Tag

Spatial Omics

All articles tagged with #spatial omics

science2 days ago•74 min saved

Spatial-ATAC-Hi-C maps tissue-wide 3D genome and chromatin accessibility

A new microfluidic Spatial-ATAC-Hi-C platform enables simultaneous, genome-wide mapping of 3D genome architecture and chromatin accessibility directly in tissue sections, preserving spatial context. Applied to mouse and human brains and glioma samples, it reveals cell-type–specific 3D genome features and chromatin loops, detects spatial copy-number variations and structural variants, and uncovers clonal heterogeneity across tumor regions, offering a powerful tool for studying spatial gene regulation in health and disease.

via Nature|

#3d-genome #chromatin-accessibility #science

science1 month ago•11 min saved

A Decade of Spatial Transcriptomics Reshapes Tissue Biology

A News & Views piece reflecting on a decade of spatial transcriptomics, tracing how profiling gene expression with preserved tissue context began with the 2016 Science work by Ståhl and has evolved through academia–industry collaboration to map where genes are active in development and disease, reshaping our understanding of tissue biology.

via Nature|

#gene-expression #science #spatial-omics

science2 months ago•4 min saved

3D lamprey brain atlas maps ancient vertebrate brain evolution

Chinese researchers have built the first 3D spatial single-cell atlas of the lamprey brain, enabling reconstruction of ancestral vertebrate brain features and revealing conserved gene expression and neurogenesis patterns with mammals; published as a Science cover article on June 19, 2026, the work suggests early vertebrate brains were already well-partitioned and provides a new resource for brain-evolution studies.

via Global Times|

#brain-atlas #lamprey #science

science6 months ago•66 min saved

Single-cell proteomics maps human liver zonation and its fragility in diseased tissue

Researchers used advanced scDVP to profile hundreds of hepatocytes from 18 people, building a high-resolution map of protein gradients along the liver's porto–central axis. They quantified ~2,500 proteins per cell, showed roughly half are zonated, and introduced gradient-based analysis to quantify zonation without binning. Cross-species comparison with mice revealed shared and human-specific zonation features; in tissues with disrupted architecture, zonation is broadly lost. The study delivers an open-access liver proteome resource and a framework applicable to spatial proteomics.

via Nature|

#liver #proteomics #science

neuroscience2 years ago•4 min saved

Unveiling the Intricate 3D Molecular Mapping of the Brain

Researchers have utilized advanced mass spectrometry imaging and single-cell metabolomics to create 3D molecular maps of the brain, shedding light on its intricate biochemistry and potential implications for treating neurological diseases. This groundbreaking work underscores the importance of interdisciplinary collaboration and offers new insights into the brain's function at different scales, aiming to better understand neurochemical imbalances associated with conditions like depression and Alzheimer’s.

via Neuroscience News|

#brain #deep-learning #molecular-maps