Tag

Organ On A Chip

All articles tagged with #organ on a chip

technology8 days ago•55 min saved

Colon-on-a-chip uncovers stromal drivers, hormonal influences, and cancer risk in IBD

A colon-on-a-chip platform using patient-derived epithelium and fibroblasts reproduces healthy and IBD-like tissue, showing IBD fibroblasts drive barrier dysfunction, mucus changes, and inflammation. Peristalsis-like mechanical cues amplify fibrosis and inflammatory signaling in IBD chips, while female hormones exacerbate fibrosis and inflammation specifically in IBD tissues. Tissue-recombinant experiments confirm the stroma as the key driver of barrier breach and cytokine production. When exposed to the carcinogen ENU, IBD chips exhibit greater inflammation, loss of E-cadherin, nuclear β-catenin, and early cancer markers, along with copy-number changes, indicating heightened cancer-initiation risk. The model enables patient-specific studies and tests of stromal-focused therapies and sex-hormone effects on disease progression and cancer risk.

via Nature|

#cancer-progression #fibrosis #inflammatory-bowel-disease

space1 month ago•15 min saved

Chips carrying Artemis II astronauts’ cells map spaceflight’s effect on human biology

During Artemis II’s lunar flyby, four tiny chips seeded with the astronauts’ bone marrow cells circled the Moon to study how deep-space conditions—like radiation and microgravity—affect human biology, part of NASA’s Avatar program using organ-on-a-chip devices to inform future space medicine.

via The Washington Post|

#artemis-ii #bone-marrow #organ-on-a-chip

science1 month ago•8 min saved

Artemis II readies crewed lunar flyby with cutting-edge biology experiments

NASA's Artemis II will launch four astronauts on a roughly ten-day lunar flyby to test spacecraft systems for future lunar landings and advance science in deep space. The crew will study how deep-space travel affects health, monitor radiation exposure with cabin sensors, collect biological samples, and use an organ-on-a-chip experiment built from each astronaut's blood cells to probe DNA damage and telomere changes, while observing lunar terrain never seen up close and training for a sustainable human presence on the Moon.

via Nature|

#artemis-ii #deep-space-radiation #moon

science6 months ago•4 min saved

UK Announces Strategy to End Animal Testing and Boost AI Alternatives

The UK government has announced plans to phase out animal testing for safety assessments by the end of 2025, replacing many tests with human cell-based and computer simulation methods, aiming to significantly reduce animal use in scientific research by 2030, while acknowledging the challenges and limitations of non-animal models.

via BBC|

#alternatives-to-animal-experiments #animal-testing #government-plan

science7 months ago•5 min saved

Embry-Riddle SPACE Lab Advances Space and Earth Health Research

NASA's AVATAR project involves creating miniature tissue chips from astronauts' cells to study space hazards and develop personalized countermeasures, potentially revolutionizing space travel and medicine on Earth.

via ScienceAlert|

#avatar-project #deep-space-exploration #nasa

science8 months ago•5 min saved

NASA to Send Human Cells on Microchips to the Moon for Space Research

NASA is deploying tiny lab devices called organ chips with human cells aboard Artemis II to study how space affects human biology, focusing initially on bone marrow, to improve health protections for astronauts on lunar and Mars missions. These chips will help personalize medical care, predict responses to space radiation, and enhance safety during long-duration space travel.

via Earth.com|

#astronaut-health #deep-space-radiation #nasa

science8 months ago•5 min saved

Artemis II Crew to Use Avatars for Deep Space Health Research

NASA's Artemis II mission will carry the AVATAR experiment, using organ-on-a-chip devices containing astronaut cells to study the effects of deep space radiation and microgravity on human health, aiming to improve astronaut protection and advance personalized medicine.

via NASA Science (.gov)|

#artemis-ii #nasa #organ-on-a-chip

science-and-technology2 years ago•4 min saved

"Revolutionary 'Heart-on-a-Chip' Unveiled by Scientists"

Scientists have developed a new "heart-on-a-chip" device the size of a credit card, mimicking human heart biology to study heart disease and aid drug discovery. This technology, part of the organ-on-a-chip systems, aims to revolutionize drug development by providing more accurate ways to mimic human organs in the lab, potentially reducing or replacing animal testing. While further refinement is needed, these models have the potential to shift the way new drugs are developed and tested, as recognized by the FDA.

via Livescience.com|

#drug-development #heart-disease #heart-on-a-chip