Tag

Pain

All articles tagged with #pain

health1 month ago•67 min saved

Immune signals and hormones may explain why women's pain lingers longer

New research combining mouse experiments with human vehicle‑crash data suggests that pain after injury lasts longer in women because monocytes produce less IL-10, a molecule that both reduces inflammation and directly dampens pain signals; testosterone boosts IL-10 production in male monocytes, helping men recover faster. This shifts the view of the immune system from solely driving pain to also helping resolve it, pointing to therapies that enhance the body's natural pain‑resolution pathways to prevent chronic pain.

via Live Science|

#health #immune-system #interleukin-10

health1 month ago•24 min saved

Immune ‘Off-Switch’ for Pain Found to Differ by Sex, Study Shows

A new Science Immunology study links IL-10–producing monocytes to an immune brake that dampens pain after injury. In mice, males had more IL-10–producing cells and recovered faster, with pain lasting longer when IL-10 or its receptor was blocked. Human data from the AURORA trauma study showed higher IL-10 levels at injury in men and lower subsequent pain, suggesting a biological basis for women’s longer-lasting pain. While not the sole pathway for all chronic pain, the findings point to immune signaling as a potential target, with ideas like skin-applied testosterone to modulate IL-10–positive monocytes under exploration (noting more research is needed).

via ZME Science|

#health #il-10 #immune-system

health1 month ago•3 min saved

Immune cells and hormones may explain why women's pain lasts longer

New research in mice and humans suggests that immune cells produce IL-10 to help resolve pain, and sex differences in this response—shaped by testosterone—may explain why women often recover more slowly from injury and have a higher risk of chronic pain. These findings point to therapies that boost the body's natural pain-resolution system rather than only blocking pain signals.

via The Conversation|

#gender-differences #health #il-10

health2 months ago•55 min saved

Stem-cell derived 'pain sponge' targets pain at the source in arthritis

Researchers engineered human pluripotent stem cell–derived sensory neurons that act as a biological "pain sponge," soaking up inflammatory pain signals at the site of inflammation in mice with osteoarthritis and also promoting bone and cartilage repair. The SN101 approach is in preclinical stages, with safety, immune response and translation to humans unresolved and no peer‑reviewed human data yet.

via Live Science|

#health #neuroscience #osteoarthritis

science2 months ago•8 min saved

Gene Therapy Targets Pain Circuits to Relieve Chronic Pain Without Addiction

A preclinical CNS-targeted gene therapy dampens pain signals in specific brain circuits to relieve chronic pain while avoiding the brain reward pathways tied to addiction, using AI-guided imaging and animal models, with an off switch for long-lasting relief and moving toward clinical trials to help the roughly 50 million Americans affected by chronic pain.

via SciTechDaily|

#addiction #gene-therapy #neuroscience

health5 months ago•5 min saved

Scientists May Have Unraveled the Mystery of Fibromyalgia Pain

A large genetic study has identified 26 genetic regions linked to fibromyalgia, revealing that the condition primarily originates in the brain's neural circuits that control pain sensitivity, rather than in muscles or joints. The findings suggest fibromyalgia is related to nervous system hypersensitivity and shares genetic links with other disorders like chronic fatigue and PTSD, offering new avenues for early detection and targeted treatments.

via Earth.com|

#brain #fibromyalgia #genetics

neuroscience6 months ago•106 min saved

Brainstem Circuits as Key Regulators of Chronic Pain and Need-State Control

The study identifies Y1 receptor-expressing neurons in the lateral parabrachial nucleus as key modulators of long-term pain, showing that their activity correlates with persistent pain states and can be suppressed by need states like hunger and thirst through NPY signaling, which gates nociceptive input to promote survival.

via Nature|

#brain-circuits #chronic-pain #neuroscience

health-and-medicine7 months ago•7 min saved

Sanjay Gupta Reveals How Pain Is Managed by the Brain

Sanjay Gupta discusses the nature of pain, how the brain processes it, and methods to manage and reduce pain through natural and medical means, emphasizing that pain doesn't always have to hurt and can be influenced by mental training and understanding of the body's systems.

via NPR|

#endogenous-opioids #health-and-medicine #inflammation

health7 months ago•0 min saved

Recognizing Hidden Heart Attack Signs: Fatigue and Declining Stamina

The article discusses unexpected signs of a heart attack, illustrated by Lindsay Shanks' experience of sharp pain, tingling hands, and nausea while she was sleeping, highlighting the importance of recognizing atypical symptoms.

via The Washington Post|

#health #heart-attack #lindsay-shanks

health7 months ago•9 min saved

Dr. Sanjay Gupta Explores Brain-Based Solutions for Chronic Pain Relief

Dr. Sanjay Gupta explores the nature of pain, emphasizing that all pain is processed in the brain and can be managed through various treatments beyond opioids, including nerve blocks, virtual reality, and meditation, offering hope for those suffering from chronic pain.

via CNN|

#brain #chronic-pain #health

health8 months ago•5 min saved

Reddit Insights: Men’s Experiences with Vasectomy Pain and Regret

A study analyzing Reddit posts reveals that many men experience fear, regret, and persistent pain after vasectomy, challenging the perception of it being a largely risk-free procedure. The findings highlight the importance of transparent, nuanced communication about potential long-term outcomes to ensure truly informed consent, especially as online discussions increasingly influence health decisions.

via The Conversation|

#health #health-communication #online-forums

health8 months ago•4 min saved

Old Injuries Cause Lasting Changes in Brain's Fear and Pain Response

A study shows that past injuries can cause long-term hypersensitivity to fear and pain by involving stress hormones and the TRPA1 receptor, which may explain chronic pain and trauma-related disorders. The research highlights that fear and pain, while related, are driven by different biological pathways, offering potential targets for treatment.

via Neuroscience News|

#brain #fear #health

health8 months ago•5 min saved

Research Links Sound-Induced Stress to Increased Pain and Inflammation

Research shows that ultrasonic vocalizations emitted by mice in pain can trigger hyperalgesia and brain inflammation in nearby mice, even without direct injury, highlighting how environmental and emotional stressors like stressful sounds can worsen pain and interfere with treatment in humans.

via Neuroscience News|

#health #inflammation #mouse-study

health9 months ago•5 min saved

New Brain Circuit Links Pain to Emotional Suffering and Fear

Researchers at the Salk Institute identified a new brain circuit involving CGRP neurons in the thalamus that mediates the emotional aspect of pain, challenging traditional views and offering potential new treatments for chronic pain and related psychiatric conditions like PTSD and migraines.

via ScienceDaily|

#brain-circuit #fibromyalgia #health

science2 years ago•14 min saved

"Deciphering Neural Circuits: Unraveling the Choice Between Pleasure and Pain"

Ishmail Abdus-Saboor, a neuroscientist at Columbia University, is leading research into the perception of pleasurable and painful touches, aiming to understand how the brain determines whether a touch to the skin is painful or pleasurable. His work has led to insights into the neural circuits that govern pleasure and pain in animals, as well as the development of new measurement tools for quantifying pain and pleasure in lab animals. Abdus-Saboor's research also explores the potential medical implications of targeting the skin for therapeutic purposes and the study of touch in naked mole rats. Throughout his career, he has faced challenges but encourages aspiring scientists, especially those from underrepresented backgrounds, to pursue their passion and not to be discouraged by obstacles.

via Quanta Magazine|

#neuroscience #pain #pleasure