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Stem Cell Therapy

All articles tagged with #stem cell therapy

UK Teenager Achieves Functional Cure for Thalassemia via Gene Editing
health9 days ago

UK Teenager Achieves Functional Cure for Thalassemia via Gene Editing

A 16-year-old UK patient, Vian, has successfully undergone gene editing to reverse symptoms of thalassemia, eliminating the need for lifelong monthly blood transfusions. The treatment, which involves editing stem cells to produce fetal hemoglobin, is described by clinicians as a 'functional cure.' While Vian has recovered and resumed normal activities, another patient, 14-year-old JoelSamuel, is currently undergoing the same procedure for sickle cell disease, highlighting the therapy’s expanding application in UK children’s hospitals.

via BBC|
#birmingham-childrens-hospital#gene-editing#health
Zurich researchers report stem cell transplants restore motor function in stroke-affected mice
science-and-health28 days ago

Zurich researchers report stem cell transplants restore motor function in stroke-affected mice

University of Zurich scientists found that transplanting human neural stem cells into the brains of mice one week after a stroke induced new neuron growth, repaired blood vessels, and restored movement. The study suggests a potential path for regenerative treatments, though significant hurdles remain before human trials.

via ScienceDaily|
#neuroscience#preclinical-research#regenerative-medicine
Collagen Scaffold Stem Cell Grafts Restore Vision in Rare Eye Disorder
health1 month ago

Collagen Scaffold Stem Cell Grafts Restore Vision in Rare Eye Disorder

A new stem cell treatment for aniridia-related keratopathy, a rare eye disorder, has shown significant vision improvements in a small trial. Published in JAMA Ophthalmology, the study utilized a collagen scaffold graft containing both limbal epithelial stem cells and stromal keratocytes. This dual-cell approach, termed RAFT-OS, addresses the failure of traditional transplants by providing the necessary structural and chemical support for cell survival. After an initial complication, the refined procedure resulted in normalized corneal surfaces for five of nine patients by month three. By month twelve, treated eyes showed dramatic health improvements compared to untreated controls, with participants gaining nearly five lines on standard eye charts. The technique suggests that transplanting cells alongside their local support system is crucial for regenerative success, offering hope for other severe eye conditions.

via Medscape|
#aniridia#clinical-trials#health
Chinese Trial Shows Stem Cell Therapy Reverses Heart Failure in 90% of Patients
science1 month ago

Chinese Trial Shows Stem Cell Therapy Reverses Heart Failure in 90% of Patients

A landmark clinical trial in China found that stem cell therapy reversed severe heart failure in 90% of patients. Researchers at Nanjing Drum Tower Hospital injected induced pluripotent stem cells (iPSCs) into the hearts of 10 patients, resulting in significant functional improvements compared to a control group undergoing bypass surgery.

via Yahoo News Canada|
#cardiac-regeneration#heart-failure#ipscs
AI uncovers the data behind Novo's Parkinson's stem-cell program
biotech3 months ago

AI uncovers the data behind Novo's Parkinson's stem-cell program

After Novo Nordisk shuttered its cell-therapy unit, Cellular Intelligence hired neurologist Nuno Mendonça to perform due diligence on Novo’s Parkinson’s stem-cell program. The data trail—drawn from Lund University research and Nature Medicine–published work on dopamine-neuron therapies—appears to have driven the AI-driven assessment that led the firm to pursue Novo’s asset.

via Endpoints News|
#biotech#bluerock-therapeutics#cellular-intelligence
AI Turns Stem Cells Into Predictive, Scalable Therapies
science4 months ago

AI Turns Stem Cells Into Predictive, Scalable Therapies

AI-native platforms are transforming stem-cell research into predictive engineering, accelerating the design, testing, and manufacturing of living cell therapies. Cellular Intelligence is applying an AI foundation model to Novo Nordisk’s clinical-stage Parkinson’s program to speed development, reduce costs, and produce scalable, personalized treatments, with potential applications to cancer and other diseases.

via The Jerusalem Post|
#artificial-intelligence#biotech#parkinsons-disease
Desperate Families Chase Unproven Stem Cell Infusions for Autism as US Oversight Loosens
health4 months ago

Desperate Families Chase Unproven Stem Cell Infusions for Autism as US Oversight Loosens

A Guardian investigation shows a booming US market for unapproved stem cell infusions marketed to autistic children, with families paying tens of thousands despite scant evidence of effectiveness and notable safety concerns. The piece links this growth to political moves by RFK Jr and allies to loosen FDA oversight, describes state efforts like Florida’s permissive stance, and contrasts hopeful anecdotes with controlled trials (Duke and Sutter Health) that found little to no autism improvement, highlighting the risk of exploitation for vulnerable families while regulators grapple with how to respond.

via The Guardian|
#autism#fda-regulation#health
Unproven stem cell infusions for autism draw FDA warnings and political support
health4 months ago

Unproven stem cell infusions for autism draw FDA warnings and political support

Autistic children as young as 18 months are receiving unapproved umbilical cord stem cell infusions at US clinics, promoted with support from Robert F. Kennedy Jr. and autism advocates, despite no proven benefit and FDA warnings that such treatments are likely illegal outside clinical trials; procedures can cost up to $20,000 per session and may require repeated top-ups, while a Duke University trial found little objective improvement and safety risks persist. The article also discusses Mexico‑based trials and marketing tactics by clinics exploiting regulatory gaps and misinterpretations of the Right‑to‑Try law.

via The Guardian|
#autism#fda-warning#health
European Rehab Sparks Optimism for Luka Doncic's Playoff Return
sports6 months ago

European Rehab Sparks Optimism for Luka Doncic's Playoff Return

The Lakers received an optimistic update on Luka Doncic's left hamstring rehab in Europe: after completing the first round of therapies in Spain and a brief stop in Ljubljana, he’ll move to Madrid for a second round, with stem cell/PRP treatment potentially shrinking the standard 4–6 week recovery to about 2–3 weeks and aiming for a playoff return around the start of the second round, while Los Angeles must navigate the first round without him (and without Austin Reaves).

via Sports Illustrated|
#hamstring#lakers#luka-doncic
First-in-utero stem cell treatment appears safe and may enhance spina bifida repair
science7 months ago

First-in-utero stem cell treatment appears safe and may enhance spina bifida repair

In six pregnancies with fetal spina bifida, researchers applied donor placental stem cells during prenatal spinal repair. The phase I CuRe trial found no stem-cell-related adverse events or infections, and newborns showed signs the surgery worked (hindbrain herniation reversal) with no hydrocephalus shunts at birth; long-term benefits remain unknown, and a larger Phase I/IIa trial is underway.

via Gizmodo|
#in-utero#placental-stem-cells#prenatal-surgery
In‑utero stem cell therapy boosts spina bifida outcomes
health7 months ago

In‑utero stem cell therapy boosts spina bifida outcomes

A small US trial treated six fetuses with open spina bifida using placenta-derived mesenchymal stem cells during in‑utero repair. The procedure appeared safe, reversed hindbrain herniation in all cases, and was associated with improved mobility and quality of life after birth, with no tumours or wound-healing issues observed. If reproduced, this approach could become part of standard fetal surgery for spina bifida, marking a potential major step forward in birth defect treatment.

via The Guardian|
#fetal-surgery#health#myelomeningocele
Engineered Stem Cells Target Dopamine Rebuilding in Parkinson's Trial
health8 months ago

Engineered Stem Cells Target Dopamine Rebuilding in Parkinson's Trial

Keck Medicine of USC leads an early-stage trial testing induced pluripotent stem cells engineered to become dopamine-producing brain cells, implanted into the basal ganglia to restore dopamine and motor function in Parkinson’s disease; the 12-participant, multi-site study monitors safety and efficacy for 12–15 months after surgery, with up to five years of follow-up.

via SciTechDaily|
#clinical-trial#dopamine#health