neurodevelopmental mechanism that may contribute to schizophrenia.

via Neuroscience News|

#crispr #neurodevelopment #schizophrenia

science1 month ago•7 min saved

Valproic Acid Triggers Embryonic Cell Senescence, Explaining Birth Defects and Autism Risk

Researchers using mice and human organoids show valproic acid (VPA) can force developing neuroepithelial cells to enter senescence via the p19Arf pathway, shrinking the neural progenitor pool and causing defects such as microcephaly and neural tube problems; removing p19Arf in mice reduces some VPA-related effects, including autism-linked gene changes, but other abnormalities persist, indicating multiple developmental pathways are disrupted and highlighting a potential link between misregulated senescence and birth defects and autism risk.

via SciTechDaily|

#autism #birth-defects #cellular-senescence

health-and-medicine1 month ago•7 min saved

Autism traits shape brain networks shared by ASD and ADHD

A Molecular Psychiatry study shows that the severity of autism-like symptoms, not the diagnostic label, is linked to specific brain connectivity patterns and gene activity shared by autism and ADHD, suggesting a common biology and supporting a dimensional, biomarker-informed approach to neurodevelopmental conditions.

via ScienceDaily|

#adhd #autism #brain-imaging

science4 months ago•12 min saved

Sperm RNA Clock Reveals Mid-Life Aging Cliff Linked to Child Health

A new EMBO Journal study reports a mid-life, abrupt shift in sperm RNA—an “aging cliff”—that could influence what fathers pass to their offspring, offering a mechanism beyond DNA mutations that may help explain increased risks of neurodevelopmental and metabolic issues in children of older dads and supporting aging-related cautions in assisted reproduction.

via ZME Science|

#aging #neurodevelopment #paternalage

science4 months ago•5 min saved

Brains Build, Not Break: Development Extends into the 30s, Not a 25-Year Cutoff

New neuroscience shows brain maturation continues into the early 30s as neural networks become more efficient; the classic 'finish at 25' myth arose from earlier gray-matter studies and datasets ending around age 20, but latest research on white matter reveals ongoing segregation and integration until about 32. There is no magic switch at 25—adulthood is a prolonged construction zone, and you can support brain health through aerobic exercise, learning new skills, and cognitively challenging activities while minimizing chronic stress.

via SciTechDaily|

#adolescence #adulthood #brain-networks

health4 months ago•5 min saved

Lancet Review Finds No Link Between Tylenol in Pregnancy and Autism

A rigorous Lancet review of 43 studies found no association between acetaminophen (Tylenol) use during pregnancy and autism, ADHD, or intellectual disability, supporting Tylenol as a safe first-line treatment for pain/fever in pregnancy and countering earlier warnings tied to Trump-era statements. The analysis used strict study selection, quality assessment, and sibling comparison studies to rule out bias, though some experts noted previous conflicting findings and ongoing debates about confounding factors.

via NBC News|

#acetaminophen #autism #health

science4 months ago•4 min saved

The Gut-Brain Connection: How Microbes Influence Mood and Brain Function

New research indicates that gut microbes influence brain function and evolution, with experiments showing that transferring microbes from primates with different brain sizes to mice alters brain activity and gene expression, potentially impacting cognitive traits and mental health conditions.

via SciTechDaily|

#brain-function #gut-microbiome #mental-health

science4 months ago•3 min saved

Gut Microbes: The Hidden Link to Human Intelligence and Brain Evolution

A study from Northwestern University demonstrates that gut microbes from primates with different brain sizes can influence brain activity and gene expression in mice, suggesting a significant role of the microbiome in brain evolution and potential links to neurodevelopmental disorders like autism and ADHD.

via ScienceDaily|

#brain-evolution #gut-microbiome #microbiome-and-behavior

health5 months ago•5 min saved

Triple Supplement Blend Enhances Social Behavior in Autism Mouse Model

A mouse study suggests that a combination of zinc, serine, and branched-chain amino acids may improve brain connectivity and social behaviors in models of autism spectrum disorder, though further research is needed before clinical application.

via Medical News Today|

#autism #brain-connectivity #health

health6 months ago•3 min saved

Shared Brain-Gene Signatures Link Autism and ADHD Severity in Children

A study finds that autism symptom severity in children with autism and ADHD is linked to shared patterns of brain connectivity and gene expression, regardless of diagnosis, suggesting a common biological basis and supporting dimensional models of neurodevelopmental conditions.

via Medical Xpress|

#adhd #autism #brain-connectivity

health6 months ago•5 min saved

Shared Brain-Gene Patterns Link Autism and ADHD Severity in Children

A study finds that autism symptom severity, regardless of diagnosis, correlates with shared brain connectivity patterns and gene expression profiles in children with autism or ADHD, supporting a dimensional and biological approach to understanding neurodevelopmental conditions.

via Neuroscience News|

#adhd #autism #brain-connectivity

health6 months ago•3 min saved

Study Links COVID-19 During Pregnancy to Increased Autism Risk in Children

A study suggests children born to mothers who had Covid-19 during pregnancy are at higher risk of autism and neurodevelopmental disorders, especially if the infection occurred in the third trimester, highlighting potential impacts of maternal Covid-19 on fetal brain development.

via Yahoo|

#autism #covid-19 #fetal-brain

science7 months ago•5 min saved

Scientists Identify Biological Marker Differentiating Psychopaths from Normals

Scientists have discovered that psychopaths have a 10% larger striatum in the brain, which is linked to impulsivity and a craving for stimulation, providing insights into the neurobiological basis of antisocial behavior and its developmental roots.

via SciTechDaily|

#brain-structure #mri-scans #neurodevelopment

health-and-neuroscience7 months ago•3 min saved

Early Neglect and Its Impact on Brain Development

Research on mice shows that even mild early-life neglect, such as limited nesting material, impairs maternal care, leading to increased stress hormones, growth delays, and attachment issues in pups, highlighting the importance of consistent, adequate caregiving for healthy emotional and physiological development.

via Neuroscience News|

#attachment-deficits #early-childhood-adversity #health-and-neuroscience

health7 months ago•4 min saved

Postpartum Risks of Psilocybin Use

A UC Davis study found that psilocybin worsens anxiety and depression symptoms in postpartum mice and can negatively affect their offspring, suggesting that psychedelics may pose risks during the postpartum period and are not universally beneficial for mental health treatment.

via UC Davis|

#animal-study #health #mental-health