Tag

Parkinsons Disease

All articles tagged with #parkinsons disease

environment1 day ago•4 min saved

Vermont Bans Paraquat Over Parkinson’s Risk, First State Action in the U.S.

Vermont becomes the first U.S. state to ban the herbicide paraquat, citing NIH-linked research that exposure raises Parkinson’s disease risk; the law takes effect on November 1 but allows state regulators to issue special permits through December 31, 2030 for use on certain fruit crops. It requires annual reporting of paraquat use and funds a state study on alternatives. While some lawmakers worry about farmers’ competitiveness, supporters say the health risks justify action, and other states are weighing similar bans amid ongoing lawsuits against the chemical.

via The Guardian|

#ban #environment #herbicide

entertainment1 day ago•5 min saved

Julie Andrews Delivers Rare Video Greeting for World Parkinson's Congress

Julie Andrews, 90, recorded a rare video message to kick off the World Parkinson's Congress, expressing support for finding a cure and urging the Parkinson's community to stay hopeful.

via E! News|

#celebrity #entertainment #julie-andrews

health2 days ago•5 min saved

Bringing Mom Home With Parkinson’s: A Caregiver’s Wake-Up Call

A California woman recounts moving her 78-year-old mother with Parkinson’s into their home to avoid a costly assisted-living facility, only to face intense daily caregiving demands, constant interruptions during work, safety risks from stairs and a large dog, and financial strain. After escalating stress, they moved her to a smaller, more communal facility with in-home support and, eventually, hospice, which provided better care and allowed the family to regain balance and quality time together.

via Business Insider|

#caregiving #elder-care #family-dynamics

business6 days ago•2 min saved

Biogen and Denali end LRRK2 Parkinson’s program after phase 2b setback

Biogen and Denali terminated BIIB122 (DNL151), a LRRK2 inhibitor for idiopathic Parkinson’s, after a phase 2b trial failed to meet its primary endpoint despite strong target engagement (about 90% peripheral LRRK2 inhibition and a ~30% CSF biomarker decrease). The decision ends the idiopathic program, though Denali will continue a phase 2a trial in LRRK2-associated Parkinson’s, and the deal’s upfront cost ($400 million in 2020) and earlier phase 3 cutbacks underscore the challenge of translating target activity into clinical benefit in Parkinson’s disease.

via Fierce Biotech|

#biib122-dnl151 #biogen #business

health6 days ago•2 min saved

Parkinson’s LRRK2 drug fails pivotal trial, dimming hopes for broad therapy

Biogen and Denali Therapeutics' experimental Parkinson’s drug targeting the LRRK2 protein did not slow disease progression in a large randomized trial, delivering a setback to the idea that LRRK2 blockade could benefit all patients with Parkinson’s disease.

via statnews.com|

#biogen #clinical-trial #denali-therapeutics

health13 days ago•37 min saved

Reynolds highlights Parkinson’s unseen symptoms and the power of speaking up

Ryan Reynolds opens up about his father’s Parkinson’s diagnosis and the disease’s often overlooked psychotic symptoms—hallucinations and delusions—that affect many patients. He’s championed More to Parkinson’s with Acadia Pharmaceuticals to raise awareness and discuss treatments like pimavanserin (Nuplazid). Neurologists note that 50%+ of people with Parkinson’s may experience such symptoms, underscoring the importance of open dialogue to reduce stigma. The piece also covers caregiver fatigue, practical guidance for families (reassure, acknowledge, redirect), and the NIH-funded Persevere trial to mentor new care partners, while highlighting the broader message that discussing these issues can improve care and outcomes.

via Brain & Life|

#caregiver-fatigue #delusions #hallucinations

health14 days ago•9 min saved

Ryan Reynolds Opens Up About His Father’s Hidden Parkinson’s Hallucinations and Family Struggles

Ryan Reynolds reveals how his father James, diagnosed with Parkinson’s at 52, later developed vivid hallucinations and delusions that doctors initially attributed to other causes, leaving his wife Tammy an overwhelmed caregiver. He details the loneliness and miscommunication around non-motor PD symptoms, the dangers of older antipsychotics for PD patients, and the shift to newer, safer treatments. Reynolds reflects on their strained relationship, the care his family provided, and his advocacy for awareness through the Michael J. Fox Foundation, urging others to openly discuss cognitive symptoms to improve empathy and quality of life for patients and caregivers.

via Prevention|

#caregiving #delusions #hallucinations

health15 days ago•6 min saved

Blocking GPNMB Could Slow Parkinson's Progression

Researchers identify the brain protein GPNMB, largely produced by microglia, as a driver of alpha-synuclein spread in Parkinson's disease. Monoclonal antibodies that block GPNMB halted this spread in neuronal models, and analysis of 1,675 brains linked higher GPNMB levels to more extensive pathology, suggesting a potential disease-modifying therapy—though human trials have not yet begun.

via Neuroscience News|

#alpha-synuclein #gpnmb #health

health25 days ago•9 min saved

Your long-term diet could tilt Parkinson’s risk, doctors say

Observational studies suggest enduring dietary patterns may influence Parkinson’s disease risk, age at onset and possibly symptom severity. Doctors highlight Mediterranean and MIND diets—rich in antioxidants and anti-inflammatory nutrients—as potentially protective and linked to later onset, while flavonoid-rich foods, coffee, fatty fish, fiber and fermented foods may support brain health. Conversely, dairy (especially milk), ultraprocessed foods and certain dietary pesticide exposures are associated with higher risk in some studies. Experts caution these are associations, not proven causes, and diet is one lever among several (exercise, sleep, gut health) in shaping Parkinson’s outcomes.

via Fox News|

#diet #flavonoids #health

local27 days ago•27 min saved

West Valley Parkinson's data review kicks off amid community concerns

Utah health officials have begun an early data review to determine whether there are higher-than-expected Parkinson's disease rates in a West Valley City neighborhood near 3500 South and 4800 West; officials emphasize this is surveillance, not an investigation, and no environmental link has yet been found, with a clearer picture expected in coming weeks.

via KUTV|

#epidemiology #local #parkinsons-disease

health28 days ago•7 min saved

Gut microbes may foretell Parkinson's years before symptoms

Researchers from UCL analyzed gut microbes in more than 1,400 participants across the UK, Korea, and Turkey and found distinct microbiome patterns linked to Parkinson's risk, including in non-symptomatic GBA1 carriers; a diverse diet correlated with lower risk profiles, but the study is observational and cannot prove causation, though it supports the gut-brain axis as a potential avenue for early detection and treatment.

via Fox News|

#early-detection #gba1 #gut-brain-axis

health1 month ago•23 min saved

Gut signals could flag Parkinson's risk years before symptoms

University College London researchers identified a gut microbiome signature linked to Parkinson's disease risk, especially in people with the GBA1 variant, suggesting a stool test could detect the disease well before tremors emerge and that diet and gut health may modulate risk.

via New York Post|

#early-detection #genetics #gut-health

science1 month ago•7 min saved

Gut Microbes Signal Parkinson’s Risk Years Before Symptoms

A multi-cohort study finds a distinctive gut microbiome signature that distinguishes people with Parkinson’s and healthy individuals at genetic risk (including GBA1 carriers without symptoms), suggesting the gut microbiome could serve as an early warning and preventive target. Findings replicated across UK, Korea, and Turkey with over 1,400 participants; diet diversity may influence risk, and UCL-led trials are testing gut-targeted therapies, including using a common cough medicine, to slow progression.

via Neuroscience News|

#early-detection #gba1 #gut-microbiome

health1 month ago•13 min saved

Diet patterns tied to lower Parkinson’s risk and what to avoid

Emerging research links gut health and diet to Parkinson’s risk. The Mediterranean and MIND dietary patterns may lower risk or delay onset, while high dairy and ultra-processed food intake is associated with higher risk; caffeine has been linked to reduced risk, underscoring diet as a potential modulator of Parkinson’s disease.

via The Washington Post|

#gut-health #health #healthy-eating

science1 month ago•33 min saved

Century-old solvent linked to elevated Parkinson's risk

Trichloroethylene (TCE), a century-old solvent once used in dry cleaning and various household products, is linked to a roughly fivefold increase in Parkinson's disease risk, with both occupational and environmental exposure. Researchers from the University of Rochester Medical Center say the long latency between exposure and symptoms can obscure cause, and historical cases like Camp Lejeune highlight community risks. Public health actions include the EPA banning TCE manufacture/import and processing, with risk evaluations and regulations continuing to guide safeguards.

via Yahoo|

#dry-cleaning #environmental-exposure #epa-ban