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Psoriasis

All articles tagged with #psoriasis

Psoriasis Flags Increased Heart Risk, Dermatologists Warn
health1 month ago

Psoriasis Flags Increased Heart Risk, Dermatologists Warn

A dermatologist explains that psoriasis is not just a skin condition but an inflammatory disease recognized as a risk-enhancing factor for heart attacks and strokes, especially when severe. The link involves metabolic syndrome and fat-tissue inflammation; not all inflammatory skin conditions carry the same risk. Doctors recommend regular blood pressure checks and lifestyle changes (healthy diet, exercise, avoiding smoking, adequate sleep) to mitigate cardiovascular risk, while skincare basics emphasize gentle, fragrance-free products.

via AOL.com|
#cardiovascular#dermatology#health
Skin Flares May Reveal Hidden Heart Risk, Dermatologist Says
health1 month ago

Skin Flares May Reveal Hidden Heart Risk, Dermatologist Says

A dermatologist explains that skin inflammation—especially in psoriasis—can signal systemic inflammation linked to higher heart-disease risk, with psoriasis now listed in American Heart Association guidelines as a risk-enhancing inflammatory condition. Not all inflammatory skin issues carry this risk, but persistent skin changes should prompt medical review for potential links to metabolic syndrome and cardiovascular health.

via TODAY.com|
#aha-guidelines#health#heart-health
Takeda's TYK2 rival tops Sotyktu in psoriasis trial, eyeing 2027 launch
business2 months ago

Takeda's TYK2 rival tops Sotyktu in psoriasis trial, eyeing 2027 launch

Takeda's TYK2 inhibitor zasocitinib beat Bristol Myers Squibb's Sotyktu in a Phase 3 head-to-head for moderate-to-severe plaque psoriasis, delivering PASI 100 in over 35% of patients at Week 16 and outperforming on key secondary endpoints with a favorable safety profile; Takeda plans a first-half 2027 launch, signaling continued pressure on Sotyktu as its sales have underperformed since its 2022 approval.

via Fierce Biotech|
#business#psoriasis#sotyktu
Oruka's ORKA-001 Sparks Hopes for a Category-Winning Psoriasis Drug
business4 months ago

Oruka's ORKA-001 Sparks Hopes for a Category-Winning Psoriasis Drug

Oruka Therapeutics reports phase 2a results for ORKA-001, a long-acting IL-23 inhibitor for plaque psoriasis, showing 63.5% of treated patients achieving complete skin clearance (40/63) at week 16 versus 1/21 on placebo, with a clean safety profile and potential for annual dosing. Jefferies analysts say the data could outperform Skyrizi and support $5–$10 billion in sales, helping the stock rise about 30% as the company moves to phase 3 with an active comparator.

via Fierce Biotech|
#business#il-23-inhibitor#orka-001
Keratin 16 acts as a brake on skin inflammation, hinting at new psoriasis therapies
health4 months ago

Keratin 16 acts as a brake on skin inflammation, hinting at new psoriasis therapies

A new study finds keratin 16 normally suppresses skin inflammation by dampening type I interferon signaling; when KRT16 is mutated or absent, inflammation spikes, linking keratin 16 to conditions like pachyonychia congenita, psoriasis, and eczema. The researchers suggest targeting interferon signaling could yield new treatments, as an interferon inhibitor reduced skin lesions in a mouse PC model.

via Live Science|
#health#immune-system#inflammation
From Shame to Clear Skin: A Psoriasis Patient’s Breakthrough Trial
health5 months ago

From Shame to Clear Skin: A Psoriasis Patient’s Breakthrough Trial

A 47-year-old woman, Amber Dean, suffered years of physical and emotional torment from plaque psoriasis, enduring misdiagnoses and failed treatments until she joined a clinical trial for ICOTYDE, the first oral medication for the condition. She now reports full skin clearance and a renewed sense of self, calling the decision one of her best health choices and urging others not to be defined by the disease.

via Yahoo News Canada|
#amber-dean#clinical-trial#health
J&J’s new psoriasis pill could reshape the treatment landscape
healthcare5 months ago

J&J’s new psoriasis pill could reshape the treatment landscape

Johnson & Johnson won U.S. approval for Icotyde, a daily oral medication for moderate-to-severe plaque psoriasis in patients 12 and older, designed to mimic the effects of top-selling injectables like Skyrizi and Tremfya without injections. The pill could expand the patient market and is projected to reach more than $5 billion in peak annual sales, potentially reshaping competition in a multibillion-dollar field.

via statnews.com|
#fda-approval#healthcare#icotyde
Skin Immune Cells Trigger Hidden Psoriatic Arthritis
health7 months ago

Skin Immune Cells Trigger Hidden Psoriatic Arthritis

Researchers found that immune cells formed in inflamed psoriasis skin can migrate into the bloodstream and travel to joints, where they encounter fibroblasts and ignite inflammation leading to psoriatic arthritis. The study explains why only some psoriasis patients develop arthritis and suggests blood-d detectable migratory cells could serve as an early warning, with future therapies aiming to intercept these cells before joint damage occurs.

via SciTechDaily|
#fibroblasts#health#immune-cells
Wealthy Regions See Rise in Unwanted Disease
health9 months ago

Wealthy Regions See Rise in Unwanted Disease

A global increase in psoriasis, a chronic inflammatory skin condition, is notably higher in wealthier regions like North America and Western Europe, with cases rising over 86% since 1990. Factors such as better diagnosis, hygiene practices, and immune system responses are believed to contribute, although no cure exists, and management involves topical treatments and light therapy.

via AOL.com|
#autoimmune#health#hygiene-hypothesis
Scientists Explore Pollution's Impact on Psoriasis
health11 months ago

Scientists Explore Pollution's Impact on Psoriasis

Recent studies reveal a significant link between air pollution and the triggering or worsening of psoriasis, an autoimmune skin condition, with pollutants like PM2.5 and PAHs contributing to inflammation and immune activation. Individuals in polluted environments, such as those near sugarcane burning or factories, are at increased risk, highlighting the need for regulatory action and personal protective measures.

via Live Science|
#air-quality#autoimmune#environmental-health