All articles tagged with #rna splicing
A new study identifies hundreds of previously unknown neuronal microexons and uses machine learning to define the regulatory code governing their splicing. This approach reveals rare genetic variants that disrupt microexon regulation, linking them to autism spectrum disorder in individuals without known genetic causes.
Researchers have mapped the molecular steps of spliceosome termination in human cells using cryo-electron microscopy. The study identifies two distinct intermediate states, the ILSAQR and the DIS, which facilitate the extraction, debranching, and ejection of introns. This process ensures the recycling of spliceosome components and the degradation of intronic RNA, maintaining cellular RNA homeostasis.
New research reveals that alcohol-related liver disease prevents organ repair by trapping cells in an abnormal intermediate state. Inflammation from alcohol processing suppresses the ESRP2 protein, causing widespread RNA splicing errors that mislocate critical proteins. This disrupts the liver's ability to regenerate, even after drinking stops, offering new targets for diagnosis and treatment.
An international study shows boosting NAD+ levels can protect and reverse Alzheimer's-related brain damage by activating an EVA1C-regulated RNA-splicing pathway, correcting mis-splicing, improving hundreds of genes tied to brain health, and restoring memory in worm and mouse models with supporting human brain data—hinting at a new therapeutic approach beyond targeting plaques or tangles.
A study published in Science Advances reveals that boosting NAD⁺ levels can restore memory and improve brain function in Alzheimer's disease models by correcting RNA splicing errors through the regulation of EVA1C, offering potential new therapeutic avenues.
Excessive alcohol impairs liver healing by causing RNA missplicing and reducing ESRP2 protein, trapping liver cells in a non-functional state even after quitting alcohol, which contributes to liver failure. The study suggests potential treatment targets to improve liver recovery.
Long-term alcohol consumption impairs liver regeneration by causing inflammation-induced RNA splicing errors, leading to cells being stuck in an intermediate state; targeting inflammation and restoring ESRP2 may offer new treatment options.
A new study reveals that chronic alcohol use impairs liver regeneration by causing RNA missplicing due to ESRP2 deficiency, leading to cells being trapped in a non-functional state, which contributes to liver failure. The findings suggest potential treatment pathways targeting inflammation and RNA splicing to improve liver recovery.
Research reveals that the protein ELAV acts as a master regulator of circular RNA (circRNA) production in neurons by promoting back-splicing over linear splicing, which contributes to the stability and abundance of circRNAs in the brain, potentially impacting brain health and neurodegenerative diseases.
Scientists have gained new insights into the structural organization and catalytic mechanisms of group II introns, which are RNA molecules involved in splicing. Using cryo-electron microscopy, researchers visualized the intron ribonucleoprotein (RNP) complex at different stages of splicing. They discovered the intricate molecular interactions that position the branch helix and recognize the branchpoint nucleotide. The study also revealed the conformational dynamics of the intron RNP during the splicing process. These findings provide a better understanding of the fundamental reactions involved in RNA splicing and shed light on the evolution of splicing machines.