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Psoriasis

All articles tagged with #psoriasis

Oruka's ORKA-001 Sparks Hopes for a Category-Winning Psoriasis Drug
business1 month ago

Oruka's ORKA-001 Sparks Hopes for a Category-Winning Psoriasis Drug

Oruka Therapeutics reports phase 2a results for ORKA-001, a long-acting IL-23 inhibitor for plaque psoriasis, showing 63.5% of treated patients achieving complete skin clearance (40/63) at week 16 versus 1/21 on placebo, with a clean safety profile and potential for annual dosing. Jefferies analysts say the data could outperform Skyrizi and support $5–$10 billion in sales, helping the stock rise about 30% as the company moves to phase 3 with an active comparator.

via Fierce Biotech|
#business#il-23-inhibitor#orka-001
Keratin 16 acts as a brake on skin inflammation, hinting at new psoriasis therapies
health1 month ago

Keratin 16 acts as a brake on skin inflammation, hinting at new psoriasis therapies

A new study finds keratin 16 normally suppresses skin inflammation by dampening type I interferon signaling; when KRT16 is mutated or absent, inflammation spikes, linking keratin 16 to conditions like pachyonychia congenita, psoriasis, and eczema. The researchers suggest targeting interferon signaling could yield new treatments, as an interferon inhibitor reduced skin lesions in a mouse PC model.

via Live Science|
#health#immune-system#inflammation
From Shame to Clear Skin: A Psoriasis Patient’s Breakthrough Trial
health2 months ago

From Shame to Clear Skin: A Psoriasis Patient’s Breakthrough Trial

A 47-year-old woman, Amber Dean, suffered years of physical and emotional torment from plaque psoriasis, enduring misdiagnoses and failed treatments until she joined a clinical trial for ICOTYDE, the first oral medication for the condition. She now reports full skin clearance and a renewed sense of self, calling the decision one of her best health choices and urging others not to be defined by the disease.

via Yahoo News Canada|
#amber-dean#clinical-trial#health
J&J’s new psoriasis pill could reshape the treatment landscape
healthcare2 months ago

J&J’s new psoriasis pill could reshape the treatment landscape

Johnson & Johnson won U.S. approval for Icotyde, a daily oral medication for moderate-to-severe plaque psoriasis in patients 12 and older, designed to mimic the effects of top-selling injectables like Skyrizi and Tremfya without injections. The pill could expand the patient market and is projected to reach more than $5 billion in peak annual sales, potentially reshaping competition in a multibillion-dollar field.

via statnews.com|
#fda-approval#healthcare#icotyde
Skin Immune Cells Trigger Hidden Psoriatic Arthritis
health4 months ago

Skin Immune Cells Trigger Hidden Psoriatic Arthritis

Researchers found that immune cells formed in inflamed psoriasis skin can migrate into the bloodstream and travel to joints, where they encounter fibroblasts and ignite inflammation leading to psoriatic arthritis. The study explains why only some psoriasis patients develop arthritis and suggests blood-d detectable migratory cells could serve as an early warning, with future therapies aiming to intercept these cells before joint damage occurs.

via SciTechDaily|
#fibroblasts#health#immune-cells
Wealthy Regions See Rise in Unwanted Disease
health6 months ago

Wealthy Regions See Rise in Unwanted Disease

A global increase in psoriasis, a chronic inflammatory skin condition, is notably higher in wealthier regions like North America and Western Europe, with cases rising over 86% since 1990. Factors such as better diagnosis, hygiene practices, and immune system responses are believed to contribute, although no cure exists, and management involves topical treatments and light therapy.

via AOL.com|
#autoimmune#health#hygiene-hypothesis
Scientists Explore Pollution's Impact on Psoriasis
health8 months ago

Scientists Explore Pollution's Impact on Psoriasis

Recent studies reveal a significant link between air pollution and the triggering or worsening of psoriasis, an autoimmune skin condition, with pollutants like PM2.5 and PAHs contributing to inflammation and immune activation. Individuals in polluted environments, such as those near sugarcane burning or factories, are at increased risk, highlighting the need for regulatory action and personal protective measures.

via Live Science|
#air-quality#autoimmune#environmental-health
Belly Fat and Psoriasis: Uncovering the Hidden Connection
health1 year ago

Belly Fat and Psoriasis: Uncovering the Hidden Connection

Researchers have found a strong link between central abdominal fat and psoriasis, a chronic inflammatory skin condition, suggesting that body fat distribution plays a crucial role in disease risk and severity. The study highlights the potential of using obesity-related treatments, like GLP-1 receptor agonists, to manage psoriasis, emphasizing the importance of targeted weight management and new therapeutic approaches. The findings underscore the need for clinical trials to explore these drugs as potential psoriasis treatments, especially given the rising obesity rates.

via dailymail.co.uk|
#abdominal-fat#glp-1-drugs#health
"Breakthrough Gene Discovery Offers Hope for Psoriasis Patients"
health2 years ago

"Breakthrough Gene Discovery Offers Hope for Psoriasis Patients"

Researchers at The Australian National University have discovered a gene mutation, IKBKB, responsible for causing psoriasis and potentially leading to psoriatic arthritis. The mutation affects the function of immune cells, contributing to inflammation and disease onset. The findings offer hope for improved diagnosis and treatment, potentially leading to a cure for the conditions, which affect hundreds of thousands of Australians. Patients hope to break the stigma associated with these conditions and raise awareness of the challenges they face.

via Medical Xpress|
#autoimmune-disease#gene-discovery#health
"Beyoncé's Impact: From Health Advocacy to Cosmetology Support"
entertainment2 years ago

"Beyoncé's Impact: From Health Advocacy to Cosmetology Support"

Beyonce opened up about her lifelong battle with psoriasis, a chronic autoimmune condition, while promoting her hair care range in an interview with Essence. She shared personal memories of her hair and discussed the importance of salons and barbershops as community spaces. Psoriasis causes rapid skin cell multiplication, leading to scaly patches on the scalp, elbows, or knees.

via Geo News|
#autoimmune-condition#beyonce#entertainment