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Neurodevelopment

All articles tagged with #neurodevelopment

Genetics link infant temperament to later behavior across diverse populations
science9 days ago

Genetics link infant temperament to later behavior across diverse populations

This GWAS meta-analysis across European and multi-ancestry cohorts (up to ~78k infants) identifies ten loci associated with four temperament traits in the first three years: emotionality, activity, shyness, and sociability. SNP heritability ranges from ~3% to ~15%, two loci colocalize with adult cortex eQTLs (RHEBL1 and MR1), and genetic correlations link early temperament to adult neuroticism, ADHD, autism and extraversion. Findings replicate across ancestry groups, and polygenic scores explain modest variance, with within-family analyses supporting genetic influences on temperament.

via Nature|
#genetics#gwas#infancy
Maternal heart health linked to child development; low heart health raises delay risk by 62%
health18 days ago

Maternal heart health linked to child development; low heart health raises delay risk by 62%

A study of over 8,000 mothers finds that poorer cardiovascular health is associated with higher rates of developmental delays in children by age 4 (8.8% delays for high‑cardiovascular-health moms vs 16.8% for low‑health moms), a 62% increased risk. Delays affected communication, motor, and social skills. Experts urge improving heart health before and during pregnancy through diet (Mediterranean), regular exercise, adequate sleep, and avoiding smoking to potentially improve lifelong outcomes for both mother and child.

via nypost.com|
#child-development#health#heart-health
Common plastic additive may rewire the brain, triggering lifelong anxiety in rats
health-and-medicine22 days ago

Common plastic additive may rewire the brain, triggering lifelong anxiety in rats

A study presented at ENDO 2026 reports that early-life exposure to the plasticizer DEHP increases anxiety-like behavior in adult male rats; exposure before and after birth led to less exploration and more freezing, and these effects were reversed by GABA agonists or testosterone, suggesting potential implications for human neurodevelopment and endocrine disruption.

via ScienceDaily|
#anxiety#dehp#endocrine-disrupting-chemicals
Early-Development ZNF804A Linked to Hyper-Excitable Neurons in Schizophrenia
science1 month ago

Early-Development ZNF804A Linked to Hyper-Excitable Neurons in Schizophrenia

A precision functional genomics study shows the schizophrenia risk gene ZNF804A is most active in glutamatergic neurons during the second trimester. Using CRISPR-Cas9 to suppress ZNF804A in developing neurons increased local protein translation at dendritic tips, raised synapse density, and heightened electrical excitability, linking this genetic risk factor to a specific neurodevelopmental mechanism that may contribute to schizophrenia.

via Neuroscience News|
#crispr#neurodevelopment#schizophrenia
Valproic Acid Triggers Embryonic Cell Senescence, Explaining Birth Defects and Autism Risk
science2 months ago

Valproic Acid Triggers Embryonic Cell Senescence, Explaining Birth Defects and Autism Risk

Researchers using mice and human organoids show valproic acid (VPA) can force developing neuroepithelial cells to enter senescence via the p19Arf pathway, shrinking the neural progenitor pool and causing defects such as microcephaly and neural tube problems; removing p19Arf in mice reduces some VPA-related effects, including autism-linked gene changes, but other abnormalities persist, indicating multiple developmental pathways are disrupted and highlighting a potential link between misregulated senescence and birth defects and autism risk.

via SciTechDaily|
#autism#birth-defects#cellular-senescence
Sperm RNA Clock Reveals Mid-Life Aging Cliff Linked to Child Health
science5 months ago

Sperm RNA Clock Reveals Mid-Life Aging Cliff Linked to Child Health

A new EMBO Journal study reports a mid-life, abrupt shift in sperm RNA—an “aging cliff”—that could influence what fathers pass to their offspring, offering a mechanism beyond DNA mutations that may help explain increased risks of neurodevelopmental and metabolic issues in children of older dads and supporting aging-related cautions in assisted reproduction.

via ZME Science|
#aging#neurodevelopment#paternalage
Brains Build, Not Break: Development Extends into the 30s, Not a 25-Year Cutoff
science5 months ago

Brains Build, Not Break: Development Extends into the 30s, Not a 25-Year Cutoff

New neuroscience shows brain maturation continues into the early 30s as neural networks become more efficient; the classic 'finish at 25' myth arose from earlier gray-matter studies and datasets ending around age 20, but latest research on white matter reveals ongoing segregation and integration until about 32. There is no magic switch at 25—adulthood is a prolonged construction zone, and you can support brain health through aerobic exercise, learning new skills, and cognitively challenging activities while minimizing chronic stress.

via SciTechDaily|
#adolescence#adulthood#brain-networks
Lancet Review Finds No Link Between Tylenol in Pregnancy and Autism
health5 months ago

Lancet Review Finds No Link Between Tylenol in Pregnancy and Autism

A rigorous Lancet review of 43 studies found no association between acetaminophen (Tylenol) use during pregnancy and autism, ADHD, or intellectual disability, supporting Tylenol as a safe first-line treatment for pain/fever in pregnancy and countering earlier warnings tied to Trump-era statements. The analysis used strict study selection, quality assessment, and sibling comparison studies to rule out bias, though some experts noted previous conflicting findings and ongoing debates about confounding factors.

via NBC News|
#acetaminophen#autism#health